An apoE-derived mimic peptide, COG1410, alleviates early brain injury via reducing apoptosis and neuroinflammation in a mouse model of subarachnoid hemorrhage.

abstract：:Mounting evidence supports the association between a polymorphism in the serotonin transporter gene promoter region (5-HTTLPR) and suicidal behaviour. Recently, a novel variant of the 5-HTTLPR L allele was identified. The previously unknown L(G) allele produced similar levels of gene expression to the S allele and mig...

journal_title：Neuroscience letters

authors： Hung CF,Lung FW,Chen CH,O'Nions E,Hung TH,Chong MY,Wu CK,Wen JK,Lin PY

更新日期：2011-10-31 00:00:00

abstract：:Plasma studies depict collisionless, collective movements of charged particles. In touch with these concepts, originally developed by the far-flung branch of high energy physics, here we evaluate the role of collective behaviors and long-range functional couplingsof charged particlesin brain dynamics. We build a novel...

journal_title：Neuroscience letters

authors： Tozzi A,Peters JF,Déli E

更新日期：2018-01-01 00:00:00

abstract：:The effects of stress on carcinogenesis have been equivocal. The present work examined the influence of an unpredictable pattern of chronic restraint stress on estradiol-induced pituitary hyperplasia in male Fischer 344 rats. The animals were grouped as follows: (1) control, (2) stressed, (3) estradiol (31 mg), subcut...

journal_title：Neuroscience letters

authors： Gottesfeld Z,Liehr JG

更新日期：1987-09-11 00:00:00

abstract：:Neuropeptide VF (NPVF) induces satiety through hypothalamic interactions; however, the central mechanism that mediates these effects is poorly understood. Therefore, this study was conducted to explore some possible opioid receptor associated mechanisms of NPVF-induced satiety using chicks as models. Co-injection of N...

journal_title：Neuroscience letters

authors： Cline MA,Sliwa LN

更新日期：2009-05-22 00:00:00

abstract：:Hemispheric asymmetries in spatial processing are generally considered to be responsible for the shorter reaction time (RT) of the left hand classically observed for right-handers when pointing at targets. Surprisingly, despite the special role which the right cerebral hemisphere is known to play in visual attention, ...

journal_title：Neuroscience letters

authors： Barthelemy S,Boulinguez P

更新日期：2001-11-23 00:00:00

abstract：:A dimeric form of acetylcholinesterase from the electric organ of Torpedo californica was solubilized by phosphatidylinositol-specific phospholipase C from Staphylococcus aureus. The solubilized enzyme had a sedimentation coefficient of 7.3S which was not modified by detergents. The high salt-soluble asymmetric forms ...

journal_title：Neuroscience letters

authors： Futerman AH,Low MG,Silman I

更新日期：1983-09-19 00:00:00

abstract：:The pharmacokinetics of 2-amino-7-phosphonoheptanoate (AP7) in rat plasma and appearance in cerebrospinal fluid (CSF) are reported. Using high-performance liquid chromatography (HPLC) with fluorescence detection, concentrations of AP7 can be detected as low as 1.0 microM. Peak CSF concentrations (12-15 microM) for bot...

journal_title：Neuroscience letters

authors： Compton RP,Hood WF,Monahan JB

更新日期：1988-02-03 00:00:00

abstract：:This study deals with the coordination of bilateral synchronous and asynchronous hand movements. Cooperative hand movements (e.g. opening a bottle) were shown to be coordinated by a neural coupling, reflected in the appearance of reflex responses in forearm muscles of both sides to unilateral arm nerve stimulation. Th...

journal_title：Neuroscience letters

authors： Köchli S,Scharfenberger T,Dietz V

更新日期：2020-02-16 00:00:00

abstract：:Presence of substance P-like immunoreactive neurons and nerve fibers is demonstrated in the trigeminal ganglion of newborn and adult human subjects by the indirect immunofluorescence technique. Two populations of neurons containing high and low densities of immunoreactive material, respectively, are identified. Morpho...

journal_title：Neuroscience letters

authors： Del Fiacco M,Quartu M,Floris A,Diaz G

更新日期：1990-03-02 00:00:00

abstract：:We describe a novel aspect of action of memantine ex vivo, in the brain cortical slices and in vitro, in mixed glial cultures. The drug potently increased the production of kynurenic acid, an endogenous tryptophan metabolite blocking N-methyl-D-aspartate (NMDA) and nicotinic alpha7 receptors. In cortical slices memant...

journal_title：Neuroscience letters

authors： Kloc R,Luchowska E,Wielosz M,Owe-Larsson B,Urbanska EM

更新日期：2008-04-18 00:00:00

abstract：:Incorporation of the N-methyl-d-aspartate receptor (NMDAR) subunit NR3A into functional NMDARs results in reduced channel conductance and Ca(2+) permeability. To further investigate the function of NR3A, we have set out to characterize its intracellular binding partners. Here, we report a novel protein interaction bet...

journal_title：Neuroscience letters

authors： Eriksson M,Samuelsson H,Björklund S,Tortosa E,Avila J,Samuelsson EB,Benedikz E,Sundström E

更新日期：2010-05-07 00:00:00

abstract：:Basal and interferon (IFN)-induced levels of (2'-5') oligoadenylate synthetase activity were measured in astrocyte cultures from the mouse cerebral cortex, in neurone-enriched and mixed cerebellar cultures, and in two continuous neural cell lines by a radioimmunoassay procedure. All untreated cultures contained measur...

journal_title：Neuroscience letters

authors： Hirsch MR,Cailla H,Wietzerbin J,Goridis C

更新日期：1986-04-11 00:00:00

abstract：:We have demonstrated the existence and localization of two angiotensin II (AII) receptor subtypes in different regions of the rat brain using competitive radioligand binding technique. The identification of the subtypes was made by the reciprocal selectivity of DuP 753 and PD123177 for the AII-1 and AII-2 receptors, r...

journal_title：Neuroscience letters

authors： Leung KH,Smith RD,Pieter,Timmermans BM,Chiu AT

更新日期：1991-02-11 00:00:00

abstract：:The IKK/NF-κB signalling pathway plays a predominant role in the regulation of inflammation and apoptosis in spinal cord injury (SCI). We have previously demonstrated that targeting of the IKK/NF-κB pathway improved the recovery of locomotor function by reducing the infiltration of inflammatory cells and apoptosis aft...

journal_title：Neuroscience letters

authors： Lu M,Wang S,Han X,Lv D

更新日期：2013-05-10 00:00:00

abstract：:The effects of methysergide (1 mg, p.o.), clonidine (50 micrograms, i.m.) and methysergide plus clonidine on growth hormone (GH) and prolactin (PRL) secretion in 8 normal male volunteers have been studied. Both methysergide and clonidine were found to enhance GH and to lower PRL plasma levels. The effects of methyserg...

journal_title：Neuroscience letters

authors： Agnati LF,Benfenati F,Capelli M,Cocchi V,D'Errico A,Bernardi P

更新日期：1981-02-06 00:00:00

abstract：:Neurons in the ipsilateral anteropolar division of the zona incerta were retrogradely labeled following injections of horseradish peroxidase in the main olfactory bulb. In addition, labeled cell bodies were found in the dorsal hypothalamus. Fewer and less densely labeled neuron cell bodies were seen in the contralater...

journal_title：Neuroscience letters

authors： Uemura-Sumi M,Osterstock J,Millhouse OE

更新日期：1985-02-04 00:00:00

abstract：:We have s.c. injected with kainic acid (12 mg/kg) normal adult rats as well as rats rendered microencephalic by selectively timed administration of the DNA alkylating agent methylazoxymethanol acetate (MAM) to the mother during pregnancy. Histological examination of the brains revealed that normal animals underwent ne...

journal_title：Neuroscience letters

authors： Virgili M,Ciani E,Contestabile A

更新日期：1996-10-25 00:00:00

abstract：:The endogenously synthesized nonapeptide arginine vasopressin (AVP) is thought to be involved in transduction of photic information to the pineal gland. The enhancement of circulating AVP leads to a suppression of the nocturnal melatonin surge the mechanisms of which are unknown so far. We therefore studied the effect...

journal_title：Neuroscience letters

authors： Stehle J,Reuss S,Riemann R,Seidel A,Vollrath L

更新日期：1991-02-11 00:00:00

abstract：:Gap junction (GJ) coupling between neocortical GABAergic interneurons plays a critical role in the synchronization of activity in cortical networks in physiological and pathophysiological states, e.g., seizures. Past studies have shown that GJ blockers exert anticonvulsant actions in both in vivo and in vitro models o...

journal_title：Neuroscience letters

authors： Yang L,Ling DS

更新日期：2007-04-18 00:00:00

abstract：:The expression of neuronal type of nitric oxide synthase (nNOS) has been studied by immunocytochemistry in the brain of rats receiving a single daily (for up to 14 consecutive days) intracerebroventricular (i.c.v.) injection of the HIV-1 recombinant protein gp 120 (100 ng/day). This treatment failed to affect nNOS exp...

journal_title：Neuroscience letters

authors： Bagetta G,Corasaniti MT,Costa N,Berliocchi L,Finazzi-Agrò A,Nisticò G

更新日期：1997-03-14 00:00:00

abstract：:In our horseradish peroxidase (HRP) study of the afferents to the medullary raphe nuclei in the cat, HRP uptake by damaged axons en route to the inferior olive (IO) was thought to be responsible for retrograde labelling of specific midbrain nuclei. To control for such indirect labelling, HRP was injected iontophoretic...

journal_title：Neuroscience letters

authors： Abols IA,Basbaum AI

更新日期：1979-07-01 00:00:00

abstract：:We previously identified a novel molecule "Shati/Nat8l" from the nucleus accumbens of mice. However, the physiological roles of the SHATI protein are not clear. To investigate the effect of SHATI on the central nervous system and behavior, we studied knockout mice of this protein. We carried out various behavior tests...

journal_title：Neuroscience letters

authors： Furukawa-Hibi Y,Nitta A,Fukumitsu H,Somiya H,Toriumi K,Furukawa S,Nabeshima T,Yamada K

更新日期：2012-09-27 00:00:00

abstract：:Bilateral, radiofrequency destruction of the hypothalamic paraventricular nucleus resulted in a pronounced depression in levels of immunoreactive (ir-) vasopressin (VP) in the medulla-pons of rats. The contents of ir-dynorphin1-17 (DYN), ir-DYN1-8 and ir-alpha-neo-endorphin (alpha-NE) therein were not, in contrast, af...

journal_title：Neuroscience letters

authors： Millan MH,Millan MJ,Herz A

更新日期：1982-12-30 00:00:00

abstract：:The effects of treadmill exercise training on prepro-galanin (GAL) and tyrosine hydroxylase (TH) gene expression in the locus coeruleus (LC) were examined. Male Fischer-344 rats (n=9) were assigned to 6 weeks of treadmill running. An additional group of animals comprised the sedentary home cage control group (n=9). Le...

journal_title：Neuroscience letters

authors： O'Neal HA,Van Hoomissen JD,Holmes PV,Dishman RK

更新日期：2001-02-16 00:00:00

abstract：:Argiotoxin636, a component of the spider venom of argiope species, was chemically synthesized together with a number of derivatives in order to analyse their blocking activity on mammalian glutamate receptors. Xenopus laevis oocytes injected with rat brain mRNA served as assay system. The results showed that argiotoxi...

journal_title：Neuroscience letters

authors： Draguhn A,Jahn W,Witzemann V

更新日期：1991-11-11 00:00:00

abstract：:Chronic stress results in neurological complications like depression, cognitive dysfunction, and anxiety disorders. In our previous study, we observed that Urtica dioica leaf extract attenuated chronic stress-induced complications. Further, we observed that Urtica dioica contained a great amount of the flavonoid rutin...

journal_title：Neuroscience letters

authors： Parashar A,Mehta V,Udayabanu M

更新日期：2017-08-24 00:00:00

abstract：:The mechanisms underlying alterations in brain functions in response to physical exercise are not fully understood. The present study examined the central effect of irisin, a 112 amino acid polypeptide hormone secreted from the skeletal muscle after exercise, on the locomotion in rats. Central administration of irisin...

journal_title：Neuroscience letters

authors： Zhang W,Chang L,Zhang C,Zhang R,Li Z,Chai B,Li J,Chen E,Mulholland M

更新日期：2015-05-19 00:00:00

abstract：:The 22Na+ efflux stimulated by selected agonists of the 4 excitatory amino acid receptors, previously detected in the striatum, has been studied on 22Na+-preloaded slices prepared from 10 major areas of the rat brain. All brain areas were found to be sensitive, albeit to varying extents, to excitatory amino acids. The...

journal_title：Neuroscience letters

authors： Luini A,Goldberg O,Teichberg VI

更新日期：1983-11-11 00:00:00

abstract：:Although first mentions about calcium disturbances in psychiatric diseases appeared more than 30 years ago, the most recent genomic and proteomic findings confirmed a significant role of Ca2+ and Ca2+-regulated pathways in development of neuropathological processes, including bipolar disorder and schizophrenia. Moreov...

journal_title：Neuroscience letters

authors： Lisek M,Boczek T,Zylinska L

更新日期：2018-01-10 00:00:00

abstract：:Simultaneous recordings of cortical activity, recorded as the cortical local field potential (CLFP) in the contralateral posterior sigmoid gyrus, and the spinal activity, recorded as the cord dorsum potential (CDP) of the L6 lumbar segment, were made in the anaesthetized cat. The electrodes were positioned in somatose...

journal_title：Neuroscience letters

authors： Manjarrez E,Rojas-Piloni G,Vazquez D,Flores A

更新日期：2002-02-01 00:00:00