Permissive effect of VIP on the hyperglycemic response induced by 2-deoxy-D-glucose.

Abstract:

:We previously obtained evidence that in rats the neurons in the suprachiasmatic nucleus (SCN) receiving retinal neural inputs may be involved in the regulation of glucose metabolism. In this study we examined whether the SCN neurons containing vasoactive intestinal peptide (VIP)-like immunoreactive substance (VIP neurons) are involved in its regulation. We found that the hyperglycemic and hyperglucagonemic responses to intracranial injection of 2-deoxy-D-glucose (2DG) were synergistically enhanced by intracranial administration of VIP, and that these responses were significantly suppressed by treatment with anti-VIP antibody. These results suggest that VIP has a permissive effect on the hyperglycemic and hyperglucagonemic responses to 2DG, and thus that the VIP neurons in the SCN are probably involved in the regulation of glucose metabolism.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Shimizu K,Hibino H,Komenami N,Nagai N,Nagai K,Nakagawa H

doi

10.1016/0304-3940(94)91103-7

subject

Has Abstract

pub_date

1994-07-04 00:00:00

pages

157-60

issue

1-2

eissn

0304-3940

issn

1872-7972

pii

0304-3940(94)91103-7

journal_volume

175

pub_type

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