Abstract：
:It is generally assumed that the majority of substance P (SP)-containing afferents are also immunoreactive for calcitonin gene-related peptide (CGRP). In order to determine whether this is also the case in articular afferents where the contents of these peptides are low, we carried out a double labeling study using Fast Blue (FB) as a retrograde tracer injected into the center of the knee joint cavity of the dog together with immunohistochemistry for SP and CGRP. After 7-36 days of survival, dorsal root ganglia (DRGs, L4-S1) were removed. Labeled cells were found mainly (94%) in L5 - 6 DRGs, and SP- and CGRP-like immunoreactivity was found in about 17 and 29% of FB-labeled cells, respectively. The coexistence of SP and CGRP was observed in 10.4% of articular afferents and only 62.7% of SP-positive articular neurons contained CGRP, a much lower ratio than in other afferents of the dog such as testicular afferents. Our data suggest that these peptides are not always released together and that they do not always work together in the joint under normal conditions.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Tamura R,Hanesch U,Schmidt RF,Kumazawa T,Mizumura Kdoi
10.1016/s0304-3940(98)00660-0subject
Has Abstractpub_date
1998-09-18 00:00:00pages
53-6issue
1eissn
0304-3940issn
1872-7972pii
S0304-3940(98)00660-0journal_volume
254pub_type
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