Possible roles of Plexin-A4 in positioning of oligodendrocyte precursor cells in developing cerebral cortex.

Abstract:

:Molecular mechanisms regulating positions of oligodendrocyte precursor cells (OPCs) remain unclear in developing cerebral cortex. To explore the mechanisms, we investigated how Plexin-A4, receptor of Semaphorin in OPCs, is involved in the positioning. We found that Plexin-A4 knockout mice exhibited (1) an increased number of OPCs in both the upper- and middle-regions of the cortical plate, where both indirect- and direct-ligands of Plexin-A4, Sema3A and Sema6A, respectively, were continuously expressed, and (2) aberrant distributions of OPCs in both the intermediate zone and corpus callosum, where Plexin-A4 was richly expressed in wild-type mice. These results suggest that Plexin-A4 is involved in the precise positioning of OPCs in developing cerebral cortex.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Okada A,Tomooka Y

doi

10.1016/j.neulet.2012.04.005

subject

Has Abstract

pub_date

2012-05-16 00:00:00

pages

259-64

issue

2

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(12)00512-5

journal_volume

516

pub_type

杂志文章
  • Endogenous adrenergic control of reflexes evoked by mechanical stimulation of the heel in the decerebrated rabbit.

    abstract::In decerebrated rabbits, reflexes were evoked in medial gastrocnemius motoneurones by mechanical stimulation of the heel, using four pinch strengths from 183 (innocuous) to 4577 (noxious) mN. The alpha(2)-adrenoceptor antagonist idazoxan (1-156 microg intrathecal (i.th.) significantly increased responses to pinch stre...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(01)02005-5

    authors: Clarke RW,Harris J,Houghton AK

    更新日期:2001-08-10 00:00:00

  • Cholinergic agonists increase intracellular Ca2+ in cultured human microglia.

    abstract::Microglia are resident phagocytic cells in the central nervous system (CNS), and can be activated in response to various stimuli including neurotransmitters. Using fura-2 imaging, we investigated the effects of carbachol (CCh), a cholinergic agonist, on [Ca2+]i in cultured human microglia. Treatment of microglia with ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(98)00706-x

    authors: Zhang L,McLarnon JG,Goghari V,Lee YB,Kim SU,Krieger C

    更新日期:1998-10-09 00:00:00

  • Soybean agglutinin binding to the olfactory systems of the rat and mouse.

    abstract::The binding of the lectin soybean agglutinin (SBA) to the olfactory system of both the rat and mouse was investigated histochemically. SBA bound to fibers in the accessory olfactory nerve and to glomeruli in the accessory olfactory bulb. In addition, SBA binding sites were present in some, but not all, glomeruli in th...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(86)90591-4

    authors: Key B,Giorgi PP

    更新日期:1986-08-29 00:00:00

  • Genetic variation in FOXP2 alters grey matter concentrations in schizophrenia patients.

    abstract::FOXP2, the first gene known to be involved in the development of speech and language, can be considered to be, a priori, a candidate gene in schizophrenia, given the mounting evidence that the underlying core deficit in this disease could be a failure of structures relevant to normal language processing. To investigat...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2011.02.024

    authors: Španiel F,Horáček J,Tintěra J,Ibrahim I,Novák T,Čermák J,Klírová M,Höschl C

    更新日期:2011-04-15 00:00:00

  • Frequency tuning of input-output relation in a rat cortical neuron in-vitro.

    abstract::The input-output relation of a single neuron stands at the basis of every biologically oriented description of the brain. This report shows that the input-output relation of cultured cortical neurons is non-linearly tuned by the input frequency. Increasing the rate of stimulation results in the appearance of ordered t...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(01)01534-8

    authors: Tal D,Jacobson E,Lyakhov V,Marom S

    更新日期:2001-03-02 00:00:00

  • Crossed thalamo-cortical and cortico-thalamic projections in adult mice.

    abstract::The crossed thalamo-cortical and cortico-thalamic connections of the mouse are drawn using the tracer wheat germ agglutinin-horseradish peroxidase. After injections in the frontal cortex of the right hemisphere cells labeled retrogradely and axons labeled anterogradely are observed in the thalamus ipsilateral and cont...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(96)12319-3

    authors: Carretta D,Sbriccoli A,Santarelli M,Pinto F,Granato A,Minciacchi D

    更新日期:1996-02-02 00:00:00

  • Changes in electromyographically recorded human monosynaptic reflex in relation to hypnotic susceptibility and hypnosis.

    abstract::The aim of the present experiment was to study how hypnotic susceptibility and hypnosis affect motoneuron excitability. In a first trial, human subjects were selected according to their hypnotic susceptibility. In a second trial, the Hoffmann (H) reflex amplitude of the soleus muscle was studied in 3 groups: (1) highl...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(89)90347-9

    authors: Santarcangelo EL,Busse K,Carli G

    更新日期:1989-09-25 00:00:00

  • Magnetic fields abolish nychthemeral rhythmicity of responses of Purkinje cells to the pineal hormone melatonin in the pigeon's cerebellum.

    abstract::The effects of micro-electrophoretically applied melatonin on the electrical activity of Purkinje cells in the cerebellum of anaesthetized pigeons were studied. The proportion of excitatory and inhibitory responses to the pineal indoleamine varied significantly depending on whether the cells were tested during the day...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(86)90072-8

    authors: Demaine C,Semm P

    更新日期:1986-12-12 00:00:00

  • Fos in locus coeruleus neurons following audiogenic seizure in the genetically epilepsy-prone rat: comparison to electroshock and pentylenetetrazol seizure models.

    abstract::Seizures in genetically epilepsy-prone rats (GEPRs) may result from hypoactivity of locus coeruleus (LC) neurons during seizures. This study examined Fos-like-immunoreactivity (FLI) in the LC following audiogenic seizures in two strains of GEPRs (GEPR-9s and -3s), and following pentylenetetrazol (PTZ) or maximal elect...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(97)00611-3

    authors: Eells JB,Clough RW,Browning RA,Jobe PC

    更新日期:1997-09-12 00:00:00

  • Connections of the mediodorsal nucleus of the thalamus in the tree shrew. II. Efferent connections.

    abstract::[35S]Methionine was injected into the mediodorsal nucleus of the thalamus of 5 adult tree shrews (Tupaia belangeri) and into the medioventral thalamic nucleus in another tree shrew. Three animals survived for 44 h and three others for two weeks (including the animal with the injection in the medioventral nucleus). Con...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(80)90249-9

    authors: Divac I,Passingham RE

    更新日期:1980-08-01 00:00:00

  • Vesicle degradation in dendrites of magnocellular neurones of the rat supraoptic nucleus.

    abstract::The magnocellular neurones of the supraoptic nucleus (SON) and paraventricular nucleus release neuropeptide from their axon terminals and also from their dendrites. In the axon terminals, swellings known as Herring bodies are responsible for the degradation of aged, unreleased large dense-cored vesicles (LDCVs) by lys...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2010.11.060

    authors: Monteiro O,Wiegand UK,Ludwig M

    更新日期:2011-02-01 00:00:00

  • The mechanism of inhibition by xanthine of adenosine A1-receptor responses in rat hippocampus.

    abstract::We have recently observed that the free radical-generating mixture of xanthine and xanthine oxidase (X/XO) can suppress the inhibitory effects of adenosine on synaptic transmission in the hippocampus, but that this action can be mimicked by xanthine alone. We have now clarified the mechanism of these interactions by u...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2004.04.075

    authors: Shahraki A,Fukunari A,Stone TW

    更新日期:2004-07-29 00:00:00

  • Effects of a prepulse stimulus on the masseteric inhibitory reflex in humans.

    abstract::We investigated the effects of a weak cutaneous stimulus applied to the digital nerves (prepulse) on the masseter inhibitory reflex (MIR) to electrical stimulation of the mental nerve in nine healthy volunteers. The prepulse stimulus, which had no direct effect on the masseter muscle EMG activity, induced a significan...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(96)12574-x

    authors: Gómez-Wong E,Valls-Solé J

    更新日期:1996-04-26 00:00:00

  • Barrels in somatosensory cortex of normal and reeler mutant mice.

    abstract::The pattern of projection of the ventrobasal thalamic complex (VB) upon the neocortical barrel field of normal and reeler mutant mice was determined by orthograde degeneration experiments and by Timm's histochemical method. In both reeler and normal mice the thalamic terminals are concentrated at the midcortical zone ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(76)90091-4

    authors: Caviness VS Jr,Frost DO,Hayes NL

    更新日期:1976-09-01 00:00:00

  • Inter-limb transfer of kinematic adaptation in individuals with motor difficulties.

    abstract::A previous study suggested that adults with greater motor difficulties demonstrated less adaptation under a regular error feedback schedule (gain=1:1) but reached a similar level of adaptation compared to controls when feedback was enhanced (gain=1:2). In light of these findings, the present study examined inter-limb ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2017.06.030

    authors: Bo J,Lee CM

    更新日期:2017-07-27 00:00:00

  • Region-specific phosphorylation of ATF-2, Elk-1 and c-Jun in rat hippocampus and cerebellum after electroconvulsive shock.

    abstract::There have been reports of regional differences in the activation of mitogen activated protein kinases (MAPKs) and in the induction of immediate early genes after electroconvulsive shock (ECS) in the rat brain. This study was performed to determine whether ECS induce the region-specific phosphorylation of MAPK-downstr...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(02)00568-2

    authors: Ahn YM,Kang UG,Oh SW,Juhnn YS,Joo YH,Park JB,Kim YS

    更新日期:2002-08-23 00:00:00

  • Increased density of galanin binding sites in the dorsal raphe in a genetic rat model of depression.

    abstract::The Flinders Sensitive Line rats showed an increased immobility response by 104% (P<0.01) in the forced swim test with respect to the Flinders Resistant Line rats (control). The Flinders Sensitive Line rats also had an increase of [(125)I]galanin (porcine) binding in the dorsal raphe (55+/-3.3 fmol/mg protein) with re...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(01)02446-6

    authors: Bellido I,Díaz-Cabiale Z,Jiménez-Vasquez PA,Andbjer B,Mathé AA,Fuxe K

    更新日期:2002-01-11 00:00:00

  • Influence of a deletion of protein kinase C gamma isoform in the G-protein activation mediated through opioid receptor-like-1 and mu-opioid receptors in the mouse pons/medulla.

    abstract::The aim of the present study was to investigate whether mice with a deletion of the gene that encodes the protein kinase C gamma (PKC gamma) isoform could affect the G-protein activation mediated through the opioid receptor-like (ORL-1) receptor and mu-opioid receptor in the mouse pons/medulla and spinal cord, monitor...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(02)00753-x

    authors: Narita M,Mizoguchi H,Khotib J,Suzuki M,Ozaki S,Yajima Y,Narita M,Tseng LF,Suzuki T

    更新日期:2002-10-04 00:00:00

  • Expression of the exon 1A-containing PMP22 transcript is altered in the trembler mouse.

    abstract::The trembler mouse suffers from a dominantly inherited mutation of the peripheral myelin protein 22 (PMP22) gene which results in an abnormal myelination of its peripheral nervous system. The recent identification of two different PMP22 mRNA differing in their 5' non-translated region led us to monitor their respectiv...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(95)12008-r

    authors: Garbay B,Boiron-Sargueil F,Cassagne C

    更新日期:1995-10-06 00:00:00

  • Time course of recovery of the somatosensory map following hindpaw sensory deprivation in the rat.

    abstract::Hindlimb sensory deprivation is known to induce a decrease in the cortical representation of hindpaw, and an increase in the size of the cutaneous receptive fields. The aim of the present study was to determine (i) the time-course of recovery when the rat retrieves a normal use of its limbs after a 14-day period of se...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(01)02050-x

    authors: Dupont E,Canu MH,Langlet C,Falempin M

    更新日期:2001-08-24 00:00:00

  • Functional modulation of gamma-aminobutyric acid(A) receptors by etifoxine and allopregnanolone in rodents.

    abstract::We looked for an interaction between etifoxine and the neurosteroid allopregnanolone at central gamma-aminobutyric acid (GABA(A)) receptors. Etifoxine (2 microM) did not affect the affinity of allopregnanolone (IC(50)=108 nM) for its site in preparations of Sprague-Dawley rat cerebral cortex membranes, as determined b...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(01)01647-0

    authors: Verleye M,Schlichter R,Neliat G,Pansart Y,Gillardin JM

    更新日期:2001-04-06 00:00:00

  • Childhood trauma and emotion regulation: The moderator role of BDNF Val66Met.

    abstract::Emotion regulation difficulties have been involved in multiple forms of psychopathology and may represent an important focus for current efforts to understand the biological mechanisms underlying transdiagnostic symptoms. The present study investigated a gene-environment interaction (G × E) in reappraisal, a form of e...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2018.07.018

    authors: Bîlc MI,Vulturar R,Chiș A,Buciuman M,Nuţu D,Bunea I,Szentágotai-Tătar A,Miu AC

    更新日期:2018-10-15 00:00:00

  • Glucagon-induced somatostatin release from perifused rat hypothalamus: calcium dependency and effect of cysteamine treatment.

    abstract::Somatostatin (SRIF) release from rat hypothalamus was investigated in vitro with a perifusion system. Glucagon (1 microM) and high potassium concentrations (56 mM) stimulated SRIF release in a calcium-dependent manner. Pretreatment of the rat with cysteamine (30 mg/100 g body weight, 7 h earlier) significantly reduced...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(83)90445-7

    authors: Shimatsu A,Kato Y,Matsushita N,Ohta H,Kabayama Y,Imura H

    更新日期:1983-06-30 00:00:00

  • High test-retest-reliability of pain-related evoked potentials (PREP) in healthy subjects.

    abstract::Pain-related evoked potentials (PREP) is an established electrophysiological method to evaluate the signal transmission of electrically stimulated A-delta fibres. Although prerequisite for its clinical use, test-retest-reliability and side-to-side differences of bilateral stimulation in healthy subjects have not been ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2017.03.037

    authors: Özgül ÖS,Maier C,Enax-Krumova EK,Vollert J,Fischer M,Tegenthoff M,Höffken O

    更新日期:2017-04-24 00:00:00

  • [125I]dynorphin(1-8) produces a similar pattern of kappa-opioid receptor labelling to [3H]dynorphin(1-8) and [3H]etorphine in guinea pig brain: a quantitative autoradiographic study.

    abstract::kappa-Opioid receptors were radiolabelled with the peptides [125I]dynorphin(1-8) and [3H]dynorphin(1-8) or with [3H]etorphine on guinea pig forebrain and cerebellar sections and visualized by quantitative autoradiography. All three radioligands yielded similar patterns of kappa-receptor localization. However, quantita...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(88)90495-8

    authors: Sharif NA,Hunter JC,Hill RG,Hughes J

    更新日期:1988-04-12 00:00:00

  • Dilation of the inferior colliculus and hypersensitivity to sound in Wnt1-cre and Wnt1-GAL4 double-transgenic mice.

    abstract::The processing of sound information is mediated by the cochlea and the central auditory system. Among the central auditory system, the inferior colliculus (IC) has leading roles in the acoustic processing. In a previous study, we demonstrated psychiatric disorder-related behavioral abnormalities in a genetically modif...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2014.02.061

    authors: Nakajima M,Nishikawa C,Miyasaka Y,Kikkawa Y,Mori H,Tsuruta M,Okuyama S,Furukawa Y

    更新日期:2014-04-30 00:00:00

  • Intracerebroventricular administration of corticotropin-releasing factor antagonist attenuates arousal response accompanied by yawning behavior in rats.

    abstract::We have reported that an arousal response accompanied by yawning behavior can be evoked by electrical and chemical stimulation of the hypothalamic paraventricular nucleus (PVN) in rats, although the mechanism responsible for the arousal response accompanied by yawning evoked by PVN stimulation is still unknown. In the...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2008.01.006

    authors: Kita I,Kubota N,Yanagita S,Motoki C

    更新日期:2008-03-15 00:00:00

  • Potentiation of N-methyl-D-aspartate receptor-dependent afterdischarges in rat dentate gyrus following in vitro ethanol withdrawal.

    abstract::The contribution of NMDA receptors to neuronal hyperexcitability following in vitro ethanol withdrawal was examined using afterdischarges (ADs) in rat dentate gyrus as a model system. ADs were evoked by high frequency stimuli and blocked by N-methyl-D-aspartate (NMDA) receptor antagonists. Ethanol (75 mM) inhibited AD...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(94)91055-3

    authors: Morrisett RA

    更新日期:1994-02-14 00:00:00

  • Cognitive alteration after carotid revascularization is correlated with cortical GABA(B)-ergic modulations.

    abstract::The present study evaluates the hypotheses that a GABAergic mechanism underlies neurobehavioral sequelae of carotid stenosis and that it can be reversed by carotid revascularization. We used the Rivermead Behavioural Memory Test (RBMT), short interval intracortical inhibition (SICI), intracortical facilitation (ICF), ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2011.04.052

    authors: Murata K,Fujiki M,Ooba H,Kubo T,Morishige M,Abe T,Ishii K,Kobayashi H,Kiyosue H,Mori H

    更新日期:2011-08-18 00:00:00

  • NMDAR blockade-induced neonatal brain injury: Reversal by the calcium channel agonist BayK 8644.

    abstract::We have previously shown that P7 rat pups injected with the N-methyl-d-aspartate receptor (NMDAR) blocker MK801 displayed robust apoptotic injury within hours after injection. Further studies from our lab suggest that loss of calcium cannot be compensated for when vulnerable neurons lack calcium buffering capabilities...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2008.12.002

    authors: Turner CP,Debenedetto D,Liu C

    更新日期:2009-02-06 00:00:00