Time of day differences in IL1beta and TNFalpha mRNA levels in specific regions of the rat brain.

Abstract:

:Interleukin-1beta (IL1beta) and tumor necrosis factor-alpha (TNFalpha) are involved in several physiological functions regulated by brain. The current studies were performed to determine whether a diurnal rhythm of IL1beta and TNFalpha mRNAs, determined by real time RT-PCR, existed in specific brain regions linked to the functions of these cytokines. Rats were sacrificed 2 h after light onset (AM) and 1 h prior to dark onset (PM). IL1beta mRNA levels in the AM were significantly higher than those obtained from rats sacrificed in the PM in the prefrontal cortex, parietal cortex, amygdala/piriform cortex, ventral hippocampus, hypothalamus, nucleus tractus solitarius, and nucleus accumbens, but not in the dorsal hippocampus. Time-of-day differences in TNFalpha mRNA levels were observed in all these brain regions. These results support the hypothesis that TNFalpha and IL1beta have physiological roles within the brain.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Cearley C,Churchill L,Krueger JM

doi

10.1016/j.neulet.2003.07.019

keywords:

subject

Has Abstract

pub_date

2003-11-27 00:00:00

pages

61-3

issue

1

eissn

0304-3940

issn

1872-7972

pii

S0304394003009996

journal_volume

352

pub_type

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