Abstract:
:Eight young males were subjected to a single blind cross-over test to see the effects of vitamin B12 (methylcobalamin; VB12) on the phase-response of the circadian melatonin rhythm to a single bright light exposure. VB12 (0.5 mg/day) or vehicle was injected intravenously at 1230 h for 11 days, which was followed by oral administration (2 mg x 3/day) for 7 days. A serial blood sampling was performed under dim light condition (less than 200 lx) and plasma melatonin rhythm was determined before and after a single bright light exposure (2500 lx for 3 h) at 0700 h. The melatonin rhythm before the light exposure showed a smaller amplitude in the VB12 trial than in the placebo. The light exposure phase-advanced the melatonin rhythm significantly in the VB12 trail, but not in the placebo. These findings indicate that VB12 enhances the light-induced phase-shift in the human circadian rhythm.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Hashimoto S,Kohsaka M,Morita N,Fukuda N,Honma S,Honma Kdoi
10.1016/s0304-3940(96)13247-xsubject
Has Abstractpub_date
1996-12-13 00:00:00pages
129-32issue
2eissn
0304-3940issn
1872-7972pii
S030439409613247Xjournal_volume
220pub_type
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