Abstract:
:Somatostatin (SRIF) release from rat hypothalamus was investigated in vitro with a perifusion system. Glucagon (1 microM) and high potassium concentrations (56 mM) stimulated SRIF release in a calcium-dependent manner. Pretreatment of the rat with cysteamine (30 mg/100 g body weight, 7 h earlier) significantly reduced SRIF release from the hypothalamus in glucagon- and high potassium-stimulated states as well as in the basal state. SRIF release from rat hypothalamus was also stimulated by both dibutyryl cyclic AMP (1 mM) and theophylline (3 mM). These results suggest that glucagon, acting in a calcium-dependent manner and possibly through the adenylate cyclase-cyclic AMP system, stimulates SRIF release from rat hypothalamus and that cysteamine treatment reduces releasable SRIF in the hypothalamus.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Shimatsu A,Kato Y,Matsushita N,Ohta H,Kabayama Y,Imura Hdoi
10.1016/0304-3940(83)90445-7subject
Has Abstractpub_date
1983-06-30 00:00:00pages
285-9issue
3eissn
0304-3940issn
1872-7972pii
0304-3940(83)90445-7journal_volume
37pub_type
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