(RS)-alpha-Methyl-4-carboxyphenylglycine inhibits long-term potentiation only following the application of low frequency stimulation in the rat dentate gyrus in vitro.

Abstract:

:The effect of the metabotropic glutamate receptor (mGluR) antagonist (RS)-alpha-methyl-4-carboxyphenylglycine (MCPG) was investigated on the induction of long-term potentiation (LTP) of alpha-amino-3-hydroxy-5- methyl-4-isoxazoleproprionate receptor-mediated excitatory postsynaptic currents (epscs) recorded from dentate granule cells in response to presynaptic stimulation of the associational/commissural pathway of the rat dentate gyrus in vitro. MCPG (500 microM, 60 min) did not inhibit the induction of LTP of epscs induced by high frequency stimulation (HFS) at sites which had received only test stimulation (0.05/s) preceding the HFS. MCPG did, however, block the induction of LTP of epscs elicited by HFS if the HFS was preceded by the induction of long-term depression elicited by low frequency stimulation (5 Hz for 3 min). After such low frequency stimulation, HFS induced only a short-term potentiation lasting up to a maximum of 10 min in the presence of MCPG.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Wang Y,Rowan MJ,Anwyl R

doi

10.1016/0304-3940(95)11937-r

subject

Has Abstract

pub_date

1995-09-15 00:00:00

pages

207-10

issue

3

eissn

0304-3940

issn

1872-7972

pii

030439409511937R

journal_volume

197

pub_type

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