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Expression analysis of the genes identified in GWAS of the postmortem brain tissues from patients with schizophrenia.

Abstract：

:Many gene expression studies have examined postmortem brain tissues of patients with schizophrenia. However, only a few expression studies of the genes identified in genome-wide association study (GWAS) have been published to date. We measured the expression levels of the genes identified in GWAS (ZNF804A, OPCML, RPGRIP1L, NRGN, and TCF4) of the postmortem brain tissues of patients with schizophrenia and controls from two separate sample sets (i.e., the Australian Tissue Resource Center and Stanley Medical Research Institute). We also determined whether the single-nucleotide polymorphisms (SNPs) identified in the GWAS were related to the gene expression changes in the prefrontal cortex. No difference was observed between the patients with schizophrenia and controls from the Australian Tissue Resource Center samples in the mRNA levels of ZNF804A, OPCML, RPGRIP1L, NRGN, or TCF4. The lack of mRNA change for these five transcripts was also found in the brain samples from the Stanley Medical Research Institute. In addition, no relationship between the schizophrenia-associated SNPs identified in the GWAS and the corresponding gene expression was observed in either sample set. Our results suggest that major changes in the transcript levels of the five candidate genes identified in the GWAS may not occur in adult patients with schizophrenia. The lack of linkage between the risk gene polymorphisms and the expression levels of their major transcripts suggests that the control of pan mRNA levels may not be a prominent mechanism by which the genes identified in the GWAS contribute to the pathophysiology of schizophrenia. Further studies are needed to examine how the genes identified in the GWAS contribute to the pathophysiology of schizophrenia.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Umeda-Yano S,Hashimoto R,Yamamori H,Weickert CS,Yasuda Y,Ohi K,Fujimoto M,Ito A,Takeda M

doi

10.1016/j.neulet.2014.03.031

subject

Has Abstract

pub_date

2014-05-07 00:00:00

pages

12-6

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(14)00230-4

journal_volume

568

pub_type

杂志文章,多中心研究

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Expression analysis of the genes identified in GWAS of the postmortem brain tissues from patients with schizophrenia.