Excitation and sensitization of the heat response induced by a phorbol ester in canine visceral polymodal receptors studied in vitro.

Abstract:

:To clarify the possible involvement of protein kinase (PK) C activation in the excitation and sensitization of polymodal receptors (PMRs), the effects of phorbol 12,13-dibutyrate (PDBu) on PMRs were studied in canine testis-spermatic nerve preparations in vitro. Application of PDBu (10(-7), 10(-6), AND 10(-5) M) for 5 min evoked a significant increase in the ongoing activity of the PMRs within 15 min. PDBu (10(-8) to 10(-5) M) significantly augmented the subsequent heat responses of the PMRs. Staurosporine (10(-6) M), a PK inhibitor, attenuated the effect of PDBu on heat responses. These data suggest that activation of PKC contributes to the activities of PMRs.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Leng S,Mizumura K,Koda H,Kumazawa T

doi

10.1016/0304-3940(96)12414-9

subject

Has Abstract

pub_date

1996-03-08 00:00:00

pages

13-6

issue

1

eissn

0304-3940

issn

1872-7972

pii

0304394096124149

journal_volume

206

pub_type

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