Pinprick hypo- and hyperalgesia in diabetic rats: Can diet content affect experimental outcome?

Abstract:

:Existing literature concerning the effect of experimentally-induced diabetes on pain thresholds in rodent models remains controversial. In this work, we describe a phenotypical switch from streptozotocin-induced pinprick hypoalgesia to hyperalgesia observed in the same laboratory, in the same strain of rats, obtained from the same vendor, and measured by the same technique carried out by the investigators. This switch was observed around January 2015, at the time when there was a change in the diet of rats at the Radley North Carolina Charles River facility. These data support the contention that diet may significantly modify disease progression, including progression of signs of diabetic neuropathy.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Yadlapalli JSK,Dogra N,Walbaum AW,Prather PL,Crooks PA,Dobretsov M

doi

10.1016/j.neulet.2018.02.054

subject

Has Abstract

pub_date

2018-04-23 00:00:00

pages

24-27

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(18)30142-3

journal_volume

673

pub_type

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