Abstract:
:The effects of methysergide (1 mg, p.o.), clonidine (50 micrograms, i.m.) and methysergide plus clonidine on growth hormone (GH) and prolactin (PRL) secretion in 8 normal male volunteers have been studied. Both methysergide and clonidine were found to enhance GH and to lower PRL plasma levels. The effects of methysergide are explained on the basis of a preferential action of methysergide metabolites on dopamine receptors, whereas the effects of clonidine are attributed to a stimulatory action on adrenaline receptors. The combined treatment methysergide plus clonidine resulted in a potentiation of the effects caused by the drugs when administered alone.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Agnati LF,Benfenati F,Capelli M,Cocchi V,D'Errico A,Bernardi Pdoi
10.1016/0304-3940(81)90226-3subject
Has Abstractpub_date
1981-02-06 00:00:00pages
333-8issue
3eissn
0304-3940issn
1872-7972pii
0304-3940(81)90226-3journal_volume
21pub_type
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