Abstract：
:Cholecystokinin (CCK) is suggested to be involved, e.g. in the central nervous modulation of food intake, possibly by acting within specific hypothalamic nuclei. Perinatal overnutrition predisposes to permanent obesity and hyperphagia, while underlying mechanisms are unclear. By reducing the litter size from the 3rd to 21st day of life, early overnutrition was induced in newborn rats. At weaning, clear overweight (P < 0.001), hyperglycaemia (P < 0.05), hyperinsulinaemia (P < 0.001), and insulin resistance (P < 0.001) occured. These early signs of obesity were associated with a significantly decreased number of CCK-positive neurons in the paraventricular hypothalamic nucleus (P < 0.002). In conclusion, due to neonatal overfeeding malformation of CCKergic neurons at the end of the critical hypothalamic differentiation period occurs. Long-term consequences on CCK-related neuroendocrine regulations could be suggested, including those affecting food intake and body weight gain.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Plagemann A,Rake A,Harder T,Melchior K,Rohde W,Dörner Gdoi
10.1016/s0304-3940(98)00823-4subject
Has Abstractpub_date
1998-12-11 00:00:00pages
13-6issue
1eissn
0304-3940issn
1872-7972pii
S0304-3940(98)00823-4journal_volume
258pub_type
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