Abstract:
:Motoneuron death induced by sciatic nerve transection in neonatal rats has been related to induction of the neuronal isoform of nitric oxide synthase (nNOS), a diaphorase of which one of the cofactors is nicotinamide adenine dinucleotide phosphate (NADPH). We transected the sciatic nerve of neonatal rats (P2) and examined nNOS expression by immunostaining in neurons of the sciatic pool and of other spinal levels on the 5th day after surgery. No correspondence was observed between the surviving motoneurons and nNOS positive cells. The appearance and distribution of nNOS positive neurons at all spinal levels and laminae were similar to those of adult animals. These results are at variance with previous studies which showed correlation between motoneuron loss after axotomy and number of NADPH-diaphorase positive motoneurons after sciatic transection.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Rogério F,Teixeira SA,de Souza Queiroz L,De Nucci G,Langone Fdoi
10.1016/s0304-3940(01)01931-0keywords:
subject
Has Abstractpub_date
2001-07-13 00:00:00pages
61-4issue
2eissn
0304-3940issn
1872-7972pii
S0304-3940(01)01931-0journal_volume
307pub_type
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