Abstract：
:The magnocellular neurones of the supraoptic nucleus (SON) and paraventricular nucleus release neuropeptide from their axon terminals and also from their dendrites. In the axon terminals, swellings known as Herring bodies are responsible for the degradation of aged, unreleased large dense-cored vesicles (LDCVs) by lysosomes. Dendrites of magnocellular neurones also contain a large number of LDCVs but specialised areas of vesicle degradation have yet to be discovered. Using immunofluorescence labelling for lysosomes in vasopressin-enhanced green fluorescent protein (vasopressin-eGFP) transgenic rats, we found that lysosomes are preferentially located in the centre of the dendrites where there was a high density of vasopressin-eGFP expression. These data suggest that there are local "hot spots", but not specific compartments for vesicle degradation in magnocellular dendrites.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Monteiro O,Wiegand UK,Ludwig Mdoi
10.1016/j.neulet.2010.11.060subject
Has Abstractpub_date
2011-02-01 00:00:00pages
30-3issue
1eissn
0304-3940issn
1872-7972pii
S0304-3940(10)01514-4journal_volume
489pub_type
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