Abstract:
:In the present study we sought to determine whether the strain difference in fear reactivity between spontaneously hypertensive rats (SHR) and strain-matched WKY controls might be related to adrenocortical function. SHR and WKY were subjected to adrenalectomy prior to classical fear conditioning. Adrenal cortical steroids were replaced in some animals. Adrenalectomy produced comparable effects on conditioned fear reactivity in SHR and WKY and steroid replacement reversed the effects of adrenalectomy in both strains. However, a larger dose was required to compensate for adrenalectomy in SHR. These date implicate functions related, directly or indirectly, to the adrenal cortex, in the maintenance of the strain difference in fear reactivity.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Sakaguchi A,LeDoux JE,Sved AF,Reis DJdoi
10.1016/0304-3940(84)90199-xsubject
Has Abstractpub_date
1984-04-20 00:00:00pages
59-64issue
1eissn
0304-3940issn
1872-7972pii
0304-3940(84)90199-Xjournal_volume
46pub_type
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