Abstract：
:Intracellular recordings were made of neurons in the myenteric plexus of the guinea-pig distal ileum. Slow excitatory postsynaptic potentials (sEPSPs) were evoked by electrical stimulation of an interganglionic fibre tract. The effect of cholecystokinin (CCK) receptor antagonists on the sEPSPs was investigated in 11 neurons. Application of the CCK receptor antagonists L-364,718 and L-365,260 (each 250 nM) markedly attenuated the sEPSPs in five of 11 neurons. The amplitude of the sEPSP reduced from 15 +/- 3 to 7 +/- 2 mV and the change in membrane resistance during the sEPSP was reduced from 28 +/- 9 to 11 +/- 8 MS. In six of 11 neurons the CCK antagonists had no effect on the sEPSPs. The results provide evidence that neurally released CCK is involved in the mediation of sEPSPs in some enteric neurons.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Schutte IW,Hollestein KB,Akkermans LM,Kroese ABdoi
10.1016/s0304-3940(97)00786-6subject
Has Abstractpub_date
1997-11-07 00:00:00pages
155-8issue
3eissn
0304-3940issn
1872-7972pii
S0304394097007866journal_volume
236pub_type
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