Abstract:
:Microglia are resident immune cells of brain and activated by peripheral tissue injury. In the present study, we investigated the possible induction of several microglial surface immunomolecules in the spinal cord, including leukocyte common antigen (LCA/CD45), MHC class I antigen, MHC class II antigen, Fc receptor, and CD11c following formalin injection into the rat's hind paw. CD45 and MHC class I were upregulated in the activated microglia, which was evident on day 3 with the peak expression on day 7 following peripheral formalin injection. There was a very low basal expression of MHC class II, CD11c, and the Fc receptor, which did not change after the formalin injection. These results, for the first time, indicate that peripheral formalin injection can induce phenotypic changes of microglia with distinct upregulation of CD45 and MHC class I antigen. The data suggest that phenotypic changes of the activated microglia may be a unique pattern of central changes following peripheral tissue injury.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Fu KY,Tan YH,Sung B,Mao Jdoi
10.1016/j.neulet.2008.11.009subject
Has Abstractpub_date
2009-01-16 00:00:00pages
234-9issue
3eissn
0304-3940issn
1872-7972pii
S0304-3940(08)01561-9journal_volume
449pub_type
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