Abstract:
:Interleukin-1beta (IL1beta) and tumor necrosis factor-alpha (TNFalpha) are involved in several physiological functions regulated by brain. The current studies were performed to determine whether a diurnal rhythm of IL1beta and TNFalpha mRNAs, determined by real time RT-PCR, existed in specific brain regions linked to the functions of these cytokines. Rats were sacrificed 2 h after light onset (AM) and 1 h prior to dark onset (PM). IL1beta mRNA levels in the AM were significantly higher than those obtained from rats sacrificed in the PM in the prefrontal cortex, parietal cortex, amygdala/piriform cortex, ventral hippocampus, hypothalamus, nucleus tractus solitarius, and nucleus accumbens, but not in the dorsal hippocampus. Time-of-day differences in TNFalpha mRNA levels were observed in all these brain regions. These results support the hypothesis that TNFalpha and IL1beta have physiological roles within the brain.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Cearley C,Churchill L,Krueger JMdoi
10.1016/j.neulet.2003.07.019keywords:
subject
Has Abstractpub_date
2003-11-27 00:00:00pages
61-3issue
1eissn
0304-3940issn
1872-7972pii
S0304394003009996journal_volume
352pub_type
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