Abstract:
:In the present study, we examined the localizations of canonical transient receptor potential channels (TRPCs) in rat basal ganglia. The dot-like staining pattern of TRPC5 was observed through the globus pallidus (GP) and caudate-putamen. TRPC7 had a strikingly high level of expression in the neuropil in the GP. In the subthalamic nucleus, strong staining for TRPC5 was observed in the cell bodies, while moderate to high immunoreactivies for TRPC1, TRPC3, TRPC4 and TRPC7 were found in the cell bodies and surrounding neuropil. In the substantia nigra, immunoreactivities for TRPC3 and TRPC7 were prominent in the cell bodies and several processes in the pars compacta and pars reticulata. TRPC6 was expressed in the neuropil, not in the cell bodies. This study may provide useful data for the future investigations on the structural and functional properties of TRPCs.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Chung YH,Kim D,Moon NJ,Oh CS,Lee E,Shin DH,Kim SS,Lee WB,Lee JY,Cha CIdoi
10.1016/j.neulet.2007.05.042subject
Has Abstractpub_date
2007-07-05 00:00:00pages
18-23issue
1eissn
0304-3940issn
1872-7972pii
S0304-3940(07)00572-1journal_volume
422pub_type
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