Hyperforin enhances the extracellular concentrations of catecholamines, serotonin and glutamate in the rat locus coeruleus.

abstract：:The effects of electrical stimulation of the central (CE) and basolateral (BL) amygdaloid nuclei on pancreatic exocrine secretion were tested in urethane-anesthetized rats. Electrical stimulation (0.1 mA, 1 ms, 40 Hz) of the CE significantly increased basal and hormone (secretin+cholecystokinin-8)-infused pancreatic e...

journal_title：Neuroscience letters

authors： Hahn SJ,Yoon SH,Sim SS,Rhie DJ,Jo YH,Kim MS

更新日期：1994-03-14 00:00:00

abstract：:The Nef protein of human immunodeficiency virus type 1 (HIV-1) is abundantly expressed in HIV-1-infected astrocytes and shares amino acid sequence homology to alpha-scorpion toxins which bind to potassium channels. Here we report effects of recombinant Nef and alpha-scorpion toxins on membrane potassium transport in h...

journal_title：Neuroscience letters

authors： Kort JJ,Jalonen TO

更新日期：1998-07-17 00:00:00

abstract：:The reactivity of different narrow electroencephalographic (EEG) frequencies (4-6, 6-8, 8-10 and 10-12 Hz) to three types of emotionally laden film clips (aggressive, sad, neutral) were examined. We observed that different EEG frequency bands responded differently to the three types of film content. In the 4-6 Hz freq...

journal_title：Neuroscience letters

authors： Krause CM,Viemerö V,Rosenqvist A,Sillanmäki L,Aström T

更新日期：2000-05-26 00:00:00

abstract：:Cyclosporine A (CsA) is the major immunosuppressive drug used for organ and neural transplantation and the therapy of selected autoimmune diseases. We investigated the effect of CsA on the activity of acetylcholinesterase (AChE) in the frontal cortex, hippocampus, septum, and basal ganglia. AChE was determined spectro...

journal_title：Neuroscience letters

authors： Herink J,Krejcová G,Bajgar J,Svoboda Z,Kvĕtina J,Zivnú P,Palicka V

更新日期：2003-03-27 00:00:00

abstract：:Neuroinflammation can lead to either damage of astrocytes or astrogliosis. Astrocyte loss may be caused by cytotoxic T cells as seen in Rasmussen encephalitis, auto-antibodies such as in neuromyelitis optica (aquaporin-4 antibodies), or cytokines such as TNF-α in major depressive disorder. Interleukins-1 and -6 appear...

journal_title：Neuroscience letters

authors： Hostenbach S,Cambron M,D'haeseleer M,Kooijman R,De Keyser J

更新日期：2014-04-17 00:00:00

abstract：:Rat neocortical slices maintained in Mg2(+)-free Krebs medium developed spontaneous paroxysmal discharges which were attenuated or suppressed by the gamma-aminobutyric acid-B (GABAB) receptor agonist baclofen, occasionally accompanied by a slight hyperpolarisation, and antagonised by the specific GABAB-receptor antago...

journal_title：Neuroscience letters

authors： Ong J,Kerr DI,Johnston GA,Hall RG

更新日期：1990-02-05 00:00:00

abstract：:Numerous studies have demonstrated that learning and memory abilities in the course of normal aging cognitive abilities tend to decline and Nrf2 expression appears to decline with aging. So, Nrf2 pathway has been identified as a promising therapeutic target for neurodegenerative diseases. The organosulfur compounds, a...

journal_title：Neuroscience letters

authors： Li XH,Li CY,Lu JM,Tian RB,Wei J

更新日期：2012-04-11 00:00:00

abstract：:To evaluate the roles of complement in kainic acid (KA)-induced neuronal damages, the immunohistochemical localization of the complement protein C3 was examined in rat hippocampus after systemic KA injection. The immunoreactivity for C3 was found in glial cells in control rats, and such glial cells were increased in n...

journal_title：Neuroscience letters

authors： Morita H,Suzuki K,Mori N,Yasuhara O

更新日期：2006-11-27 00:00:00

abstract：:Superoxide dismutase 1 (SOD1) aggregates are a histological and biochemical correlate of disease progression in neural tissues from mutant SOD1-linked forms of familial amyotrophic lateral sclerosis (FALS). In the present study, we assayed the monomeric and high molecular weight mutant SOD1 content of nervous, muscle ...

journal_title：Neuroscience letters

authors： Turner BJ,Lopes EC,Cheema SS

更新日期：2003-10-23 00:00:00

abstract：:To determine the role of cytokines in the nervous system, we examined the effect of interleukin-12(IL-12) on the nerve regeneration of mouse superior cervical ganglion cells (SCG). IL-12 enhanced the neurite outgrowth in a concentration-dependent manner. Immunocytochemical studies demonstrated the expression of IL-12 ...

journal_title：Neuroscience letters

authors： Lin H,Hikawa N,Takenaka T,Ishikawa Y

更新日期：2000-01-14 00:00:00

abstract：:Parkinson's disease (PD) is a progressive age-related debilitating motor disorder and the second most common neurodegenerative disease after Alzheimer's disease. In this study, we aimed to investigate the expression of 24 candidate miRNAs in PD and to assess their diagnostic value in patients with PD. We collected ser...

journal_title：Neuroscience letters

authors： Cao XY,Lu JM,Zhao ZQ,Li MC,Lu T,An XS,Xue LJ

更新日期：2017-03-22 00:00:00

abstract：:The magnocellular neurones of the supraoptic nucleus (SON) and paraventricular nucleus release neuropeptide from their axon terminals and also from their dendrites. In the axon terminals, swellings known as Herring bodies are responsible for the degradation of aged, unreleased large dense-cored vesicles (LDCVs) by lys...

journal_title：Neuroscience letters

authors： Monteiro O,Wiegand UK,Ludwig M

更新日期：2011-02-01 00:00:00

abstract：:Pain-related evoked potentials (PREP) is an established electrophysiological method to evaluate the signal transmission of electrically stimulated A-delta fibres. Although prerequisite for its clinical use, test-retest-reliability and side-to-side differences of bilateral stimulation in healthy subjects have not been ...

journal_title：Neuroscience letters

authors： Özgül ÖS,Maier C,Enax-Krumova EK,Vollert J,Fischer M,Tegenthoff M,Höffken O

更新日期：2017-04-24 00:00:00

abstract：:Five picrotoxinin analogues were examined on GABA-gated chloride channels of an identifiable cockroach (Periplaneta americana) motor neurone (Df). Substitution of the bridgehead hydroxyl at the C-6 position of the picrotoxinin molecule by a fluorine atom (fluoropicrotoxinin) had little effect, whereas acetylation of t...

journal_title：Neuroscience letters

authors： Anthony NM,Holyoke CW Jr,Sattelle DB

更新日期：1994-04-25 00:00:00

abstract：:We determined the concentrations of the putative transmitter amino acids in the cerebrospinal fluid of patients with Alzheimer type dementia (ATD) and vascular dementia of the Binswanger type (VDBT). In ATD, aspartate and glutamate concentrations were significantly and selectively reduced, while in VDBT, concentration...

journal_title：Neuroscience letters

authors： Tohgi H,Abe T,Takahashi S,Kimura M

更新日期：1992-07-06 00:00:00

abstract：:Gamma gamma (gamma gamma) enolase amount and enolase isozyme activities were measured in brain structures involved in stress response (hypothalamic paraventricular and supraoptic nuclei, locus coeruleus, hippocampus, A1 and A2 regions, hypophysis). Analyses were made in rats after immobilization or adrenalectomy, two ...

journal_title：Neuroscience letters

authors： Sanne JL,Scarna H,Grange E,Bobillier P

更新日期：1990-10-30 00:00:00

abstract：:Deposition of amyloid beta (A beta) is one of the pathological hallmarks of brains affected with Alzheimer's disease (AD). The accumulation of A beta have been observed in human myopathies with rimmed vacuoles (RVs) which might involve lysosomal function. Chloroquine, a potent lysosomotropic agent, induces muscle path...

journal_title：Neuroscience letters

authors： Tsuzuki K,Fukatsu R,Takamaru Y,Kimura K,Abe M,Shima K,Fujii N,Takahata N

更新日期：1994-12-05 00:00:00

abstract：:Silver staining (Bodian procedure) in the nucleus of the sublenticular substantia innominata (SI), also referred to as the nucleus basalis of Meynert, was evaluated in autopsy material from patients with Alzheimer's disease or senile dementia of the Alzheimer type (age at death: mean 69 years, range 63 to 81 years; ti...

journal_title：Neuroscience letters

authors： Jacobs RW,Farivar N,Butcher LL

更新日期：1985-05-23 00:00:00

abstract：:Astrocytes in the CNS produce inflammatory mediators in response to several stimuli and cytokines. Here we investigated the in vitro effect of leptin on inducible nitric oxide synthase (iNOS) expression in a glioma cell line (C6). After hormone stimulation, culture media were analysed for accumulated stable oxidation ...

journal_title：Neuroscience letters

authors： Mattace Raso G,Esposito E,Iacono A,Pacilio M,Coppola A,Bianco G,Diano S,Di Carlo R,Meli R

更新日期：2006-03-27 00:00:00

abstract：:Chondroitin sulfate/dermatan sulfate (CS/DS) polysaccharides have been reported to play a crucial role in the proliferation and maintenance of neural stem cells (NSCs). However, little is known about the structural changes and functional role of CS/DS chains in the differentiation of NSCs. Western blots of NSCs, neuro...

journal_title：Neuroscience letters

authors： Yamauchi S,Kurosu A,Hitosugi M,Nagai T,Oohira A,Tokudome S

更新日期：2011-04-15 00:00:00

abstract：:In vivo differential pulse voltammetry with carbon fiber electrodes was used to monitor extracellular 5-hydroxyindoleacetic acid (5-HIAA) levels in a serotonergic denervated target area, the striatum, before and after transplantation of mesencephalic raphé nuclei into the lateral ventricle in the rat. The amplitude of...

journal_title：Neuroscience letters

authors： McRae-Degueurce A,Serrano A,Sandillon F,Privat A,Scatton B

更新日期：1984-07-27 00:00:00

abstract：:Morphine and other opioids have direct analgesic actions in the spinal cord and chronic spinal administration of opioid agonists is used clinically in patients suffering from severe, chronic pain. Neuropathic pain resulting from peripheral nerve injury is often less sensitive to opioid therapy than other forms of chro...

journal_title：Neuroscience letters

authors： Stone LS,Vulchanova L,Riedl MS,Williams FG,Wilcox GL,Elde R

更新日期：2004-05-06 00:00:00

abstract：:We immunohistochemically investigated the degeneration processes of the nigro-striatal and nigro-amygdaloid pathways and the relationship between the loss of dopaminergic neurons and Lewy bodies (LB) formation in the substantia nigra using 15 autopsied cases of dementia with Lewy bodies (DLB). The number of tyrosine h...

journal_title：Neuroscience letters

authors： Iseki E,Marui W,Yamamoto R,Togo T,Katsuse O,Kato M,Iwatsubo T,Kosaka K,Arai H

更新日期：2005-05-20 00:00:00

abstract：:Alzheimer's disease (AD) is a complex disease with the possible involvement of several genes. Genetic studies on sporadic late-onset AD have determined APOE*4 to be the major risk factor. Members of the synuclein gene family are potential candidates for the risk of AD. The persyn gene (gamma-synuclein) has recently be...

journal_title：Neuroscience letters

authors： Luedecking EK,Ganguli M,DeKosky ST,Kamboh MI

更新日期：1999-02-19 00:00:00

abstract：:The distribution of neurons containing the messenger RNA encoding preprotachykinin, the precursor of the neuropeptides substance P and K, was examined in the striatum of the rat. The large majority of cells densely labelled by in situ hybridization histochemistry (using a 35S-radiolabelled RNA probe complementary of t...

journal_title：Neuroscience letters

authors： Chesselet MF,Robbins E

更新日期：1989-01-02 00:00:00

abstract：:Intracellular recordings were made in slices of human neocortex removed for surgical treatment of epilepsy. In response to prolonged suprathreshold current injection, regular spiking neurons (67.5% of sample) responded by repetitive firing throughout the stimulus from all membrane potentials. Bursting neurons (32.5% o...

journal_title：Neuroscience letters

authors： Foehring RC,Wyler AR

更新日期：1990-03-14 00:00:00

abstract：:The adenosine triphosphate (ATP)-dependent sodium/potassium pump extrudes intracellular sodium in exchange for extracellular potassium. Low ATP causes pump dysfunction increasing both intracellular sodium and water thereby enhancing metabolite mobility. This should be detectable by proton magnetic resonance spectrosco...

journal_title：Neuroscience letters

authors： Cady EB,Lorek A,Penrice J,Wylezinska M,Cooper CE,Brown GC,Owen-Reece H,Kirkbride V,Wyatt JS,Osmund E

更新日期：1994-12-05 00:00:00

abstract：:Ample evidence has been reported to show a probable contribution of orexin in the central cardiovascular regulation. Although cardiovascular and respiratory centers in the brain are located close to each other and are interconnected, the possible participation of orexin in respiratory regulation has not been fully doc...

journal_title：Neuroscience letters

authors： Zhang W,Fukuda Y,Kuwaki T

更新日期：2005-09-09 00:00:00

abstract：:In this study, we have developed a microarray including 1467 cDNAs that were selected to specifically measure stress response in peripheral blood leukocytes. Venous blood was collected from 10 graduate students 2 h before and 2 or 24 h after an open presentation for their Ph.D. The mRNA levels in leukocytes were compa...

journal_title：Neuroscience letters

authors： Morita K,Saito T,Ohta M,Ohmori T,Kawai K,Teshima-Kondo S,Rokutan K

更新日期：2005-06-10 00:00:00

abstract：:The depression of the amplitude of extracellularly recorded monosynaptic excitatory field potentials in the lumbar spinal cord of pentobarbitone anaesthetised rats and cats by three thienyl derivatives of GABA: 4-amino-3-(2-thienyl)-butanoic acid; 4-amino-3-(2-thienyl-5-methyl)-butanoic acid and 4-amino-3-(2-thienyl-5...

journal_title：Neuroscience letters

authors： Lacey G,Berthelot P,Vaccher C,Flouquet N,Vaccher MP,Debaert M,Curtis DR

更新日期：1993-09-03 00:00:00