Abstract：
:White matter (WM) abnormality in somatization disorder (SD) has not been reported yet. This study was designed to elucidate the alterations in WM integrity in SD. A total of 25 patients with SD and 28 healthy controls were enrolled in the study. WM integrity was analyzed using tract-based spatial statistics. No differences were found between the patients and the controls for fractional anisotropy (FA) values, mean diffusivity (MD), axial diffusivity, and radial diffusivity values at the corrected p<0.05 level. Patients with SD had significantly decreased FA values in the cingulum and inferior fronto-occipital fasciculus, and significantly increased MD values in the anterior thalamic radiation and corticospinal tract compared with the controls at the uncorrected p<0.005 level. Somatization severity was correlated with the FA values of the cingulum and inferior fronto-occipital fasciculus in the patients. The patients exhibit suggestive alterations in WM integrity in the cingulum, inferior fronto-occipital fasciculus, anterior thalamic radiation, and corticospinal tract.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Zhang J,Jiang M,Yao D,Dai Y,Long L,Yu M,Liu J,Zhang Z,Xiao C,Guo Wdoi
10.1016/j.neulet.2015.05.037subject
Has Abstractpub_date
2015-07-10 00:00:00pages
102-8eissn
0304-3940issn
1872-7972pii
S0304-3940(15)00394-8journal_volume
599pub_type
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