Abstract:
:The distribution of neurons containing the messenger RNA encoding preprotachykinin, the precursor of the neuropeptides substance P and K, was examined in the striatum of the rat. The large majority of cells densely labelled by in situ hybridization histochemistry (using a 35S-radiolabelled RNA probe complementary of the beta-preprotachykinin mRNA) were located within the boundaries of areas of dense [3H]naloxone binding which delineate the striosomes, a striatal compartment distinct from the surrounding matrix with respect to its inputs, outputs and neurochemical content. In view of previous immunohistochemical data, the results suggest that tachykinin-containing neurons of the striosomes have a higher rate of tachykinin synthesis than those neurons located in the surrounding striatal matrix.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Chesselet MF,Robbins Edoi
10.1016/0304-3940(89)90241-3subject
Has Abstractpub_date
1989-01-02 00:00:00pages
47-53issue
1eissn
0304-3940issn
1872-7972pii
0304-3940(89)90241-3journal_volume
96pub_type
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