Partial rescue of NT-3 null mutant phenotype by a PDGF-β regulated transgene.

abstract：:Both feedforward and feedback mechanisms are used to ensure accurate movements. Feedback information comes primarily from vision and proprioception; the relative contributions of these modalities to on-line control of action and internal model maintenance remain unclear. We report data from an experiment in which a ch...

journal_title：Neuroscience letters

authors： Medina J,Jax SA,Coslett HB

更新日期：2009-02-27 00:00:00

abstract：:Synaptotagmin I (Syt I), a possible Ca(2+) sensor for neurotransmitter release, was suggested to be involved in neurite outgrowth of chick dorsal root ganglion (DRG) neurons, based on introduction of the antibody against the C2A domain into cells via mechanical lesions. Recently, however, the functional block antibody...

journal_title：Neuroscience letters

authors： Fukuda M,Mikoshiba K

更新日期：2000-12-01 00:00:00

abstract：:Converging evidence demonstrates an important role for gangliosides in brain function and neurodegenerative diseases. Exogenous GM1 is broadly neuroprotective, including in rodent, feline, and primate models of Parkinson's disease, and has shown positive effects in clinical trials. We and others have shown that inhibi...

journal_title：Neuroscience letters

authors： Dhanushkodi A,Xue Y,Roguski EE,Ding Y,Matta SG,Heck D,Fan GH,McDonald MP

更新日期：2019-01-23 00:00:00

abstract：:Evidence suggests that high peripheral beta-amyloid (Abeta)(1-40) levels and low ratios of Abeta(1-42)/Abeta(1-40) are associated with increased risk for Alzheimer's disease (AD). In this cross-sectional design, serum and plasma samples from 67 AD patients and 146 controls (similar in age and gender) were evaluated us...

journal_title：Neuroscience letters

authors： Abdullah L,Paris D,Luis C,Quadros A,Parrish J,Valdes L,Keegan AP,Mathura V,Crawford F,Mullan M

更新日期：2007-11-27 00:00:00

abstract：:Drug addiction is a process that transits from recreative and regular drug use into compulsive drug use. The two patterns of drug use, controlled drug intake and escalated drug intake, represent different stages in the development of drug addiction; and escalation of drug use is a hallmark of addiction. Accumulating s...

journal_title：Neuroscience letters

authors： Du HY,Cao DN,Chen Y,Wang L,Wu N,Li J

更新日期：2016-01-12 00:00:00

abstract：:Electrophysiological and anatomic studies suggest that the amygdala regulates gastrointestinal motility and gastric acid secretion via projections to the dorsal vagal complex. The topography of these projections is poorly understood. Here, these projections were investigated by injecting anterograde tracer, Phaseolus ...

journal_title：Neuroscience letters

authors： Liubashina O,Jolkkonen E,Pitkänen A

更新日期：2000-09-15 00:00:00

abstract：:The physiological role of mGluR1-induced inward current in a Purkinje neuron was studied in a cerebellar slice preparation. In a voltage-clamp condition, application of a mGluR1 agonist (RS)-3,5-dihydroxyphenylglycine (DHPG) induced both the transient and sustained phases of inward currents, which were blocked by simu...

journal_title：Neuroscience letters

authors： Yamakawa Y,Hirano T

更新日期：1999-12-24 00:00:00

abstract：:Current diagnosis of Major depressive disorder (MDD) depends on its clinical symptoms, not on the results of any laboratory examinations. Establishing biological markers for diagnosis of MDD is one of the most important problems to be solved in psychiatry practice. MDD patients (n=8) and a healthy control group (n=8) ...

journal_title：Neuroscience letters

authors： Wei K,Xue HL,Guan YH,Zuo CT,Ge JJ,Zhang HY,Liu BJ,Cao YX,Dong JC,Du YJ

更新日期：2016-08-26 00:00:00

abstract：:The study examined whether the generation of the forward propulsive force (PF) during gait initiation resulted mainly from the electromyogram activity of stance ankle plantar flexor muscles (APF) which 'push' on the ground as is generally claimed in the literature. Six unilateral above-knee amputees performed a specif...

journal_title：Neuroscience letters

authors： Michel V,Do MC

更新日期：2002-06-07 00:00:00

abstract：:The role of nitric oxide (NO) in N-methyl-D-aspartate (NMDA)-regulated release of 5-hydroxytryptamine (5-HT) in the frontal cortex and raphe nuclei of freely moving rats has been studied using microdialysis with dual probes, one in each region of the same animal. In order to do this the selective neuronal nitric oxide...

journal_title：Neuroscience letters

authors： Smith JC,Whitton PS

更新日期：2000-09-08 00:00:00

abstract：:The photoactivable compound phenylazide interacts reversibly with the frog's olfactory epithelium when delivered as an olfactory stimulus. Its application together with UV irradiation resulted in a differential reduction of the responses (electro-olfactogram) to several odorants. It was found that this chemical modifi...

journal_title：Neuroscience letters

authors： Delaleu JC,Holley A

更新日期：1983-06-30 00:00:00

abstract：:Using double-staining techniques, the distribution of NADPH-diaphorase (ND)- and nitric oxide synthase (NOS)-positive cells was compared in the periglomerular region of typical and atypical rat olfactory glomeruli. Dorsomedial and ventrolateral atypical glomeruli contained similar number of ND/NOS-positive periglomeru...

journal_title：Neuroscience letters

authors： Crespo C,Porteros A,Arévalo R,Briñón JG,Aijón J,Alonso JR

更新日期：1996-03-01 00:00:00

abstract：:We have previously shown that glycine binding sites on presynaptic NMDA receptors (NMDA-Rs) can tonically regulate glutamate release in the rat visual cortex. In the present study, we investigated the subunit composition of these presynaptic NMDA-Rs. We recorded miniature a-amino-3-hydroxy-5-methyl-4-isoxazolepropioni...

journal_title：Neuroscience letters

authors： Li YH,Han TZ,Meng K

更新日期：2008-02-27 00:00:00

abstract：:We investigated the relation between visual feedback and the degree of structure versus randomness in the variability of single-digit, isometric force output. Participants were instructed to maintain a constant level of force during the presence or absence of visual feedback about force output. The structure of force ...

journal_title：Neuroscience letters

authors： Athreya DN,Van Orden G,Riley MA

更新日期：2012-03-28 00:00:00

abstract：:Post-transcriptional control of gene expression by microRNAs provides an important regulatory system within neurons, allowing co-ordinate and fine-tuned expression of plasticity-related proteins. Indeed, specific microRNAs have been shown to be regulated by synaptic activity in the dentate gyrus, and contribute to the...

journal_title：Neuroscience letters

authors： Ryan B,Williams JM

更新日期：2019-08-10 00:00:00

abstract：:Conduction velocities of antidromically evoked impulses along the goldfish Mauthner axon were found to be inversely correlated with body length. To test the hypothesis that such a relation is accompanied by a reduction in axonal diameter with increasing fish size, Mauthner axon diameters were measured. A parabolic rel...

journal_title：Neuroscience letters

authors： Funch PG,Kinsman SL,Faber DS,Koenig E,Zottoli SJ

更新日期：1981-12-11 00:00:00

abstract：:Cholecystokinin (CCK) and leptin act coordinately in the brain to regulate food intake and energy balance. Recently we have reported that CCK enhances the permeability of brain barriers to leptin and we have proposed that CCK enhances energy expenditure in rats by activating in the hypothalamus the janus kinase/signal...

journal_title：Neuroscience letters

authors： Merino B,Somoza B,Ruiz-Gayo M,Cano V

更新日期：2008-09-12 00:00:00

abstract：:The intracellular stress-induced proteins provide protection against toxic insults. Here, a 60,000-Da heat shock 60 (hsp60)-like protein was detected, with five different antibodies, in conditioned media derived from rat cortical astrocytes and a human neuroblastoma cell line. Extracellular neuroblastoma hsp60-like im...

journal_title：Neuroscience letters

authors： Bassan M,Zamostiano R,Giladi E,Davidson A,Wollman Y,Pitman J,Hauser J,Brenneman DE,Gozes I

更新日期：1998-06-26 00:00:00

abstract：:When a tone-burst train with a short inter-burst interval is lateralized to the left and is followed by another tone-burst train lateralized to the right, listeners report a smooth shift of tone bursts along the intracranial axis from left to right (known as auditory saltation). When a sequence of tone bursts with a c...

journal_title：Neuroscience letters

authors： Kawabe T

更新日期：2010-01-14 00:00:00

abstract：:Using specific radioimmunoassays, melatonin was quantified in the aqueous humor and serum of male pigmented rabbits adapted to 12L:12D with lights on at 06.00 h. Melatonin concentrations in the aqueous humor at 08.00 and 16.00 h were similar (mean: 5.23 pg/ml) and significantly lower than those at 22.00 and 01.00 h (m...

journal_title：Neuroscience letters

authors： Yu HS,Yee RW,Howes KA,Reiter RJ

更新日期：1990-08-24 00:00:00

abstract：:Acetaldehyde (AcH) and salsolinol play important roles in the central effects of ethanol. This study aimed to investigate the effect of administration of AcH on dopamine (DA), DA-derived salsolinol and serotonin (5-HT) levels in the dorsal striatum of Aldh2-knockout (Aldh2-KO) and C57BL/6 N (WT) mice. Animals were tre...

journal_title：Neuroscience letters

authors： Ito A,Jamal M,Ameno K,Tanaka N,Takakura A,Kawamoto T,Kitagawa K,Nakayama K,Matsumoto A,Miki T,Kinoshita H

更新日期：2018-10-15 00:00:00

abstract：:Intracellular cyclic AMP regulation systems play an important role in the mechanisms of morphine dependence and withdrawal. In the present study, to clarify the involvement of phosphodiesterase (PDE) 4, degradation enzyme of cyclic AMP in morphine dependence and withdrawal we investigated the activities of PDE4 after ...

journal_title：Neuroscience letters

authors： Kimura M,Tokumura M,Itoh T,Inoue O,Abe K

更新日期：2006-08-14 00:00:00

abstract：:In the brain, the stress system plays an important role in motivating continued alcohol use and relapse. The neuropeptide substance P and the neurokinin-1 receptor (NK1R) are involved in the stress response and drug reward systems. Recent findings have shown that the binding of ligands to NK1Rs decreases the self-admi...

journal_title：Neuroscience letters

authors： Baek MN,Jung KH,Halder D,Choi MR,Lee BH,Lee BC,Jung MH,Choi IG,Chung MK,Oh DY,Chai YG

更新日期：2010-05-21 00:00:00

abstract：:In this report the effects of phencyclidine (PCP) on physiologic variables, local cerebral blood flow (LCBF), and on hippocampal cell damage were measured in a rat model of forebrain ischemia (2-vessel occlusion and hypotension). Ischemia was induced for 10 min. LCBF was determined after 2 min of recirculation, using ...

journal_title：Neuroscience letters

authors： Sauer D,Nuglisch J,Rossberg C,Mennel HD,Beck T,Bielenberg GW,Krieglstein J

更新日期：1988-09-12 00:00:00

abstract：:Field potentials were recorded with electrodes implanted in various cortical areas while a naive monkey was learning reaction time hand movements with complex tone. When cortical surface-negative, depth-positive potential (at a latency of about 80 ms after a stimulus onset) appeared in the rostral bank of the inferior...

journal_title：Neuroscience letters

authors： Gemba H,Miki N,Sasaki K

更新日期：1995-05-05 00:00:00

abstract：:Serum choline concentrations decrease during and after surgery. We undertook this study to determine whether the decrease of choline is associated with an increase in stress hormones. In 16 patients undergoing abdominal surgery with general anesthesia, circulating choline cortisol, prolactin, adrenocorticotropic hormo...

journal_title：Neuroscience letters

authors： Ozarda Ilçöl Y,Ozyurt G,Kilicturgay S,Uncu G,Ulus IH

更新日期：2002-05-10 00:00:00

abstract：:To study zinc (Zn) mobility in the rat olfactory tract, brain distribution of 65Zn after injection into the olfactory bulb or amygdaloid nuclei was analyzed by autoradiography. Twenty-four hours after 65Zn injection into the olfactory bulb, 65Zn was distributed in the ipsilateral piriform cortex, amygdaloid nuclei and...

journal_title：Neuroscience letters

authors： Takeda A,Ohnuma M,Sawashita J,Okada S

更新日期：1997-03-28 00:00:00

abstract：:Interleukin-1beta (IL1beta) and tumor necrosis factor-alpha (TNFalpha) are involved in several physiological functions regulated by brain. The current studies were performed to determine whether a diurnal rhythm of IL1beta and TNFalpha mRNAs, determined by real time RT-PCR, existed in specific brain regions linked to ...

journal_title：Neuroscience letters

authors： Cearley C,Churchill L,Krueger JM

更新日期：2003-11-27 00:00:00

abstract：:A comparative study was made of the enzyme choline acetyltransferase (ChAT) from normal and Alzheimer (senile dementia of the Alzheimer type) brain. The number of molecular weight and charge forms of the enzyme were determined in the caudate region of both brains. Efficient purification of active ChAT was achieved usi...

journal_title：Neuroscience letters

authors： Bruce G

更新日期：1985-08-30 00:00:00

abstract：:Spirulina maxima is a blue-green micro alga that contains abundant amounts of proteins (60-70%), vitamins, chlorophyll a, and C-phycocyanin (C-PC). It has been shown to reduce oxidative stress, and prevent diabetes and non-alcoholic fatty liver disease. However, it is unclear whether Spirulina maxima 70% ethanol extra...

journal_title：Neuroscience letters

authors： Koh EJ,Kim KJ,Choi J,Kang DH,Lee BY

更新日期：2018-04-23 00:00:00