The role of nitric oxide in the proconvulsant effect of delta-opioid agonist SNC80 in mice.

Abstract:

:The involvement of nitric oxide (NO) in modulation of seizure susceptibility by delta-opioid agonist (+)-4-((alpha R)-alpha-((2S, 5R)-4-allyl-2, 5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-N, N-diethyl-benzamide (SNC80) was examined in mice. Systemic administration of SNC80 (0.1-5 mg/kg, intraperitoneally (i.p.)) decreased the threshold for clonic seizures induced by pentylenetetrazole. The non-specific NO synthase (NOS) inhibitor, N(G)-nitro-L-arginine methyl ester (3-20 mg/kg, i.p.), but not the specific inducible NOS inhibitor, aminoguanidine (50 and 100 mg/kg, i.p.) inhibited the proconvulsant effect of SNC80. On the other hand, NO substrate, L-arginine (30 and 60 mg/kg, i.p.) potentiated the proconvulsant effect of a lower dose of SNC80 (0.5 mg/kg). These results support the involvement of NO, produced by constitutive NOS, in the proconvulsant effect of the delta-opioid agonist.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Khavandgar S,Homayoun H,Dehpour AR

doi

10.1016/s0304-3940(02)00417-2

keywords:

subject

Has Abstract

pub_date

2002-08-30 00:00:00

pages

237-9

issue

2

eissn

0304-3940

issn

1872-7972

pii

S0304394002004172

journal_volume

329

pub_type

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