Ultrastructural correlates of functional relationships between nigral dopaminergic or cortical afferent fibers and neuropeptide Y-containing neurons in the rat striatum.

Abstract:

:This study examines the ultrastructural relationships established by the nigrostriatal dopaminergic and the corticostriatal afferent fibers with neuropeptide Y (NPY)-containing neurons in the rat striatum. By means of dual immunolabeling procedures using peroxidase conjugated F(ab) fragments and 125I-labeled protein A, direct appositions and morphologically defined synaptic contacts of the symmetrical type were visualized between tyrosine hydroxylase-labeled nerve terminals and NPY-labeled neurons. After deafferentation of the striatum from its cortical input direct appositions and asymmetrical synaptic contacts were evidenced between characteristic degenerative boutons and NPY-positive neurons in the striatum. These results suggest that striatal NPY interneurons undergo direct influence from both nigrostriatal dopaminergic and corticostriatal neuronal systems.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Vuillet J,Kerkerian L,Kachidian P,Bosler O,Nieoullon A

doi

10.1016/0304-3940(89)90667-8

subject

Has Abstract

pub_date

1989-05-22 00:00:00

pages

99-104

issue

1-3

eissn

0304-3940

issn

1872-7972

pii

0304-3940(89)90667-8

journal_volume

100

pub_type

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