Age-related changes in HSP25 expression in basal ganglia and cortex of F344/BN rats.

abstract：:Although Streptococcus pneumoniae is the major cause of meningitis, how it causes disease is poorly understood. The C-type lectin SIGN-R1 mediates the recently described SIGN-R1 complement activation pathway, which operates against capsular polysaccharides (CPSs) of S. pneumoniae in splenic marginal macrophages. Here,...

journal_title：Neuroscience letters

authors： Park JY,Choi HJ,Prabagar MG,Choi WS,Kim SJ,Cheong C,Park CG,Chin CY,Kang YS

更新日期：2009-02-06 00:00:00

abstract：:Outcome following traumatic brain injury (TBI) is in large part determined by the combined action of multiple processes. In order to better understand the response of the central nervous system to injury, we utilized an antibody array to simultaneously screen 507 proteins for altered expression in the injured hippocam...

journal_title：Neuroscience letters

authors： Redell JB,Dash PK

更新日期：2007-02-08 00:00:00

abstract：:Cyclins are regulatory proteins of the cell cycle which bind and activate kinases. In gliomas, contrary to many malignancies, cyclin D1 is rarely amplified, but together with other cyclins, it increases with anaplasia. In a series of 23 surgical biopsies of grade II and III oligodendroglioma, cyclin D1, E, A, B1, CDK4...

journal_title：Neuroscience letters

authors： Fiano V,Ghimenti C,Schiffer D

更新日期：2003-08-21 00:00:00

abstract：:In micturition control, the roles of ionotropic glutamate (iGlu) receptors NMDA and AMPA are well established, whereas little is known about the function of metabotropic glutamate (mGlu) receptors. Since antagonists for mGlu5 receptors are efficacious in animal models of inflammatory and neuropathic pain, we examined ...

journal_title：Neuroscience letters

authors： Hu Y,Dong L,Sun B,Guillon MA,Burbach LR,Nunn PA,Liu X,Vilenski O,Ford AP,Zhong Y,Rong W

更新日期：2009-01-23 00:00:00

abstract：:Recently, the gene called DAAO was reported to be associated with schizophrenia in the French Canadian populations. Here, we report a result obtained in the study of our large collection of 547 schizophrenia cases and 536 controls in the Chinese population. Six single-nucleotide polymorphisms (SNPs) were genotyped at ...

journal_title：Neuroscience letters

authors： Liu X,He G,Wang X,Chen Q,Qian X,Lin W,Li D,Gu N,Feng G,He L

更新日期：2004-10-21 00:00:00

abstract：:Tetrahydroaminoacridine (THA) has recently been reported to be more useful in the treatment of Alzheimer's disease than physostigmine. A comparison of the effects of these two anticholinesterase agents on in vitro enzyme and receptor activities of human cerebral cortex (obtained at autopsy) revealed similarities in th...

journal_title：Neuroscience letters

authors： Perry EK,Smith CJ,Court JA,Bonham JR,Rodway M,Atack JR

更新日期：1988-08-31 00:00:00

abstract：:Serum choline concentrations decrease during and after surgery. We undertook this study to determine whether the decrease of choline is associated with an increase in stress hormones. In 16 patients undergoing abdominal surgery with general anesthesia, circulating choline cortisol, prolactin, adrenocorticotropic hormo...

journal_title：Neuroscience letters

authors： Ozarda Ilçöl Y,Ozyurt G,Kilicturgay S,Uncu G,Ulus IH

更新日期：2002-05-10 00:00:00

abstract：:Deposition of amyloid beta (A beta) is one of the pathological hallmarks of brains affected with Alzheimer's disease (AD). The accumulation of A beta have been observed in human myopathies with rimmed vacuoles (RVs) which might involve lysosomal function. Chloroquine, a potent lysosomotropic agent, induces muscle path...

journal_title：Neuroscience letters

authors： Tsuzuki K,Fukatsu R,Takamaru Y,Kimura K,Abe M,Shima K,Fujii N,Takahata N

更新日期：1994-12-05 00:00:00

abstract：:The nerve growth factor (NGF) precursor protein proNGF is the predominant NGF moiety found in the human neocortex and exhibits pro-apoptotic properties when bound to the p75(NTR) neurotrophin receptor in the presence of sortilin, a Vps10p domain trafficking protein. Recently studies have shown that proNGF levels incre...

journal_title：Neuroscience letters

authors： Mufson EJ,Wuu J,Counts SE,Nykjaer A

更新日期：2010-03-08 00:00:00

abstract：:FOXP2, the first gene known to be involved in the development of speech and language, can be considered to be, a priori, a candidate gene in schizophrenia, given the mounting evidence that the underlying core deficit in this disease could be a failure of structures relevant to normal language processing. To investigat...

journal_title：Neuroscience letters

authors： Španiel F,Horáček J,Tintěra J,Ibrahim I,Novák T,Čermák J,Klírová M,Höschl C

更新日期：2011-04-15 00:00:00

abstract：:Muscle vibration does not affect post-synaptic excitability of the corresponding motoneuronal pool, the concurrent depression of the monosynaptic reflex resulting from a pre-motoneuronal block of Ia spindle afferents. Indeed (1) both homonymous and heteronymous soleus responses (to electrical stimulation of the poster...

journal_title：Neuroscience letters

authors： Abbruzzese M,Minatel C,Faga D,Favale E

更新日期：1997-08-08 00:00:00

abstract：:The distribution of Purkinje cells projecting to the descending vestibular nucleus was studied in lobule IX (uvula) of the cat by the retrograde wheat germ agglutinin-horseradish peroxidase method. In the transverse plane labeled Purkinje cells were seen diffusely within 1.0 mm from the midline and densely for 250-500...

journal_title：Neuroscience letters

authors： Matsushita M,Wang CL

更新日期：1986-05-23 00:00:00

abstract：:Recombinant gamma-aminobutyric acid (GABA(A)) receptor channels containing alpha1beta2gamma2-subunits were transiently expressed in HEK293 cells. Modulation by diazepam (DZ) was investigated using the patch-clamp technique with a device for ultra-fast solution exchange. GABA activated Cl(-)-currents were potentiated w...

journal_title：Neuroscience letters

authors： Krampfl K,Lepier A,Jahn K,Franke C,Bufler J

更新日期：1998-11-13 00:00:00

abstract：:There have been reports of regional differences in the activation of mitogen activated protein kinases (MAPKs) and in the induction of immediate early genes after electroconvulsive shock (ECS) in the rat brain. This study was performed to determine whether ECS induce the region-specific phosphorylation of MAPK-downstr...

journal_title：Neuroscience letters

authors： Ahn YM,Kang UG,Oh SW,Juhnn YS,Joo YH,Park JB,Kim YS

更新日期：2002-08-23 00:00:00

abstract：:The possible involvement of 2-amino-4-phosphonobutyrate (APB) recognition sites in mechanisms enabling the maintenance of long-term potentiation (LTP) was investigated in rat hippocampal slices. The action of D(-)- and L(+)-isomers of APB was tested on orthodromic EPSP and spike responses recorded extracellularly from...

journal_title：Neuroscience letters

authors： Reymann KG,Matthies H

更新日期：1989-03-27 00:00:00

abstract：:In order to analyze the elementary mechanisms underlying caffeine-induced epileptiform discharges, hippocampal slices of guinea pigs were exposed to this drug. When the bath concentration of caffeine exceeded 0.2 mM, periodically occurring paroxysmal depolarizations (PD) in CA3 neurons appeared. They were accompanied ...

journal_title：Neuroscience letters

authors： Moraidis I,Bingmann D,Lehmenkühler A,Speckmann EJ

更新日期：1991-08-05 00:00:00

abstract：:Four weeks after lesion of the cortico-striatal pathway, the specific kainic acid binding was reduced by 20% in the neostriatum. It is concluded that the binding sites are most likely not located on cortico-striatal neurons. The displacement of kainic acid by some chemical indicates that the kainic acid binding site i...

journal_title：Neuroscience letters

authors： Henke H,Cuénod M

更新日期：1979-03-01 00:00:00

abstract：:In an attempt to understand the changes of circulating neuropeptide Y (NPY) during hypoxia, the plasma level of NPY was investigated by radioimmunoassay. Exposure of rats to hypobaric hypoxia at an altitude of 18,000 ft for 4 weeks causes an increase of pulmonary pressure and an elevation of plasma NPY-like immunoreac...

journal_title：Neuroscience letters

authors： Cheng JT,Chen CF,Shum AY,Wang JY,Chen HI

更新日期：1992-06-22 00:00:00

abstract：:Nerve growth factor (NGF) was injected in the brain of neonatal rats. In eleven of thirty-one rats that received 1 microgram of mouse NGF (2.5S form) on postnatal day 3, NGF receptor-like immunoreactivity was found in the preoptic area (POA) and hypothalamus until 12 days after birth. However, no immunoreactivity was ...

journal_title：Neuroscience letters

authors： Nishizuka M,Arai Y

更新日期：1992-04-27 00:00:00

abstract：:We have examined the effect of ouabain, a Na,K-ATPase inhibitor known to secondarily increase intracellular Ca2+ levels, on evoked (phasic) transmitter release at the frog neuromuscular junction. As had been reported previously, we observed an increase in both spontaneous and evoked release with prolonged exposure to ...

journal_title：Neuroscience letters

authors： Mosier DR,Zengel JE

更新日期：1994-06-06 00:00:00

abstract：:Previous studies established that glutamate decarboxylase (GAD) is present in the brain of higher vertebrates in two forms composed of the homodimeric association of two subunits 59 and 63 kDa, respectively, that were found to be structurally related. We have performed quantitative comparative immunoblotting of whole ...

journal_title：Neuroscience letters

authors： Henry S,Tappaz M

更新日期：1991-10-14 00:00:00

abstract：:Carrageenan-induced inflammation of the rat hindpaw has been used as a model for persistent pain of inflammatory origin. The induction of inflammation resulting from carrageenan injection in the rat hindpaw has been shown to elicit an increase in the antinociceptive potency of morphine, an effect postulated to be rela...

journal_title：Neuroscience letters

authors： Ossipov MH,Kovelowski CJ,Porreca F

更新日期：1995-01-30 00:00:00

abstract：:To determine whether diabetes mellitus alters the lipid order and composition of cerebral microvessels, streptozotocin-induced diabetic rats were studied after 5 weeks of chronic hyperglycemia. Diabetes did not affect membrane order or the thermotropic transition temperature of cerebral microvessels as determined from...

journal_title：Neuroscience letters

authors： Mooradian AD,Smith TL

更新日期：1992-10-12 00:00:00

abstract：:The dopamine transporter (DAT1) gene has been implicated in the pathogenesis of many neuropsychiatric disorders, including schizophrenia. The present study aimed to investigate association of the DAT1 gene polymorphisms with schizophrenia in a Han Chinese population. Two single nucleotide polymorphisms (SNPs) in the D...

journal_title：Neuroscience letters

authors： Zheng C,Shen Y,Xu Q

更新日期：2012-04-04 00:00:00

abstract：:Using a specific radioimmunoassay (RIA), we have quantitated the hypothalamic and extrahypothalamic distribution of vasoactive intestinal polypeptide (VIP) in the rat brain. Highest concentrations of VIP were found in cerebral cortex, suprachiasmatic nucleus, and medial amygdaloid nucleus. Lower concentrations were fo...

journal_title：Neuroscience letters

authors： Samson WK,Said SI,McCann SM

更新日期：1979-05-01 00:00:00

abstract：:The phenotype of neurotrophin-3 (NT-3) null mutant mice is characterized by sensory ataxia and early postnatal death. Previous analysis revealed a severe depletion of peripheral sensory, sympathetic and parasympathetic neurons. Most of the deficits are established early during embryonic development. Whereas absence of...

journal_title：Neuroscience letters

authors： Barski JJ,Helbig C,Meyer M

更新日期：2011-09-01 00:00:00

abstract：:In order to study the mechanism of intracellular sorting and processing of the Alzheimer's disease amyloid precursor protein (APP), we deleted two potential N-linked glycosylation sites of APP by site-directed mutagenesis. Substitution of alanines for the critical asparagine residues Asn467 and Asn496 was performed. W...

journal_title：Neuroscience letters

authors： Yazaki M,Tagawa K,Maruyama K,Sorimachi H,Tsuchiya T,Ishiura S,Suzuki K

更新日期：1996-12-27 00:00:00

abstract：:Bradykinin, an inflammatory mediator produced from plasma kallikreins, has potent effects on vascular functions, including increasing plasma extravasation and vasodilation. Attenuation in the response (desensitization to maintained exposure or tachyphylaxis to repeated administration) to bradykinin actions on synovial...

journal_title：Neuroscience letters

authors： Miao FJ,Khasar SG,Green PG,Levine JD

更新日期：1996-04-19 00:00:00

abstract：:A tight coupling between lexico-semantic access and motor control has been established on the basis of neuropsychological, neurophysiological, and behavioral evidence. For example, sensory and motor cortices have been shown to be active when subjects listen to words denoting bodily actions. Kinematic analyses of subje...

journal_title：Neuroscience letters

authors： Shiller DM,Bourguignon N,Frak V,Nazir T,Cadoret G,Robert M,Lemay M

更新日期：2013-10-25 00:00:00

abstract：:Cortical depolarizations in the periphery of focal ischemia result in metabolic disturbances which contribute to the progression of the ischemic injury. In this experimental study, therefore, it was examined whether the duration of peri-infarct depolarizations, which reflects the severity of a metabolic mismatch, is d...

journal_title：Neuroscience letters

authors： Mies G

更新日期：1997-01-17 00:00:00