Abstract:
:In this study, we have developed a microarray including 1467 cDNAs that were selected to specifically measure stress response in peripheral blood leukocytes. Venous blood was collected from 10 graduate students 2 h before and 2 or 24 h after an open presentation for their Ph.D. The mRNA levels in leukocytes were compared with those prepared 4 weeks before the presentation. Hierarchical cluster showed that distinct groups of genes uniformly changed their expression values in response to the stress. Bayesian t test identified significantly up-regulated 49 genes and down-regulated 21 genes. Most of them are categorized into cytokines, cytokine receptors, growth- or apoptosis-related molecules, and heat shock proteins, suggesting that stressful life events trigger acute responses in leukocytes. Our results suggest that gene expression profile in peripheral blood leukocytes may be a potentially useful method for the assessment of complex stress responses.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Morita K,Saito T,Ohta M,Ohmori T,Kawai K,Teshima-Kondo S,Rokutan Kdoi
10.1016/j.neulet.2005.01.081keywords:
subject
Has Abstractpub_date
2005-06-10 00:00:00pages
57-62issue
1-2eissn
0304-3940issn
1872-7972pii
S0304-3940(05)00143-6journal_volume
381pub_type
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