Lumbar spinal cord explants from neonatal rat display age-related decrease of outgrowth in culture.

abstract：:Mutations in APP are associated with familial early-onset Alzheimer disease (FAD). Examination of the genomic sequence in one patient with FAD revealed a change located in the axon 17 of the APP gene at position 275329G>A (GenBank accession number: D87675; GI: 2429080); cDNA sequence 2137G>A (GenBank accession number:...

journal_title：Neuroscience letters

authors： Armstrong J,Boada M,Rey MJ,Vidal N,Ferrer I

更新日期：2004-11-11 00:00:00

abstract：:Stroke in rodents is associated with increased neurogenesis and the migration of newborn neurons to sites of brain ischemia, where they may participate in repair and recovery. To determine if neurogenesis following stroke yields functional new neurons, we labeled neuronal precursors in the mouse subventricular zone (S...

journal_title：Neuroscience letters

authors： Lai B,Mao XO,Xie L,Jin K,Greenberg DA

更新日期：2008-09-19 00:00:00

abstract：:It has been hypothesized that auditory temporal processing plays a major role in the aetiology of dyslexia. Event-related brain potentials (mismatch negativity, MMN) of auditory temporal processing were assessed in 15 dyslectic adults and 20 controls. A complex tonal pattern was used where the difference between stand...

journal_title：Neuroscience letters

authors： Schulte-Körne G,Deimel W,Bartling J,Remschmidt H

更新日期：1999-11-26 00:00:00

abstract：:During the early postnatal development of the rat, gamma-aminobutyric acid (GABA)-like immunoreactive axons were contained within the subcortical white matter. Some of the immunoreactive axons crossed the midline, while others followed a vertical or longitudinal trajectory within the lateral part of the corpus callosu...

journal_title：Neuroscience letters

authors： Cobas A,Alvarez-Bolado G,Fairén A

更新日期：1988-10-31 00:00:00

abstract：:A two pulse technique was used to study the decay of mechanical activation in TTX poisoned mouse extensor digitorum longus (EDL) and soleus muscle fibres. A two microelectrode point voltage clamp technique was used with visual endpoint determination of the threshold potential for activation. The excitatory effect of a...

journal_title：Neuroscience letters

authors： Dulhunty AF

更新日期：1979-10-01 00:00:00

abstract：:We investigated whether the perceived roughness of the end of a tool is influenced by the texture of the handle used to hold it. Participants rated the roughness of the ends (caps) of a series of tools by rubbing them along their forearm, and indicated the perceived roughness of the tool's cap by means of an anchored ...

journal_title：Neuroscience letters

authors： Zampini M,Mawhinney S,Spence C

更新日期：2006-06-12 00:00:00

abstract：:To investigate the working mechanism of the conflict processing system, pairs of colored numbers were sequentially presented on a screen to subjects. They were asked to determine if the magnitude or the color of the two numbers was identical. Event-related potentials (ERPs) were recorded at the same time. A negative p...

journal_title：Neuroscience letters

authors： Wang H,Wang Y,Kong J,Cui L,Tian S

更新日期：2001-02-09 00:00:00

abstract：:There is evidence indicating that the brain's dopaminergic system is involved in age-associated memory impairment. However, specific roles in this process for the different dopamine receptor subtypes have not been elucidated. The cAMP-response element binding protein (CREB) is one of the cellular molecules that have b...

journal_title：Neuroscience letters

authors： Xing B,Meng X,Wei S,Li S

更新日期：2010-09-13 00:00:00

abstract：:Reactive oxygen species and inflammatory signaling have been identified as pivotal pathophysiological factors contributing to epileptogenesis. Considering the development of combined anti-inflammatory and antioxidant treatment strategies with antiepileptogenic potential, a characterization of the time course of microg...

journal_title：Neuroscience letters

authors： Rettenbeck ML,von Rüden EL,Bienas S,Carlson R,Stein VM,Tipold A,Potschka H

更新日期：2015-07-10 00:00:00

abstract：:Inattention and impulsivity are the two most important indices for evaluations of ADHD. Currently, inattention and impulsivity were evaluated by clinical scales. The intelligent evaluation of the two indices using machine learning remains largely unexplored. This paper aimed to build regression modes for inattention a...

journal_title：Neuroscience letters

authors： Wang XH,Xu J,Li L

更新日期：2020-04-17 00:00:00

abstract：:Noise-induced hearing loss (NIHL) severely impacts the quality of life of affected individuals. Oxidative stress resulting from noise exposure is a significant cause of NIHL. Although histone deacetylase (HDAC) inhibitors were shown to protect against NIHL, the underlying mechanism remains unclear, and it is not known...

journal_title：Neuroscience letters

authors： Yang DH,Xie J,Liu K,Peng Z,Guo JY,Yu SK,Wang GP,Gong SS

更新日期：2017-11-01 00:00:00

abstract：:NCB-20 cells expressed m1- and m4-muscarinic acetylcholine receptor (mAChR) mRNAs, while NG108-15 cells expressed only m4-mAChR mRNA. Butyrate induced a time-dependent increase in the level of m1-mAChR mRNA with no change in the m4-mAChR mRNA level in NCB-20 cells. Similarly, butyrate did not affect the m4-mAChR mRNA ...

journal_title：Neuroscience letters

authors： Fukamauchi F,Mataga N,Wang YJ,Chuang DM

更新日期：1996-07-05 00:00:00

abstract：:Nerve cells were isolated from dorsal root ganglia of senescent mouse (C57 black, male) by collagenase and were grown on collagen-coated plastic dishes. The nerve cells extended their neurites and survived for more than 3 weeks in vitro. Intracellular recording with a glass microelectrode revealed that, although their...

journal_title：Neuroscience letters

authors： Fukuda J,Yamaguchi K

更新日期：1981-11-04 00:00:00

abstract：:In this study the effect of exogenous oxytocin and of massage-like stroking on the withdrawal latency responses to heat and mechanical nociceptive stimulation were investigated in rats. A hot-plate test and the Randall-Selitto test were used to assess the withdrawal responses. Exogenous oxytocin (0.1-1 mg/kg) and stro...

journal_title：Neuroscience letters

authors： Agren G,Lundeberg T,Uvnäs-Moberg K,Sato A

更新日期：1995-02-24 00:00:00

abstract：:Pannexins form single membrane channels that regulate the passage of ions, small molecules and metabolites between the intra- and extracellular compartments. In the central nervous system, these channels are integrated into numerous signaling cascades that shape brain physiology and pathology. Post-translational modif...

journal_title：Neuroscience letters

authors： Lohman AW,Weilinger NL,Santos SM,Bialecki J,Werner AC,Anderson CL,Thompson RJ

更新日期：2019-03-16 00:00:00

abstract：:Cholinergic projections originating in the basal forebrain (BF) play important roles in the heterosynaptic facilitation of synaptic strength in various sensory cortices, including the primary visual cortex (V1). Here, using urethane-anesthetized rats, we find that pairing burst stimulation of the BF with single pulse ...

journal_title：Neuroscience letters

authors： Gagolewicz PJ,Dringenberg HC

更新日期：2009-10-02 00:00:00

abstract：:Cerebellar granule neurons can be maintained in culture in a medium containing high serum and depolarising levels of KCl. When serum is removed and the KCl levels lowered from 25 to 5 mM, the cells undergo apoptosis. Apoptosis can be prevented by inhibitors of transcription or translation, suggesting a need for macrom...

journal_title：Neuroscience letters

authors： Ginham R,Harrison DC,Facci L,Skaper S,Philpott KL

更新日期：2001-04-20 00:00:00

abstract：:Diabetic polyneuropathy is a common and disturbing complication of diabetes mellitus, presenting patients and caregivers with a substantial disease burden. Emerging mechanisms which are underlying diabetes may provide novel pathways to understand diabetic polyneuropathy (DPN). Specifically, non-coding RNA molecules co...

journal_title：Neuroscience letters

authors： Meydan C,Üçeyler N,Soreq H

更新日期：2020-07-13 00:00:00

abstract：:The neurotoxicity of the glutamate receptor agonists N-methyl-D-aspartate (NMDA), (+/-)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA), and kainate was quantitatively assessed in murine spinal cord and cortical cultures prepared under identical conditions. Compared with cortical neurons, spinal neuron...

journal_title：Neuroscience letters

authors： Regan RF

更新日期：1996-07-26 00:00:00

abstract：:In the rat, unilateral dorsal cervicothoracic rhizotomy (C5-T2) resulted in autotomy of the ipsilateral limb. The onset of self-mutilation was variable and attained the maximum degree 8-9 weeks after the dorsal root section. Fifteen and 60 days after the lesion the monoamines dopamine (DA), noradrenaline (NA) and sero...

journal_title：Neuroscience letters

authors： Colado MI,Arnedo A,Peralta E,Del Río J

更新日期：1988-05-03 00:00:00

abstract：:We describe a novel aspect of action of memantine ex vivo, in the brain cortical slices and in vitro, in mixed glial cultures. The drug potently increased the production of kynurenic acid, an endogenous tryptophan metabolite blocking N-methyl-D-aspartate (NMDA) and nicotinic alpha7 receptors. In cortical slices memant...

journal_title：Neuroscience letters

authors： Kloc R,Luchowska E,Wielosz M,Owe-Larsson B,Urbanska EM

更新日期：2008-04-18 00:00:00

abstract：:The distribution of gamma-aminobutyric acid (GABA)-like immunoreactivity was studied in semithin sections through the inferior olivary complex in two baboon species. About 5% of the olivary neurons were GABA-immunoreactive. The GABA-immunoreactive neurons differed from the large majority of olivary neurons by their sm...

journal_title：Neuroscience letters

authors： Walberg F,Ottersen OP

更新日期：1989-06-19 00:00:00

abstract：:The aim of the study was to investigate whether repetitive/temporal hypoxia up-regulated P-glycoprotein (P-gp) in cultured rat brain microvascular endothelial cells (rBMECs). Cultured rBMECs were used as in vitro blood brain barrier (BBB) model. Cells reached confluence were subjected to temporal hypoxic exposure. Und...

journal_title：Neuroscience letters

authors： Xiao-Dong L,Zhi-Hong Y,Hui-Wen Y

更新日期：2008-02-27 00:00:00

abstract：:Considerable evidence suggests that low (picomolar) concentrations of the HIV-1 envelope glycoprotein gp120 induce neuronal cell death by stimulating the release of microglial toxins, which in turn activate N-methyl-D-aspartate (NMDA) receptors. Conversely, high (micromolar) concentrations of gp120 have been reported ...

journal_title：Neuroscience letters

authors： Wittekindt B,Betz H,Laube B

更新日期：2000-02-18 00:00:00

abstract：:Eight young males were subjected to a single blind cross-over test to see the effects of vitamin B12 (methylcobalamin; VB12) on the phase-response of the circadian melatonin rhythm to a single bright light exposure. VB12 (0.5 mg/day) or vehicle was injected intravenously at 1230 h for 11 days, which was followed by or...

journal_title：Neuroscience letters

authors： Hashimoto S,Kohsaka M,Morita N,Fukuda N,Honma S,Honma K

更新日期：1996-12-13 00:00:00

abstract：:The cloned vanilloid receptor-1 (VR1) is recognized as a common molecular target for protons, noxious heat, and vanilloids. The presence of VR1 in the dorsal root, trigeminal, and nodose ganglia has been firmly established, but it is unclear in the gut, despite this VR1 may be important for gastric mucosal homeostasis...

journal_title：Neuroscience letters

authors： Nozawa Y,Nishihara K,Yamamoto A,Nakano M,Ajioka H,Matsuura N

更新日期：2001-08-17 00:00:00

abstract：:Monoclonal antibodies against ryanodine receptor (5C3) and calcium ATPase (D12) of skeletal muscle sarcoplasmic reticulum were used in an immunoelectron microscopic study of cerebellar Purkinje cells and neurons of the hypoglossal and dorsal motor nuclei of the vagus (DMV) from rat and guinea-pig. All neurones were la...

journal_title：Neuroscience letters

authors： Sah P,Dulhunty A,Junankar P,Stanhope C

更新日期：1994-01-31 00:00:00

abstract：:Ovariectomy in the rat abolishes alpha-bungarotoxin (alpha-BTX) binding within the suprachiasmatic nucleus (SCN), a putative circadian pacemaker, and markedly reduces cholinergic activation of SCN cells. Circadian rhythms of running wheel activity were monitored continuously in intact male and female and chronically o...

journal_title：Neuroscience letters

authors： Mistlberger RE,Rusak B

更新日期：1986-12-23 00:00:00

abstract：:Glioblastoma is the most common astrocytic brain tumor in humans. Current therapies for this malignancy are mostly ineffective. Photodynamic therapy (PDT), an exciting treatment strategy based on activation of a photosensitizer, has not yet been extensively explored for treating glioblastoma. We used 5-aminolevulinic ...

journal_title：Neuroscience letters

authors： Karmakar S,Banik NL,Patel SJ,Ray SK

更新日期：2007-03-30 00:00:00

abstract：:The present study was designed to investigate the role of the interaction of pentobarbital with gamma-aminobutyric acid (GABA)ergic drugs acting on the Cl(-)-adenosine triphosphate (ATP)ase activity of the plasma membranes fraction of bream brain. The preincubation and then incubation of the membranes with pentobarbit...

journal_title：Neuroscience letters

authors： Menzikov S,Menzikova O

更新日期：2002-12-16 00:00:00