当前位置： SCI文献检索 > NEUROSCIENCE LETTERS期刊下所有文献 > Intracerebroventricular injection of losartan inhibits angiotensin II-sensitive neurons via GABA inputs in the anterior hypothalamic area of rats.

Intracerebroventricular injection of losartan inhibits angiotensin II-sensitive neurons via GABA inputs in the anterior hypothalamic area of rats.

Abstract：

:Previously, we have demonstrated that pressure-ejected application of angiotensin II and losartan, an angiotensin AT1 receptor antagonist, onto some neurons in the anterior hypothalamic area (AHA) of the rat increases and decreases, respectively, the basal firing rate of the neurons. To investigate possible participation of these AHA neurons in the brain angiotensin system, we examined whether intracerebroventricular injection of the angiotensin AT1 receptor antagonist losartan inhibits the neuronal activity of angiotensin II-sensitive neurons via GABA inputs in the AHA of rats. Intracerebroventricular injection of losartan decreased the firing rate of AHA angiotensin II-sensitive neurons. However, the intracerebroventricular injection of losartan did not affect the increase in firing rate of AHA angiotensin II-sensitive neurons induced by pressure application of angiotensin II onto the same neurons, although losartan similarly injected abolished the increase in firing rate of AHA angiotensin II-sensitive neurons induced by intracerebroventricular injection of angiotensin II. The losartan-induced decrease of unit firing in AHA neurons was abolished by pressure application of the GABAA receptor antagonist bicuculline onto the same neurons. Bicuculline itself did not affect the basal firing rate of AHA neurons. These findings suggest that intracerebroventricular injection of losartan inhibits AHA angiotensin II-sensitive neurons via GABA inputs to the neurons.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Hagiwara Y,Kubo T

doi

10.1016/j.neulet.2007.01.059

subject

Has Abstract

pub_date

2007-04-12 00:00:00

pages

150-4

issue

2

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(07)00122-X

journal_volume

416

pub_type

杂志文章

相关文献

NEUROSCIENCE LETTERS文献大全
  • Prolonged exposure to bradykinin and prostaglandin E2 increases TRPV1 mRNA but does not alter TRPV1 and TRPV1b protein expression in cultured rat primary sensory neurons.

    abstract：:Sensitisation of the capsaicin receptor, transient receptor potential vanilloid type 1 (TRPV1) ion channel in nociceptive primary sensory neurons (PSN) underlies the development of inflammatory heat hyperalgesia. Removal of the negative-dominant splice variant of the TRPV1 molecule, TRPV1b from TRPV1/TRPV1b heterotetr...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2014.02.006

    authors： Mistry S,Paule CC,Varga A,Photiou A,Jenes A,Avelino A,Buluwela L,Nagy I

    更新日期：2014-04-03 00:00:00

  • Neuroprotective effects of hesperetin in mouse primary neurones are independent of CREB activation.

    abstract：:Dietary flavonoids, including the citrus flavanone hesperetin, may have stimulatory effects on cytoprotective intracellular signalling pathways. In primary mouse cortical neurone cultures, but not SH-SY5Y human neuroblastoma cells or human primary dermal fibroblasts (Promocells), hesperetin (100-300nM, 15min) caused s...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2008.04.056

    authors： Rainey-Smith S,Schroetke LW,Bahia P,Fahmi A,Skilton R,Spencer JP,Rice-Evans C,Rattray M,Williams RJ

    更新日期：2008-06-13 00:00:00

  • Intraocular colchicine selectively destroys immature ganglion cells in chicken retina.

    abstract：:Low doses of colchicine (greater than 0.5 microgram) injected into the eyes of young chickens irreversibly inhibit axonal transport of material labelled with [3H]fucose. This is due to almost total destruction of the retinal ganglion cells, while other retinal cell types, including the displaced amacrine cells found i...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(81)90167-1

    authors： Morgan IG

    更新日期：1981-07-17 00:00:00

  • Differentiating primary central nervous system lymphoma from glioma in humans using localised proton magnetic resonance spectroscopy.

    abstract：:In order to characterise primary central nervous system lymphomas (PCNSL) and to evaluate if 1H spectroscopy improves the preoperative differential diagnosis of PCNSL and glioma, seven immunocompetent patients with PCNSL and 21 patients with glioma were examined using single voxel, short echo time magnetic resonance s...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(03)00272-6

    authors： Harting I,Hartmann M,Jost G,Sommer C,Ahmadi R,Heiland S,Sartor K

    更新日期：2003-05-22 00:00:00

  • Comparison through immunoblotting of glutamic acid decarboxylase (GAD) from newborn and adult rat brain.

    abstract：:Immunochemical characterization of glutamic acid decarboxylase (GAD) from brain extracts of newborn and adult rats was investigated using a GAD antiserum that was previously raised against brain GAD from adult rats. According to the immunoprecipitation and saturation curves, no significant differences could be found a...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(89)90703-9

    authors： Henry S,Tappaz M

    更新日期：1989-05-22 00:00:00

  • Effect of professional expertise and exposure to everyday life decision-making on moral choices.

    abstract：:Moral sense is defined as a feeling of fairness or unfairness of an action that knowingly causes harm to people other than the subject. It is crucial in determining human behavior and becomes pivotal in operational environments. Here we assessed whether professional daily life experience in an operational environment ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2017.06.036

    authors： Boccia M,Verde P,Angelino G,Carrozzo P,Vecchi D,Piccardi L,Colangeli S,Cordellieri P,Ferlazzo F,Giannini AM

    更新日期：2017-07-27 00:00:00

  • Inflammation induced increase of fluoride resistant acid phosphatase (FRAP) activity in the spinal dorsal horn in rats.

    abstract：:Fluoride-resistant acid phosphatase (FRAP) has been suggested as an enzymatic marker for nociceptive primary afferent terminals in the spinal dorsal horn, however there has not been demonstrated a direct functional relation between FRAP activity and an increased nociceptive transmission. For this purpose, we quantitat...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(02)01323-x

    authors： Glykys J,Guadama M,Marcano L,Ochoa E,Eblen-Zajjur A

    更新日期：2003-02-13 00:00:00

  • Extracellular toxicity of 6-hydroxydopamine on PC12 cells.

    abstract：:6-hydroxydopamine (6-OHDA) is usually thought to cross cell membrane through dopamine uptake transporters, to inhibit mitochondrial respiration and to generate intracellular reactive oxygen species. In this study, we show that the anti-oxidants catalase, glutathione and N-acetyl-cysteine are able to reverse the toxic ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(00)00948-4

    authors： Blum D,Torch S,Nissou MF,Benabid AL,Verna JM

    更新日期：2000-04-14 00:00:00

  • Triazolam fails to induce sleep in suprachiasmatic nucleus-lesioned rats.

    abstract：:Rats with suprachiasmatic nuclei (SCN) lesions did not show increased sleep after triazolam (TRZ) injections at any dose from 0.2 to 1.6 mg/kg, whereas 0.4 mg/kg TRZ given intact rats in the middle of their activity phase significantly increased sleep. Across SCN-lesioned and intact rats, the amount of sleep before an...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(91)90007-g

    authors： Edgar DM,Seidel WF,Martin CE,Sayeski PP,Dement WC

    更新日期：1991-04-29 00:00:00

  • Regional specialization of the quail retina: ganglion cell density and oil droplet distribution.

    abstract：:The ganglion cell density of the quail's retina was studied in sections and whole mounts. Two regions of high ganglion cell density were found, corresponding to an afoveate area centralis and an area dorsalis. Oil droplets were found to be isotropically distributed throughout the retina. It is proposed that the signif...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(84)90276-3

    authors： Budnik V,Mpodozis J,Varela FJ,Maturana HR

    更新日期：1984-09-28 00:00:00

  • Ultrastructural correlates of functional relationships between nigral dopaminergic or cortical afferent fibers and neuropeptide Y-containing neurons in the rat striatum.

    abstract：:This study examines the ultrastructural relationships established by the nigrostriatal dopaminergic and the corticostriatal afferent fibers with neuropeptide Y (NPY)-containing neurons in the rat striatum. By means of dual immunolabeling procedures using peroxidase conjugated F(ab) fragments and 125I-labeled protein A...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(89)90667-8

    authors： Vuillet J,Kerkerian L,Kachidian P,Bosler O,Nieoullon A

    更新日期：1989-05-22 00:00:00

  • Persistent c-fos expression and NADPH-d reactivity in the medulla and the lumbar spinal cord in rat with short-term peripheral anosmia.

    abstract：:Here we examine hypothesis that short-term peripheral ZnSO(4)-induced anosmia can produce effects on c-fos expression within spinal cord and caudal medulla in male Wistar rats (n=4). Fos-like-immunoreactive cells revealed by avidin-biotin-peroxidase method show a significant bilateral increase in the nucleus proprius ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(01)01623-8

    authors： Kalueff AV,Maisky VA,Pilyavskii AI,Makarchuk NE

    更新日期：2001-03-30 00:00:00

  • Coupling of muscarinic receptors to GTP proteins in postmortem human brain--alterations in Alzheimer's disease.

    abstract：:The coupling of muscarinic agonist receptors to guanine nucleotide-binding (G) proteins was investigated in the frontal, temporal cortices and thalamus of control and Alzheimer brains by using carbachol in competition experiments with [3H]QNB. In the presence of GppNHp, the carbachol/[3H]QNB competition binding data s...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(93)90103-r

    authors： Warpman U,Alafuzoff I,Nordberg A

    更新日期：1993-02-05 00:00:00

  • Regulation of MHC molecules on MBP positive oligodendrocytes in mice by IFN-gamma and TNF-alpha.

    abstract：:The expression of class I and class II histocompatibility antigens by myelin basic protein (MBP)-positive oligodendrocytes, in response to exogenous cytokines, has been investigated in vitro. It has been found that interferon-gamma (IFN-gamma), although capable of class I induction, does not induce class II on oligode...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(91)90154-l

    authors： Turnley AM,Miller JF,Bartlett PF

    更新日期：1991-02-11 00:00:00

  • Muscarinic cholinergic receptors in dorsal root ganglia of chick embryo: a radioligand binding and immunocytochemical study.

    abstract：:The presence and micro-anatomical localization of muscarinic cholinergic receptors were assessed in dorsal root ganglia of chick embryo during development using radioligand binding and immunocytochemical techniques, respectively. The non-selective muscarinic cholinergic receptor radioligand [3H]quinuclidinyl benzilate...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(95)11474-b

    authors： Tata AM,Biagioni S,Ricci A,Amenta F,Augusti-Tocco G

    更新日期：1995-04-21 00:00:00

  • Noradrenergic modulation of human cortex excitability by the presynaptic alpha(2)-antagonist yohimbine.

    abstract：:The objective of this study was to determine if yohimbine, a central norepinephrine enhancing drug, increases cortico-motoneuronal excitability in intact humans. Transcranial magnetic stimulation was used to assess excitability of the motor system reflected in the parameters motor threshold, recruitment curve, intraco...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(01)01921-8

    authors： Plewnia C,Bartels M,Cohen L,Gerloff C

    更新日期：2001-07-06 00:00:00

  • Cobalt blocks postsynaptic responses induced by neurotransmitters in the hippocampus in vitro.

    abstract：:Divalent metals such as cobalt are frequently used by neurophysiologists to prevent synaptic transmission, because they are thought to selectively block presynaptic calcium conductance. Recording intracellularly from hippocampal CA3 pyramidal cells we show that Co2+ (2 mM) is not specific in this action but also dimin...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(91)90507-p

    authors： Gerber U,Gähwiler BH

    更新日期：1991-12-16 00:00:00

  • Improvement of autophagy dysfunction as a potential mechanism for environmental enrichment to protect blood-brain barrier in rats with vascular cognitive impairment.

    abstract：:Vascular cognitive impairment (VCI) is the second most common cause of dementia after Alzheimer's disease, and the cognitive impairment is one of the common effects of VCI. Unfortunately, it lacks effective therapeutic treatments at present. In our previous study, environmental enrichment (EE), as an early interventio...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2020.135437

    authors： Xu L,Qu C,Qu C,Shen J,Song H,Li Y,Li T,Zheng J,Zhang J

    更新日期：2020-11-20 00:00:00

  • A spinal projection of 5-hydroxytryptamine neurons in the lamprey brainstem; evidence from combined retrograde tracing and immunohistochemistry.

    abstract：:To investigate whether there is a descending contribution to the spinal 5-hydroxytryptamine (5-HT) innervation in the lamprey, a primitive vertebrate, a study using retrograde transport of the fluorescent tracer Fast blue combined with 5-HT immunohistochemistry was conducted. Two to 4 weeks after an injection of Fast ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(86)90207-7

    authors： Brodin L,Buchanan JT,Hökfelt T,Grillner S,Verhofstad AA

    更新日期：1986-06-06 00:00:00

  • Single systemic dose of vigabatrin induces early proconvulsant and later anticonvulsant effect in rats.

    abstract：:Vigabatrin (VGB), an inhibitor of gamma-aminobutyric acid-aminotransferase, exhibits an antiepileptic effect but several studies indicate that its effect may be biphasic. A time course of an effect of a single injection of VGB on hippocampal epileptic afterdischarges (AD) elicited by an electric stimulation of the ang...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(01)02195-4

    authors： Stuchlík A,Kubová H,Mares P

    更新日期：2001-10-12 00:00:00

  • Rat neuronal cells in primary culture as a model for nociceptin/orphanin FQ metabolism.

    abstract：:Cortical cells in primary culture contain active proteolytic enzymes capable of cleaving nociceptin/orphanin FQ (N/OFQ) and dynorphins to shorter, bioactive fragments. Cells were divided into subpopulations (neurons, astrocytes and oligodendrocytes), and the metabolic pathways in particular populations of the cells we...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0168-8278(03)00343-x

    authors： Suder P,Bogusiewicz A,Rolka K,Laidler P,Kotlinska J,Silberring J

    更新日期：2003-09-18 00:00:00

  • GWAS analysis of suicide attempt in schizophrenia: Main genetic effect and interaction with early life trauma.

    abstract：OBJECTIVES:Suicide attempt in schizophrenia is an important clinical issue. We performed a genome-wide association study to identify genetic markers, which increase the risk for suicide attempt in schizophrenia. METHODS:Suicide attempt lifetime was assessed in 121 schizophrenia patients and defined by the means of the...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2016.04.043

    authors： Bani-Fatemi A,Graff A,Zai C,Strauss J,De Luca V

    更新日期：2016-05-27 00:00:00

  • Sensitivity of pressor responses to central hypertonic saline is greatly enhanced even in pre-hypertensive spontaneously hypertensive rats.

    abstract：:It has been suggested that intracerebroventricular injection of hypertonic saline mimics the effects of a high salt diet in spontaneously hypertensive rats (SHR), a genetic model of hypertension. Intracerebroventricular injection of hypertonic saline produces an increase in blood pressure and the pressor response to h...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2006.02.002

    authors： Sasaki Y,Fujimura M,Furukawa M,Kubo T

    更新日期：2006-05-22 00:00:00

  • The effects of exercise intensity and post-exercise recovery time on cortical activation as revealed by EEG alpha peak frequency.

    abstract：:Acute physical exercise (APE) induces an increase in the individual alpha peak frequency (iAPF), a cortical parameter associated with neural information processing speed. The aim of this study was to further scrutinize the influence of different APE intensities on post-exercise iAPF as well as its time course after ex...

    journal_title：Neuroscience letters

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.neulet.2018.01.007

    authors： Gutmann B,Zimmer P,Hülsdünker T,Lefebvre J,Binnebößel S,Oberste M,Bloch W,Strüder HK,Mierau A

    更新日期：2018-03-06 00:00:00

  • Soybean agglutinin binding to the olfactory systems of the rat and mouse.

    abstract：:The binding of the lectin soybean agglutinin (SBA) to the olfactory system of both the rat and mouse was investigated histochemically. SBA bound to fibers in the accessory olfactory nerve and to glomeruli in the accessory olfactory bulb. In addition, SBA binding sites were present in some, but not all, glomeruli in th...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(86)90591-4

    authors： Key B,Giorgi PP

    更新日期：1986-08-29 00:00:00

  • Disruption of lateral olivocochlear neurons with a dopaminergic neurotoxin depresses spontaneous auditory nerve activity.

    abstract：:Neurons of the lateral olivocochlear (LOC) system project from the auditory brainstem to the cochlea, where they synapse on radial dendrites of auditory nerve fibers. Selective LOC disruption depresses sound-evoked auditory nerve activity in the guinea pig, but enhances it in the mouse. Here, LOC disruption depressed ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2014.08.040

    authors： Le Prell CG,Dolan DF,Hughes LF,Altschuler RA,Shore SE,Bledsoe SC Jr

    更新日期：2014-10-17 00:00:00

  • Pathogenic determinants and mechanisms of ALS/FTD linked to hexanucleotide repeat expansions in the C9orf72 gene.

    abstract：:Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two apparently distinct neurodegenerative diseases, the former characterized by selective loss of motor neurons in the brain and spinal cord and the latter characterized by selective atrophy of frontal and temporal lobes. Over the years, however...

    journal_title：Neuroscience letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.neulet.2016.09.007

    authors： Wen X,Westergard T,Pasinelli P,Trotti D

    更新日期：2017-01-01 00:00:00

  • NMDA receptor dependent paroxysmal discharges in the dentate gyrus.

    abstract：:The N-methyl-D-aspartic acid subclass of glutamate receptors is thought to be involved in events that depend on repetitive activation of neurons. The present study shows that repetitive stimulation of CA3 can produce epileptiform discharges in the contralateral dentate gyrus. This distinctive paroxysmal response was b...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(88)90744-6

    authors： Stringer JL,Lothman EW

    更新日期：1988-09-23 00:00:00

  • Monitoring brain activity of human subjects during delayed matching to sample tasks comparing verbal and pictorial stimuli with modal and cross-modal presentation: an event related potential study employing a source reconstruction method.

    abstract：:The time course of the event related potentials evoked within a delayed matching to sample task employing verbal and pictorial stimuli was analyzed with a source reconstruction method (minimum norm method). During signal stimulus presentation pictorial stimuli evoked more activity than verbal stimuli. Activity was par...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(98)00637-5

    authors： Dobel C,Hauk O,Zobel E,Eulitz C,Pulvermüller F,Cohen R,Schönle PW,Elbert T,Rockstroh B

    更新日期：1998-09-11 00:00:00

  • Connections between retrotrapezoid nucleus and nucleus tractus solitarii in cat.

    abstract：:The retrotrapezoid nucleus (RTN), a part of the rostral ventrolateral medulla, is involved in the control of breathing. The mechanisms by which the RTN modulate the activity of respiratory neurons during chemoreceptor stimulation are not fully understood. This electrophysiological study performed in the cat demonstrat...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(00)00770-9

    authors： Bodineau L,Frugière A,Marlot D,Wallois F

    更新日期：2000-02-18 00:00:00