Abstract:
:The binding of radioiodinated omega-conotoxin GVIA, a probable Ca channel antagonist, to synaptic plasma membranes of rat brain was examined. Two kinds of specific binding sites were found with apparent dissociation constants of 10 pM and 0.5 nM and maximum binding capacities of 0.5 and 3.4 pmol/mg prot., respectively. The binding of the toxin was not affected by high concentrations of Ca antagonists or an agonist, indicating distinct binding sites of the toxin from those of these drugs. Divalent and trivalent metal ions strongly inhibited the binding. The order of their inhibitory potencies was similar to that for inhibition of the Ca current through certain Ca channels. These results suggest that the binding sites of omega-conotoxin GVIA are functionally related to the Ca2+-binding site postulated to be in the pore of the Ca channel.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Abe T,Koyano K,Saisu H,Nishiuchi Y,Sakakibara Sdoi
10.1016/0304-3940(86)90559-8subject
Has Abstractpub_date
1986-11-11 00:00:00pages
203-8issue
2eissn
0304-3940issn
1872-7972pii
0304-3940(86)90559-8journal_volume
71pub_type
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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