Two-component models of reaching: evidence from deafferentation in a Fitts' law task.

Abstract:

:Both feedforward and feedback mechanisms are used to ensure accurate movements. Feedback information comes primarily from vision and proprioception; the relative contributions of these modalities to on-line control of action and internal model maintenance remain unclear. We report data from an experiment in which a chronically deafferented subject (JDY) and nine controls were asked to reach to targets of different sizes both with and without vision. Movement times of controls were consistent with Fitts' law on trials with and without vision. JDY's movement times were consistent with Fitts' law only with vision. She was inaccurate relative to controls with vision but exhibited a significantly greater decrement in performance than controls without vision. Finally, JDY's performance on trials with vision deteriorated as a function of the number of preceding trials on which vision was not available. These data provide support for classical models of motor control that divide reaching into an initial ballistic movement guided by efference copy, and a terminal stage where sensory feedback is crucial. Furthermore, these data also demonstrate that proprioception is needed to calibrate and maintain internal models of action.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Medina J,Jax SA,Coslett HB

doi

10.1016/j.neulet.2009.01.002

subject

Has Abstract

pub_date

2009-02-27 00:00:00

pages

222-6

issue

3

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(09)00012-3

journal_volume

451

pub_type

杂志文章
  • Autophosphorylated calcium/calmodulin-dependent protein kinase II alpha induced by cerebral ischemia immediately targets and phosphorylates N-methyl-D-aspartate receptor subunit 2B (NR2B) in hippocampus of rats.

    abstract::In this article, we investigated the autophosphorylation and translocation of calcium/calmodulin-dependent protein kinase II alpha (CaMKII alpha) in hippocampus during global ischemia. The following results were observed: (1) CaMKII alpha immediately became autophosphorylated after 3 min ischemia, at the same time, th...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(02)00961-8

    authors: Meng F,Zhang G

    更新日期:2002-11-15 00:00:00

  • Brain potentials indicate the effect of other observers' emotions on perceptions of facial attractiveness.

    abstract::Perceptions of facial attractiveness are sensitive to emotional expression of the perceived face. However, little is known about whether the emotional expression on the face of another observer of the perceived face may have an effect on perceptions of facial attractiveness. The present study used event-related potent...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2015.11.021

    authors: Huang Y,Pan X,Mo Y,Ma Q

    更新日期:2016-03-23 00:00:00

  • Intraocular colchicine selectively destroys immature ganglion cells in chicken retina.

    abstract::Low doses of colchicine (greater than 0.5 microgram) injected into the eyes of young chickens irreversibly inhibit axonal transport of material labelled with [3H]fucose. This is due to almost total destruction of the retinal ganglion cells, while other retinal cell types, including the displaced amacrine cells found i...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(81)90167-1

    authors: Morgan IG

    更新日期:1981-07-17 00:00:00

  • Dichotomizing unmyelinated afferents supplying pelvic viscera and perineum are rare in the sacral segments of the cat.

    abstract::We have tested the hypothesis that referred pain of pelvic viscera is elicited by dichotomizing branches of unmyelinated primary afferents projecting via the pelvic nerve to the viscera and through the pudendal nerve to the perineum where pelvic pain is commonly referred to. Using neurophysiological techniques 588 unm...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(88)90281-9

    authors: Häbler HJ,Jänig W,Koltzenburg M

    更新日期:1988-11-22 00:00:00

  • Effects of central administration of oxytocin-saporin cytotoxin on chronic inflammation and feeding/drinking behaviors in adjuvant arthritic rats.

    abstract::An increase in the arthritis index as a marker of chronic inflammation and suppression of food intake are observed in adjuvant arthritic (AA) rats. Our previous study demonstrated that central oxytocin (OXT)-ergic pathways were activated potently in AA rats. In the present study, OXT-saporin (SAP) cytotoxin, which che...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2016.04.010

    authors: Matsuura T,Kawasaki M,Hashimoto H,Yoshimura M,Motojima Y,Saito R,Ueno H,Maruyama T,Sabanai K,Mori T,Ohnishi H,Sakai A,Ueta Y

    更新日期:2016-05-16 00:00:00

  • Effects of aging on neuromagnetic mismatch responses to pitch changes.

    abstract::Although aging-related alterations in the auditory sensory memory and involuntary change discrimination have been widely studied, it remains controversial whether the mismatch negativity (MMN) or its magnetic counterpart (MMNm) is modulated by physiological aging. This study aimed to examine the effects of aging on mi...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2013.02.063

    authors: Cheng CH,Baillet S,Hsiao FJ,Lin YY

    更新日期:2013-06-07 00:00:00

  • Involvement of central cholinergic mechanisms on sodium intake induced by gabaergic activation of the lateral parabrachial nucleus.

    abstract::Bilateral injections of the GABA(A) agonist muscimol into the lateral parabrachial nucleus (LPBN) disrupt satiety and induce strong ingestion of water and 0.3M NaCl in fluid-replete rats by mechanisms not completely clear. In the present study, we investigated the effects of the blockade of central muscarinic choliner...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2012.11.042

    authors: Asnar DS,Roncari CF,De Luca LA Jr,de Paula PM,Colombari DS,Menani JV

    更新日期:2013-02-08 00:00:00

  • Ontogenesis of the axonal circuitry associated with the olfactory system of the rat embryo.

    abstract::The prenatal development of axonal connections in the rat olfactory system was studied using DiI. On day 16 (E16), the olfactory and vomeronasal nerves extended from the olfactory epithelia to the olfactory bulb (OB), the terminal nerve to the telencephalic septum, while axons of mitral and tufted cells reached the an...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(91)90482-9

    authors: Marchand R,Bélanger MC

    更新日期:1991-08-19 00:00:00

  • Coexistence of substance P and calcitonin gene-related peptide in the frog spinal cord.

    abstract::The localization of substance P (SP) and calcitonin gene-related peptide (CGRP) was studied in the untreated spinal cord of the frog using single or double immunohistochemical stainings. SP and CGRP appear to coexist in the primary afferent fibers and in the marginal and submarginal dorsal horn zones, as well as in th...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(87)90462-9

    authors: Venesio T,Mulatero B,Fasolo A

    更新日期:1987-10-05 00:00:00

  • The therapeutic potential of human umbilical cord blood-derived mesenchymal stem cells in Alzheimer's disease.

    abstract::The neuropathological hallmarks of Alzheimer's disease (AD) include the presence of extracellular amyloid-beta peptide (Abeta) in the form of amyloid plaques in the brain parenchyma and neuronal loss. The mechanism associated with neuronal death by amyloid plaques is unclear but oxidative stress and glial activation h...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2010.06.045

    authors: Lee HJ,Lee JK,Lee H,Shin JW,Carter JE,Sakamoto T,Jin HK,Bae JS

    更新日期:2010-08-30 00:00:00

  • Decreased cortical levels of astrocytic glutamate transport protein GLT-1 in a rat model of posttraumatic epilepsy.

    abstract::The extracellular homeostasis of glutamate in the brain is maintained by the efficient uptake into astroglial cells. The high extracellular glutamate levels seen during seizures are therefore probably a result of both an increased synaptic release and a deranged glutamate uptake. In this study we used immuno-blotting ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(00)01284-2

    authors: Samuelsson C,Kumlien E,Flink R,Lindholm D,Ronne-Engström E

    更新日期:2000-08-11 00:00:00

  • Removal of retinal input fails to elicit isthmo-tectal sprouting in the frog.

    abstract::The retina and nucleus isthmi both project in laminar fashion to the superficial layers of the frog's tectum. In order to determine whether isthmo-tectal axons show collateral sprouting after retinotectal input is removed, we injected [3H] proline into the nucleus isthmi and measured the volume of the crossed isthmo-t...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(81)90252-4

    authors: Udin SB,Gruberg ER

    更新日期:1981-12-11 00:00:00

  • Tetrodotoxin-resistant non-cholinergic neurogenic contraction evoked by capsaicinoids and piperine on the guinea-pig trachea.

    abstract::Contraction of the isolated tracheal strip to capsaicin was prevented by chronic denervation of the tissue. Tetrodotoxin, hyoscine and hexamethonium caused no inhibition of the response, suggesting that tetrodotoxin-resistant terminal portions of non-cholinergic nerves were activated in this way. There was a strong co...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(83)90426-3

    authors: Szolcsányi J

    更新日期:1983-11-21 00:00:00

  • Activation of calpain precedes morphological alterations during hydrogen peroxide-induced apoptosis in neuronally differentiated mouse embryonal carcinoma P19 cell line.

    abstract::In order to reveal neurodegeneration elicited by reactive oxygen intermediates (ROI), neuronally differentiated cells from mouse embryonal carcinoma P19 cell line were exposed to hydrogen peroxide (H2O2). Enhanced protein-phosphorylation on tyrosine residues was detectable within 5 min of exposure to H2O2, and gradual...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(99)00960-x

    authors: Ishihara I,Minami Y,Nishizaki T,Matsuoka T,Yamamura H

    更新日期:2000-01-28 00:00:00

  • Can vision compensate for a lower limbs muscular fatigue for controlling posture in humans?

    abstract::The purpose of the present experiment was to investigate the effect of vision on postural control following a lower limbs muscular fatigue. Ten adult males were asked to maintain a single leg upright posture as immobile as possible in two conditions of no-fatigue and fatigue of the calf muscles. This muscles fatigue w...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(01)01987-5

    authors: Vuillerme N,Nougier V,Prieur JM

    更新日期:2001-08-03 00:00:00

  • Somatostatin mRNA in the hippocampal formation following electroconvulsive shock in the rat.

    abstract::The effect of electroshock on the brain levels of somatostatin mRNA were evaluated by in situ hybridization using a selective oligonucleotide probe. Rats were submitted to single or repeated (7 days, one session for each day) sessions of electroshock. There was a marked increase of the expression of somatostatin mRNA ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(93)90321-b

    authors: Passarelli F,Orzi F

    更新日期:1993-04-30 00:00:00

  • Pressor, dipsogenic, natriuretic and kaliuretic response to central carbachol in rats with lesion of the medial septal area.

    abstract::In the present study we investigated the effect of electrolytic lesion of the medial septal area (MSA) on the dipsogenic, natriuretic, kaliuretic and pressor responses elicited by intracerebroventricular (i.c.v.) injection of the cholinergic agonist carbachol. Freely moving rats with sham or MSA lesion (1-7 days and 1...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(91)90300-i

    authors: Luiz AC,Saad WA,Camargo LA,Renzi A,De Luca Junior LA,Menani JV

    更新日期:1991-11-11 00:00:00

  • Renshaw cells are inactive during motor inhibition elicited by the pontine microinjection of carbachol.

    abstract::The present study was undertaken to determine whether the postsynaptic inhibition of motoneurons that occurs following the pontine microinjection of carbachol in the decerebrate cat is due to the activity of Renshaw cells. Thirty-two out of 37 Renshaw cells (86%) were spontaneously active prior to the administration o...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(88)90498-3

    authors: Morales FR,Engelhardt JK,Pereda AE,Yamuy J,Chase MH

    更新日期:1988-04-12 00:00:00

  • An efficient and non-enzymatic method for isolation and culture of endothelial cells from the nidus of human cerebral arteriovenous malformations.

    abstract::In this report, we describe an efficient and non-enzymatic method for isolating and culturing endothelial cells (ECs) from the nidus of surgically resected arteriovenous malformation (AVM) specimens. These cultured cells possessed typical phenotypic markers (i.e. von Willebrand factor and CD34), as well as morphologic...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2013.05.050

    authors: Zhang HF,Liang GB,Zhao MG,Song ZQ,Xu ZH

    更新日期:2013-08-26 00:00:00

  • Permissive effect of VIP on the hyperglycemic response induced by 2-deoxy-D-glucose.

    abstract::We previously obtained evidence that in rats the neurons in the suprachiasmatic nucleus (SCN) receiving retinal neural inputs may be involved in the regulation of glucose metabolism. In this study we examined whether the SCN neurons containing vasoactive intestinal peptide (VIP)-like immunoreactive substance (VIP neur...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(94)91103-7

    authors: Shimizu K,Hibino H,Komenami N,Nagai N,Nagai K,Nakagawa H

    更新日期:1994-07-04 00:00:00

  • Inspiratory neurons that are activated when inspiration is inhibited behaviorally.

    abstract::Respiration can be automatic or controlled behaviorally. Behavioral control in the cat occurs, at least in part, through control of the brainstem respiratory neurons that constitute the automatic system. Thus, when inspiration is inhibited behaviorally, inspiratory neurons in the medulla are inactivated. Reported here...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(87)90100-5

    authors: Orem J

    更新日期:1987-12-29 00:00:00

  • Expression of glycine and other amino acid receptors by rat spinal cord mRNA in Xenopus oocytes.

    abstract::Xenopus oocytes were injected with mRNA from adult or neonatal rat spinal cord, or from adult cerebral cortex, and examined electrophysiologically to measure currents elicited by various receptor agonists. The mRNAs induced the oocytes to acquire similar types of amino acid receptors, albeit with different potencies. ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(88)90668-4

    authors: Akagi H,Miledi R

    更新日期:1988-12-19 00:00:00

  • Regionally specific age-dependent decline in alpha 2-adrenoceptors: an autoradiographic study in human brain.

    abstract::The effect of sex, postmortem delay and aging on alpha 2-adrenoceptor binding was studied in tissue sections from several representative regions of the human brain from 21 subjects using [3H]UK-14304 as a ligand. Sex and postmortem delay did not influence the density of alpha 2-receptors. Aging resulted in clear decre...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(91)90588-k

    authors: Pascual J,del Arco C,González AM,Díaz A,del Olmo E,Pazos A

    更新日期:1991-12-09 00:00:00

  • Eye movement and postural sway in dyslexic children during sitting and standing.

    abstract::In this study, we investigated the eye movement and postural control performance in dyslexic children while reading text and performing Landolt reading when sitting and standing. Fifteen dyslexic and 15 non-dyslexic children were asked to sit in a chair while the eye movements were recorded, and were then asked to sta...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2018.08.042

    authors: Razuk M,Barela JA,Peyre H,Gerard CL,Bucci MP

    更新日期:2018-11-01 00:00:00

  • Lucifer yellow stains displaced amacrine cells of the chicken retina during embryonic development.

    abstract::We have used Lucifer Yellow for histological tracing of displaced amacrine cells within the ganglion cell layer (GCL) during the embryonic development of the chicken retina. Incubating whole eyes in the dye leads to bright staining of all displaced amacrine cells, whereas ganglion cells and glial cells are not stained...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(82)90099-4

    authors: Layer PG,Vollmer G

    更新日期:1982-08-16 00:00:00

  • Feedback about isometric force production yields more random variations.

    abstract::We investigated the relation between visual feedback and the degree of structure versus randomness in the variability of single-digit, isometric force output. Participants were instructed to maintain a constant level of force during the presence or absence of visual feedback about force output. The structure of force ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2012.02.002

    authors: Athreya DN,Van Orden G,Riley MA

    更新日期:2012-03-28 00:00:00

  • Ontogenesis of the pinealo-retinal neuronal connection in albino rats.

    abstract::It was accepted for a long time that in mammals there is only retinofugal neuronal connection between the eye and the pineal body (PB). In our previous paper we described that nerve cells were present in hamster PB and these neurons could establish a reverse connection with the retina through a transsynaptic pathway. ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2017.12.007

    authors: Csáki Á,Vereczki V,Lukáts Á,Boldogkői Z,Sebestyén A,Puskár Z,Köves K

    更新日期:2018-02-05 00:00:00

  • Field potential change in the prefrontal cortex of the left hemisphere during learning processes of reaction time hand movement with complex tone in the monkey.

    abstract::Field potentials were recorded with electrodes implanted in various cortical areas while a naive monkey was learning reaction time hand movements with complex tone. When cortical surface-negative, depth-positive potential (at a latency of about 80 ms after a stimulus onset) appeared in the rostral bank of the inferior...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(95)11509-u

    authors: Gemba H,Miki N,Sasaki K

    更新日期:1995-05-05 00:00:00

  • Alterations of prefrontal cortical microRNAs in methamphetamine self-administering rats: From controlled drug intake to escalated drug intake.

    abstract::Drug addiction is a process that transits from recreative and regular drug use into compulsive drug use. The two patterns of drug use, controlled drug intake and escalated drug intake, represent different stages in the development of drug addiction; and escalation of drug use is a hallmark of addiction. Accumulating s...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2015.11.016

    authors: Du HY,Cao DN,Chen Y,Wang L,Wu N,Li J

    更新日期:2016-01-12 00:00:00

  • Dysfunction of thermoregulation contributes to the generation of hyperthermia-induced seizures.

    abstract::Febrile seizures (FS) are generally defined as seizures taking place during fever. Long-term prognosis, including development of epilepsy and malformation of cognitive function, has been demonstrated after infantile FS. However, the mechanism that triggers seizures in hyperthermic environment is still unclear. We here...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2014.08.037

    authors: Feng B,Tang YS,Chen B,Dai YJ,Xu CL,Xu ZH,Zhang XN,Zhang SH,Hu WW,Chen Z

    更新日期:2014-10-03 00:00:00