A safer and more sensitive substitute for diamino-benzidine in the light microscopic demonstration of retrograde and anterograde axonal transport of HRP.

abstract：:The present study was undertaken to determine whether the postsynaptic inhibition of motoneurons that occurs following the pontine microinjection of carbachol in the decerebrate cat is due to the activity of Renshaw cells. Thirty-two out of 37 Renshaw cells (86%) were spontaneously active prior to the administration o...

journal_title：Neuroscience letters

authors： Morales FR,Engelhardt JK,Pereda AE,Yamuy J,Chase MH

更新日期：1988-04-12 00:00:00

abstract：:Seven single nucleotide polymorphisms (SNPs) present on 13q32 were detected among 124 British family trios consisting of fathers, mothers and affected offspring with schizophrenia. The transmission disequilibrium test (TDT) demonstrated that of these 7 SNPs, rs626716, a T to C base change at the KPNB3 locus, was the o...

journal_title：Neuroscience letters

authors： Wei J,Hemmings GP

更新日期：2004-09-30 00:00:00

abstract：:The efficiency of antisense approaches to produce a selective regional inhibition of the expression of brain 5-HT1A receptors was tested in the rat. In vivo ICV injections of modified antisense oligodesoxynucleotides yielded at most an 18% specific decrease in 5-HT1A receptor expression in the hippocampus only, as mea...

journal_title：Neuroscience letters

authors： Sari Y,Sibella C,Vergé D,Hamon M,Miquel MC

更新日期：1999-01-15 00:00:00

abstract：:Periostin has dual roles as a multifunctional cytokine and an extracellular matrix protein that binds to several integrins on a variety of cells. This study evaluated whether the expression and cellular localization of periostin changes in the spinal cord of mice with experimental autoimmune encephalomyelitis (EAE), a...

journal_title：Neuroscience letters

authors： Choi Y,Kim J,Ahn M,Shin T

更新日期：2020-01-10 00:00:00

abstract：:Neurotrophic factors maintain and modulate neuron function in adults. We tested the hypothesis that neurotrophic factors rapidly alter intracellular calcium concentrations, thereby affecting neuron excitability. The majority of rat nodose neurons express TrkA, TrkB and TrkC receptor after 1 day in culture. Addition of...

journal_title：Neuroscience letters

authors： Lamb K,Bielefeldt K

更新日期：2003-01-09 00:00:00

abstract：:In a random number generation (RNG) task subjects are instructed to generate the numbers 1-10 in a random fashion. RNG performance is assumed to involve executive functions, as it requires controlled response generation and suppression of habitual responses. To investigate cerebral structures involved in RNG associate...

journal_title：Neuroscience letters

authors： Daniels C,Witt K,Wolff S,Jansen O,Deuschl G

更新日期：2003-07-10 00:00:00

abstract：:The effects of Ga-Al-As diode laser (830 nm, 16.2 mW) irradiation on the distal portion of the processes of cultured murine dorsal root ganglion (DRG) neurons associated with C-fibers were studied by patch-clamp whole-cell recording of membrane potentials at the cell body. The chemical as well as laser light stimulati...

journal_title：Neuroscience letters

authors： Jimbo K,Noda K,Suzuki K,Yoda K

更新日期：1998-01-09 00:00:00

abstract：:Upregulation of cyclin-dependent kinase 5 (Cdk5) after chronic cocaine administration has led to speculation that Cdk5 plays an important role in drug addiction. However, as Cdk5 involvement is implicated in a variety of neural events, including neuronal development, synaptic plasticity and learning, a specific role i...

journal_title：Neuroscience letters

authors： Seiwell AP,Reveron ME,Duvauchelle CL

更新日期：2007-04-24 00:00:00

abstract：:Ibotenate and trans-D,L-1-amino-1,3-cyclopentanedicarboxylic acid (trans-ACPD) are rigid analogues of glutamate. Ibotenate has been shown to activate phosphoinositide hydrolysis in rat brain slices. We now report that trans-ACPD also stimulates phosphoinositide hydrolysis but with much higher potency and efficacy than...

journal_title：Neuroscience letters

authors： Desai MA,Conn PJ

更新日期：1990-02-05 00:00:00

abstract：:Rat dorsal root ganglion neurons can be classified into at least three distinct groups based on cell size, afferent fiber diameter, electrophysiological properties, sensitivity to vanilloid agonists such as capsaicin, and function. In the present study, ATP-activated current in these neurons was characterized using wh...

journal_title：Neuroscience letters

authors： Li C,Peoples RW,Lanthorn TH,Li ZW,Weight FF

更新日期：1999-03-19 00:00:00

abstract：:Glucose uptake is increased during motoneuron regeneration. Since this glucose is probably used as an energy source for axonal regeneration we postulated that hypoglycemia might interfere with motoneuron regeneration. In order to partially test this hypothesis we attempted to induce moderate hypoglycemia by fasting ra...

journal_title：Neuroscience letters

authors： Singer PA,Mehler S

更新日期：1983-10-31 00:00:00

abstract：:Alzheimer disease (AD) is the most common type of dementia, and is currently incurable. The efficacy of existing treatments for AD such as acetylcholinesterase inhibitors is limited to symptom improvement. Research on disease-modifying therapies (DMTs) has conventionally focused on amelioration of CNS pathogenesis. Tw...

journal_title：Neuroscience letters

authors： Shozawa H,Oguchi T,Tsuji M,Yano S,Kiuchi Y,Ono K

更新日期：2018-06-11 00:00:00

abstract：:The aim of the present experiment was to study how hypnotic susceptibility and hypnosis affect motoneuron excitability. In a first trial, human subjects were selected according to their hypnotic susceptibility. In a second trial, the Hoffmann (H) reflex amplitude of the soleus muscle was studied in 3 groups: (1) highl...

journal_title：Neuroscience letters

authors： Santarcangelo EL,Busse K,Carli G

更新日期：1989-09-25 00:00:00

abstract：:We determined the effect of naloxone and morphine on the differentiation of pheochromocytoma cell, the PC12 cells, induced by nerve growth factor (NGF). PC12 cells were grown in medium containing NGF with or without the addition of naloxone or morphine for up to 10-day treatments. NGF-induced morphological differentia...

journal_title：Neuroscience letters

authors： Yeh GC,Hsieh TH,Chang SF

更新日期：1998-08-07 00:00:00

abstract：:Electroencephalography (EEG) is a non-invasive technique for monitoring electrical activity and has good time resolution. Combining these advantages of EEG with dipole-tracing analysis incorporating a realistic three-layer head model (scalp-skull-brain head model; SSB/DT) allows for the detection of dipoles in the mil...

journal_title：Neuroscience letters

authors： Inoue M,Masaoka Y,Kawamura M,Okamoto Y,Homma I

更新日期：2008-05-30 00:00:00

abstract：:The level of endogenous nerve growth factor (NGF) in rat sciatic nerve was determined using a highly sensitive two-site enzyme immunoassay. After crushing this nerve NGF accumulated linearly distal to the crush during the first 12 h to reach levels 13-fold higher than in the uncrushed contralateral side. In contrast, ...

journal_title：Neuroscience letters

authors： Korsching S,Thoenen H

更新日期：1983-08-19 00:00:00

abstract：:After producing a model of subarachnoid hemorrhage (SAH) by a single injection of fresh autologous arterial blood into the cisterna magna in the dog, we immunohistochemically examined changes of calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) in perivascular nerve fibers in the large pial arteries by u...

journal_title：Neuroscience letters

authors： Nozaki K,Kikuchi H,Mizuno N

更新日期：1989-07-17 00:00:00

abstract：:Exposure of rat hippocampal neurons to the peptide amyloid beta (A beta) (25-35) as well as A beta (1-40) peptides enhances phosphorylation of tau to a paired helical filament (PHF)-state through activation of tau protein kinase I (TPK I)/glycogen synthase kinase-3 beta (GSK-3 beta) [Busciglio, J., Lorenzo, A., Yeh, J...

journal_title：Neuroscience letters

authors： Takashima A,Noguchi K,Michel G,Mercken M,Hoshi M,Ishiguro K,Imahori K

更新日期：1996-01-12 00:00:00

abstract：:We assessed, by quantitative autoradiography, the density of high-affinity alpha 2-adrenoceptors in hippocampus and frontal cortex sections from 18 patients dying with Alzheimer's disease (AD) in comparison with a control group of 13 matched cases. The full agonist [3H]bromoxidine (UK-14304) was used as a ligand. In A...

journal_title：Neuroscience letters

authors： Pascual J,Grijalba B,García-Sevilla JA,Zarranz JJ,Pazos A

更新日期：1992-08-03 00:00:00

abstract：:The morphology of single saccular afferents was studied by the intracellular horseradish peroxidase (HRP) method. Four neurons were sufficiently stained to allow reconstruction of their axonal arborizations. The main axon of these neurons bifurcated into an ascending and a descending branch at the level of the lateral...

journal_title：Neuroscience letters

authors： Imagawa M,Graf W,Sato H,Suwa H,Isu N,Izumi R,Uchino Y

更新日期：1998-01-16 00:00:00

abstract：:Mechanosensitivity is a crucial but poorly understood property of the sensory nervous system. Transient receptor potential (TRP) channels, which have been found to be responsible for the detection of other sensory stimuli such as temperature and pungent chemicals, have been suggested to also recognize stretch or press...

journal_title：Neuroscience letters

authors： Staaf S,Maxvall I,Lind U,Husmark J,Mattsson JP,Ernfors P,Pierrou S

更新日期：2009-06-19 00:00:00

abstract：:Unilateral transtympanic administration of the sodium channel blocker tetrodotoxin (75 microl of 3 mM TTX in 0.1 M citrate buffer, pH 5.0) produced behavioral symptoms indicative of unilateral vestibular disruption. Following survival times of 2 and 24 h immunocytochemistry for Fos revealed asymmetric labeling in the ...

journal_title：Neuroscience letters

authors： Saxon DW

更新日期：2003-03-13 00:00:00

abstract：:The blood-brain barrier (BBB) maintains the homeostasis between the central nervous system and the blood circulation. One of the main efflux transporter proteins at the BBB is P-glycoprotein (P-gP) also known as ABCB1 or MDR1. Due to the important role of P-gP for the transport barrier function of the BBB, the presenc...

journal_title：Neuroscience letters

authors： Neuhaus W,Stessl M,Strizsik E,Bennani-Baiti B,Wirth M,Toegel S,Modha M,Winkler J,Gabor F,Viernstein H,Noe CR

更新日期：2010-01-22 00:00:00

abstract：:We have tested the hypothesis that referred pain of pelvic viscera is elicited by dichotomizing branches of unmyelinated primary afferents projecting via the pelvic nerve to the viscera and through the pudendal nerve to the perineum where pelvic pain is commonly referred to. Using neurophysiological techniques 588 unm...

journal_title：Neuroscience letters

authors： Häbler HJ,Jänig W,Koltzenburg M

更新日期：1988-11-22 00:00:00

abstract：:Freshly dissected chick neural retina and pigmented epithelium do not apparently contain asymmetric molecular forms (A-forms) of acetylcholinesterase (AChE). The neighboring choroid, and the ciliary muscles and iris, are however rich in type II A-forms (high salt/EDTA-extractable). Most if not all the asymmetric AChE ...

journal_title：Neuroscience letters

authors： Barat A,Ramos M,Prada C,Ramírez G

更新日期：1990-05-04 00:00:00

abstract：:Lumbar spinal cord explants, harvested from neonatal rat pups aged between postnatal day 0 (P0) and P7, were cultured for a period of 48 h in the chemically defined medium R(12) [17] (Romijn, H.J., van-Huijen, F., Wolters, P.S., Neurosci Biobehav Rev, 8 (1984) 301-334), embedded in a collagen matrix. The outgrowth int...

journal_title：Neuroscience letters

authors： Mouveroux JM,Lakke EA,Marani E

更新日期：2001-09-28 00:00:00

abstract：:The effect of the metabotropic glutamate receptor (mGluR) antagonist (RS)-alpha-methyl-4-carboxyphenylglycine (MCPG) was investigated on the induction of long-term potentiation (LTP) of alpha-amino-3-hydroxy-5- methyl-4-isoxazoleproprionate receptor-mediated excitatory postsynaptic currents (epscs) recorded from denta...

journal_title：Neuroscience letters

authors： Wang Y,Rowan MJ,Anwyl R

更新日期：1995-09-15 00:00:00

abstract：:The effects of aging on the stress response of the septo-hippocampal cholinergic neurons was assessed by monitoring hippocampal acetylcholine (ACh) release. Young (3-4 month old) and aged (23-24 month old) male rats were subjected to restraint stress for 1 h. ACh was elevated within 15 min of the onset of restraint st...

journal_title：Neuroscience letters

authors： Mizuno T,Kimura F

更新日期：1997-01-24 00:00:00

abstract：:Our aim was to investigate the neuromodulatory role of diadenosine tetraphosphate (Ap(4)A). Ap(4)A-binding sites were detected in striatum and hippocampus membranes using [(35)S]-ADP beta S as radioligand and Ap(4)A and epsilon-(Ap(4)A), di-ethenoadenosine tetraphosphate, as displacers. Effects of epsilon-(Ap(4)A) on ...

journal_title：Neuroscience letters

authors： Oaknin S,Rodríguez-Ferrer CR,Aguilar JS,Ramos A,Rotllán P

更新日期：2001-08-31 00:00:00

abstract：:Pitrazepin is a potent new GABA antagonist which differs from bicuculline in its chemical structure and its interaction with both [3H]muscimol and [3H]flunitrazepam binding sites, whereby the potency of pitrazepin in displacing [3H]muscimol exceeds that of bicuculline by at least a factor of 10. In physiological exper...

journal_title：Neuroscience letters

authors： Gähwiler BH,Maurer R,Wüthrich HJ

更新日期：1984-04-06 00:00:00