The alpha-adrenoceptor mediation of the immunomodulatory effects of electroacupuncture in DNP-KLH immunized mice.

Abstract:

:Our previous study demonstrated that successive electroacupuncture (EA) at ST36 acupoint reduces IgE production in BALB/c mice immunized with 2,4-dinitrophenylated keyhole limpet protein (DNP-KLH) by suppression of the Th2 cell lineage development. Here, we report that pretreatment of phentolamine (alpha-adrenoceptor antagonist, 10mg/kg, i.p.) completely blocks the EA-induced suppression of antigen-specific and total IgE levels in serum and IL-4 production in anti-CD3 mAb-activated splenocytes in DNP-KLH immunized mice. The results suggest that alpha-adrenoceptor play an important role in mediating the suppressive effects of EA on IgE production and Th2 cell response in DNP-KLH immunized mice.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Lee Y,Kim SK,Kim Y,Lee H,Shin MK,Hong MC,Min BI,Bae H

doi

10.1016/j.neulet.2007.07.002

subject

Has Abstract

pub_date

2007-08-16 00:00:00

pages

149-52

issue

2

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(07)00773-2

journal_volume

423

pub_type

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