Abstract:
:This study examines the ultrastructural relationships established by the nigrostriatal dopaminergic and the corticostriatal afferent fibers with neuropeptide Y (NPY)-containing neurons in the rat striatum. By means of dual immunolabeling procedures using peroxidase conjugated F(ab) fragments and 125I-labeled protein A, direct appositions and morphologically defined synaptic contacts of the symmetrical type were visualized between tyrosine hydroxylase-labeled nerve terminals and NPY-labeled neurons. After deafferentation of the striatum from its cortical input direct appositions and asymmetrical synaptic contacts were evidenced between characteristic degenerative boutons and NPY-positive neurons in the striatum. These results suggest that striatal NPY interneurons undergo direct influence from both nigrostriatal dopaminergic and corticostriatal neuronal systems.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Vuillet J,Kerkerian L,Kachidian P,Bosler O,Nieoullon Adoi
10.1016/0304-3940(89)90667-8subject
Has Abstractpub_date
1989-05-22 00:00:00pages
99-104issue
1-3eissn
0304-3940issn
1872-7972pii
0304-3940(89)90667-8journal_volume
100pub_type
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