Abstract:
:Our previous study demonstrated that successive electroacupuncture (EA) at ST36 acupoint reduces IgE production in BALB/c mice immunized with 2,4-dinitrophenylated keyhole limpet protein (DNP-KLH) by suppression of the Th2 cell lineage development. Here, we report that pretreatment of phentolamine (alpha-adrenoceptor antagonist, 10mg/kg, i.p.) completely blocks the EA-induced suppression of antigen-specific and total IgE levels in serum and IL-4 production in anti-CD3 mAb-activated splenocytes in DNP-KLH immunized mice. The results suggest that alpha-adrenoceptor play an important role in mediating the suppressive effects of EA on IgE production and Th2 cell response in DNP-KLH immunized mice.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Lee Y,Kim SK,Kim Y,Lee H,Shin MK,Hong MC,Min BI,Bae Hdoi
10.1016/j.neulet.2007.07.002subject
Has Abstractpub_date
2007-08-16 00:00:00pages
149-52issue
2eissn
0304-3940issn
1872-7972pii
S0304-3940(07)00773-2journal_volume
423pub_type
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