Abstract:
:HS-142-1 is a novel non-peptide antagonist for atrial natriuretic peptide (ANP) receptor. The effect of HS-142-1 on the cyclic GMP production elicited by natriuretic peptides in neuronal cell lines, PC12 and NG108-15 was examined. Natriuretic peptides such as ANP, brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP) enhanced cyclic GMP production in a dose-dependent manner. HS-142-1 inhibited cyclic GMP accumulation elicited by natriuretic peptides in a dose-dependent fashion in both cells. The results suggest that HS-142-1 will be an important tool for identification and understanding of the mechanisms by which natriuretic peptides act in nervous systems.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Toki S,Morishita Y,Sano T,Matsuda Ydoi
10.1016/0304-3940(92)90149-2keywords:
subject
Has Abstractpub_date
1992-01-20 00:00:00pages
117-20issue
1eissn
0304-3940issn
1872-7972pii
0304-3940(92)90149-2journal_volume
135pub_type
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