Abstract:
:In the brain, the stress system plays an important role in motivating continued alcohol use and relapse. The neuropeptide substance P and the neurokinin-1 receptor (NK1R) are involved in the stress response and drug reward systems. Recent findings have shown that the binding of ligands to NK1Rs decreases the self-administration of alcohol in mice. We examined the effect of an artificial microRNA (amiRNA) on the functional expression of NK1R in mouse brains. Lentiviruses expressing either an amiRNA targeting the NK1R (amiNK1R) or a negative control amiRNA (amiNC) were injected into mouse brains. Four weeks after amiRNA injection, we found that amiNK1R decreased the voluntary alcohol consumption compared to mice injected with amiNC. We also observed that NK1R expression was reduced in the hippocampus. RNA interference is an effective approach to regulate the expression of specific behavior-related genes. Our results support the potential use of amiRNA as a therapeutic agent for the treatment of alcohol dependence.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Baek MN,Jung KH,Halder D,Choi MR,Lee BH,Lee BC,Jung MH,Choi IG,Chung MK,Oh DY,Chai YGdoi
10.1016/j.neulet.2010.03.051subject
Has Abstractpub_date
2010-05-21 00:00:00pages
124-8issue
3eissn
0304-3940issn
1872-7972pii
S0304-3940(10)00348-4journal_volume
475pub_type
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