Abstract:
:Molecular mechanisms regulating positions of oligodendrocyte precursor cells (OPCs) remain unclear in developing cerebral cortex. To explore the mechanisms, we investigated how Plexin-A4, receptor of Semaphorin in OPCs, is involved in the positioning. We found that Plexin-A4 knockout mice exhibited (1) an increased number of OPCs in both the upper- and middle-regions of the cortical plate, where both indirect- and direct-ligands of Plexin-A4, Sema3A and Sema6A, respectively, were continuously expressed, and (2) aberrant distributions of OPCs in both the intermediate zone and corpus callosum, where Plexin-A4 was richly expressed in wild-type mice. These results suggest that Plexin-A4 is involved in the precise positioning of OPCs in developing cerebral cortex.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Okada A,Tomooka Ydoi
10.1016/j.neulet.2012.04.005subject
Has Abstractpub_date
2012-05-16 00:00:00pages
259-64issue
2eissn
0304-3940issn
1872-7972pii
S0304-3940(12)00512-5journal_volume
516pub_type
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