Abstract：
:In an attempt to examine a possible relationship between heat shock stress and an induction of amyloid precursor protein, cultured lymphoblastoid cells established from 12 human subjects were treated with heat shock at 42 degrees C for 30 min. The levels of mRNA for amyloid precursor protein (APP), heat shock protein (HSP) 70, and actin were examined by Northern blot at 1, 3, 8, 24, and 48 h after the heat shock treatment. HSP70 mRNA was induced at 1 and 3 h, and became undetectable again by 8 h. APP mRNA was also induced at 3 and 8 h, and recovered to the steady level by 48 h. No induction was observed in actin mRNA. These results indicate that APP mRNA is induced by heat shock treatment after the induction of HSP70 mRNA, suggesting a role of heat shock response in an induction of APP.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Abe K,St George-Hyslop PH,Tanzi RE,Kogure Kdoi
10.1016/0304-3940(91)90019-pkeywords:
subject
Has Abstractpub_date
1991-04-29 00:00:00pages
169-71issue
2eissn
0304-3940issn
1872-7972pii
0304-3940(91)90019-Pjournal_volume
125pub_type
杂志文章abstract：:The electromyographic responses elicited in the first dorsal interosseus muscle by small muscle stretches or by electrical stimulation of the median nerve were investigated in parkinsonian patients and in age-matched healthy subjects. Stimuli were applied during a steady level of contraction in the intrinsic hand musc...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(88)90415-6
更新日期：1988-01-22 00:00:00
abstract：:Using the gerbil model of post-ischemic neuron death in the hippocampal CA1 region, it was recently shown that there is a strong down-regulation of voltage-gated Ca2+ influx in neurons examined at 2 days after the ischemic insult (Connor, J.A., Razani-Boroujerdi, S., Greenwood, A.C., Cormier, R.J., Petrozzino, J.J. an...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(00)01094-6
更新日期：2000-06-02 00:00:00
abstract：:Delivery of alpha-amino-3-hydroxy-5-methylisoxazole-4-proprionate receptors (AMPARs) to the synapse is a critical factor controlling synaptic strength. It is now established that blockade of synaptic activity increases the surface expression of AMPARs. Factors modulating the delivery, insertion and expression of AMPAR...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2006.03.011
更新日期：2006-06-19 00:00:00
abstract：:The effect of unilateral electrical stimulation of the posterior interposate nucleus of the cerebellum was examined on the activity of the nigro-striatal dopaminergic pathways on both sides of the brain in alpha-chloralose anaesthetized cats. Push-pull cannulae were inserted into both caudate nuclei and both substanti...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(80)90079-8
更新日期：1980-04-01 00:00:00
abstract：:The photoactivable compound phenylazide interacts reversibly with the frog's olfactory epithelium when delivered as an olfactory stimulus. Its application together with UV irradiation resulted in a differential reduction of the responses (electro-olfactogram) to several odorants. It was found that this chemical modifi...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(83)90439-1
更新日期：1983-06-30 00:00:00
abstract：:The dopaminergic system has a long history of being associated with reward-related activities but the developmental consequences of blocking dopamine receptor function on reward-based associative learning has been less studied. To this end, male, Long Evans rats were systemically (i.p.) treated with the dopamine recep...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2020.134917
更新日期：2020-04-23 00:00:00
abstract：:The dentate gyrus of the hippocampus is one of few regions in the adult mammalian brain characterized by ongoing neurogenesis. It has been demonstrated that Noggin antagonizes bone morphogenetic protein-4 (BMP4) to create a niche for subventricular zone neurogenesis. We previously demonstrated that Noggin and BMP4 sho...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2004.05.043
更新日期：2004-08-05 00:00:00
abstract：:Visual mental imagery is a process that draws on different cognitive abilities and is affected by the contents of mental images. Several studies have demonstrated that different brain areas subtend the mental imagery of navigational and non-navigational contents. Here, we set out to determine whether there are distinc...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2014.07.008
更新日期：2014-09-05 00:00:00
abstract：:It has been proposed that the perception of a coherent image necessitates two processes, that is, an ensemble of neurons which synchronizes discharges of individual cells and stimulus-specific gamma-band (gamma) neuronal oscillations which may serve as carrier signals for a temporal code. We tested the hypothesis that...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(99)00497-8
更新日期：1999-09-10 00:00:00
abstract：:The goal of the present study was to explore the relation between speed-accuracy trade-off phenomena and action kinematics in the case of pointing under isometric conditions. Increasing task difficulty resulted in a linear increase in movement time (as predicted by Fitts' law) and in systematic changes in the spatio-t...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(00)01089-2
更新日期：2000-05-26 00:00:00
abstract：:DJ-1, the causative gene of a familial form of Parkinson's disease (PD), has been reported undergo oxidation preferentially at the 106th cysteine residue (Cys-106) under oxidative stress. Recently, it has been found that the levels of oxidized DJ-1 in erythrocytes of unmedicated PD patients are markedly higher than th...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2010.08.007
更新日期：2010-10-15 00:00:00
abstract：:Single photon-induced transient currents, called quantum bumps were stimulated by short flashes in dark-adapted ventral nerve photoreceptors of Limulus. Flash intensities were set to activate 3 or more bumps. In most cases, current bumps were activated with a constant rate. The frequency of bump occurrence was between...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(92)90725-m
更新日期：1992-09-14 00:00:00
abstract：:The aim of the present experiment was to study how hypnotic susceptibility and hypnosis affect motoneuron excitability. In a first trial, human subjects were selected according to their hypnotic susceptibility. In a second trial, the Hoffmann (H) reflex amplitude of the soleus muscle was studied in 3 groups: (1) highl...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(89)90347-9
更新日期：1989-09-25 00:00:00
abstract：:Several studies have shown that blockade of colony stimulating factor-1 (CSF-1) or its receptor (CSF-1R) inhibits disease progression in rodent models of rheumatoid arthritis (RA); however, the role of the CSF-1/CSF-1R pathway in RA-induced pain and functional deficits has not been studied. Thus, we examined the effec...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2014.09.053
更新日期：2015-01-01 00:00:00
abstract：:The restoration of motor function is important in daily life in patients with brain damage. Although attentional concentration can affect motor function, most physical therapists focus only on therapeutic exercise. Therefore, we investigated changes in motor function in patients with high attentional concentration dur...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2020.135291
更新日期：2020-09-25 00:00:00
abstract：:Considering the multiplicity of symptoms associated with multiple sclerosis (MS), there is possibility that hypocretin system function might be involved in the pathogenesis of the disease. The current study aimed to investigate the hypocretin-1 levels in cerebrospinal fluid (CSF) of MS patients in relation to differen...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2010.02.062
更新日期：2010-04-19 00:00:00
abstract：:Tourette's syndrome (TS) occurs commonly in children, and dysfunction of dopaminergic system has long been postulated to underlie the disorder. Here, we used two TS rat models induced by 3,3'-iminodipropionitrile (IDPN) and Apomorphine (Apo) to assess an unique dopamine (DA) modulating property of gastrodin (GAS), the...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2014.12.051
更新日期：2015-02-19 00:00:00
abstract：:Around 200,000 veterans (up to 32% of those deployed) of the 1991 Gulf War (GW) suffer from GW illness (GWI), which is characterized by multiple deficits in cognitive, affective, sensory and nociception domains. In this study we employed resting state fMRI (rsfMRI) to map impairments in brain function in GWI with adva...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2019.02.041
更新日期：2019-05-14 00:00:00
abstract：:Dystrobrevin is a newly discovered dystrophin-associated protein that is classified as alpha- and beta-dystrobrevin. Previous studies reported that dystrophin, utrophin, syntrophin and beta-dystroglycan were expressed in the cerebellum. In the present study, we examined cellular and subcellular localization of dystrob...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(00)00925-3
更新日期：2000-04-07 00:00:00
abstract：:Surround inhibition (SI) is a neural mechanism to focus neuronal activity and facilitate selective motor execution (ME). The aim of the present study was to investigate whether SI is also generated during motor imagery (MI). Furthermore, we investigated whether the extent of SI during MI depends on the strength of SI ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2016.07.012
更新日期：2016-08-26 00:00:00
abstract：:In micturition control, the roles of ionotropic glutamate (iGlu) receptors NMDA and AMPA are well established, whereas little is known about the function of metabotropic glutamate (mGlu) receptors. Since antagonists for mGlu5 receptors are efficacious in animal models of inflammatory and neuropathic pain, we examined ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2008.11.026
更新日期：2009-01-23 00:00:00
abstract：:Suicide is a major contributor to the morbidity and mortality of schizophrenia, accounting for approximately 10% of deaths in these patients. Genetic factors have been reported to modulate the risk for suicide, although the precise mechanism and magnitude of the genetic contribution are unknown. Further, suicide attem...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2010.11.079
更新日期：2011-02-11 00:00:00
abstract：:Localization of the epileptogenic zone (EZ) is an important issue in epileptology, even though there is not a unique definition of the epileptic focus. By using complex network analysis of electrocorticographic (ECoG) data we identify three singular areas in the temporal lobe of epileptic patients, the node with highe...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2008.09.080
更新日期：2008-12-12 00:00:00
abstract：:In the present study we sought to determine whether the strain difference in fear reactivity between spontaneously hypertensive rats (SHR) and strain-matched WKY controls might be related to adrenocortical function. SHR and WKY were subjected to adrenalectomy prior to classical fear conditioning. Adrenal cortical ster...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(84)90199-x
更新日期：1984-04-20 00:00:00
abstract：:Temperature effects on ocular serotonin N-acetyltransferase (NAT) kinetics characteristics from Rana perezi have been studied with respect to tryptamine and serotonin as substrates. Monoamine oxidase (MAO) activity does not interfere in NAT assay at acceptoramine concentrations used in NAT kinetics characterization fr...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(93)90667-a
更新日期：1993-05-28 00:00:00
abstract：:Chronic stress is well known to exacerbate pain. We tested the hypothesis that neonatal handling, which induces resilience to the negative impact of stress by increasing the quality and quantity of maternal care, attenuates the mechanical hyperalgesia produced by water-avoidance stress in the adult rat. Neonatal male ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2015.01.066
更新日期：2015-03-30 00:00:00
abstract：:The contribution of NMDA receptors to neuronal hyperexcitability following in vitro ethanol withdrawal was examined using afterdischarges (ADs) in rat dentate gyrus as a model system. ADs were evoked by high frequency stimuli and blocked by N-methyl-D-aspartate (NMDA) receptor antagonists. Ethanol (75 mM) inhibited AD...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(94)91055-3
更新日期：1994-02-14 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2007.01.059
更新日期：2007-04-12 00:00:00
abstract：:The extracellular signal-regulated kinase (ERK) is enriched in the central nervous system, including the dopamine responsive regions such as the striatum and medial prefrontal cortex (mPFC). The kinase is sensitive to changing cellular and synaptic input and is implicated in the regulation of synaptic transmission and...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2019.01.044
更新日期：2019-04-23 00:00:00
abstract：:This study tested the hypothesis that cholinoceptive regions of the medial pontine reticular formation (mPRF), long known to play a role in regulating the sleep cycle, can also causally alter the respiratory cycle. In 4 cats, sleep and wakefulness were polygraphically recorded while simultaneous measures were taken of...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(89)90080-3
更新日期：1989-07-31 00:00:00
