Abstract:
:Existing literature concerning the effect of experimentally-induced diabetes on pain thresholds in rodent models remains controversial. In this work, we describe a phenotypical switch from streptozotocin-induced pinprick hypoalgesia to hyperalgesia observed in the same laboratory, in the same strain of rats, obtained from the same vendor, and measured by the same technique carried out by the investigators. This switch was observed around January 2015, at the time when there was a change in the diet of rats at the Radley North Carolina Charles River facility. These data support the contention that diet may significantly modify disease progression, including progression of signs of diabetic neuropathy.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Yadlapalli JSK,Dogra N,Walbaum AW,Prather PL,Crooks PA,Dobretsov Mdoi
10.1016/j.neulet.2018.02.054subject
Has Abstractpub_date
2018-04-23 00:00:00pages
24-27eissn
0304-3940issn
1872-7972pii
S0304-3940(18)30142-3journal_volume
673pub_type
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