Selective attenuation of mu-opioid receptor-mediated effects in rat sensory neurons by intrathecal administration of antisense oligodeoxynucleotides.

abstract：:Mouse neuroblastoma x rat glioma hybrid cells (N x G, NG108-15) were used to study the mechanism of Ca(2+)-current (ICa) inhibition by 5-hydroxytryptamine (5-HT). 5-HT caused a dose-dependent decrease of ICa which was abolished by ICS 205-930 (10)(-8) M) while 2-methyl-5-HT was an agonist. Intracellular infusion of GD...

journal_title：Neuroscience letters

authors： Eckert R,Utz J,Trautwein W

更新日期：1993-04-16 00:00:00

abstract：:The topography of parvalbumin-immunoreactive neurons within the ventrolateral medulla of rats was investigated. Parvalbumin is a member of the 'EF-hand' family of Ca-binding proteins and is present in certain cell types within the central nervous system (fast-firing neurons with high metabolic rates). Parvalbumin-immu...

journal_title：Neuroscience letters

authors： Cox M,Halliday GM

更新日期：1993-09-17 00:00:00

abstract：:Ifenprodil is an atypical N-methyl-D-aspartate (NMDA) receptor antagonist that selectively blocks receptors containing the NR2B subunit. It has been proposed that ifenprodil may act at a stimulatory polyamine site on NMDA receptors, although interactions between ifenprodil and polyamines are non-competitive. NMDA rece...

journal_title：Neuroscience letters

authors： Pahk AJ,Williams K

更新日期：1997-03-28 00:00:00

abstract：:Long-term potentiation (LTP) of perforant-path dentate granule cell synapses, in awake rats, was followed by a time-dependent expression of brain-derived neurotrophic factor (BDNF) mRNA in dentate granule cells. This BDNF expression was blocked by the N-methyl-D-aspartate (NMDA) antagonist dizocilpine maleate (MK-801)...

journal_title：Neuroscience letters

authors： Dragunow M,Beilharz E,Mason B,Lawlor P,Abraham W,Gluckman P

更新日期：1993-10-01 00:00:00

abstract：:In order to determine if an event-related brain potential (ERP) effect described for syntactic violations (P600/SPS) varies with the amount of reprocessing entailed by a violation, number incongruencies were presented either within simple declarative or within subordinate clauses. ERPs were recorded while 12 German su...

journal_title：Neuroscience letters

authors： Münte TF,Szentkuti A,Wieringa BM,Matzke M,Johannes S

更新日期：1997-10-17 00:00:00

abstract：:Alpha-2 macroglobulin (A2M) is a component of Lewy bodies, a hallmark of Parkinson's disease (PD). In 159 PD patients and 190 normal controls, we studied two A2M polymorphisms by the polymerase chain reaction-restriction fragment length polymorphism method: a five-nucleotide deletion at the 5' splice site of exon 18; ...

journal_title：Neuroscience letters

authors： Nicoletti G,Annesi G,Tomaino C,Spadafora P,Pasqua AA,Annesi F,Serra P,Caracciolo M,Messina D,Zappia M,Quattrone A

更新日期：2002-08-02 00:00:00

abstract：:A replication-defective recombinant adenoviral vector containing E. coli lacZ gene was injected into the gastrocnemius muscles of transgenic mice carrying mutant Cu/Zn superoxide dismutase (SOD1) gene and non-transgenic wild-type mice at 40 weeks of age. After 60 and 90 h of the injection, lacZ staining was observed a...

journal_title：Neuroscience letters

authors： Murakami T,Nagano I,Hayashi T,Manabe Y,Shoji M,Setoguchi Y,Abe K

更新日期：2001-08-10 00:00:00

abstract：:In complex regional pain syndrome (CRPS) many clinical symptoms suggest involvement of the central nervous system. Neuropathic pain as the leading symptom is often resistant to therapy. In the present study we investigated the analgesic efficiency of repetitive transcranial magnetic simulation (rTMS) applied to the mo...

journal_title：Neuroscience letters

authors： Pleger B,Janssen F,Schwenkreis P,Völker B,Maier C,Tegenthoff M

更新日期：2004-02-12 00:00:00

abstract：:Daily administration of clonidine for 5 weeks (approx. 300 micrograms/kg/day, p.o.) produced significant decreases in blood pressure and renal sympathetic efferent activity in spontaneously hypertensive rats (SHR). After cessation of clonidine administration, blood pressure and sympathetic nerve activity recovered rap...

journal_title：Neuroscience letters

authors： Yomaida I,Murao M,Togashi H,Shimamura K,Koike Y,Monma Y,Saito HA

更新日期：1979-12-01 00:00:00

abstract：:We examined the somatotopical relationship between cortical activity and sensory stimulation of reflex areas in reflexology using functional magnetic resonance imaging. Three reflex areas on the left foot, relating to the eye, shoulder, and small intestine were stimulated during the experiment. A statistical analysis ...

journal_title：Neuroscience letters

authors： Nakamaru T,Miura N,Fukushima A,Kawashima R

更新日期：2008-12-19 00:00:00

abstract：:gamma-Aminobutyric acidA (GABA(A)) gated chloride ion channels were expressed from human recombinant cDNA using the baculovirus/Sf-9 insect cell expression system. The electrophysiological effects in whole-cell currents of 5-(4-piperidyl) isoxazol-3-ol (4-PIOL), a GABA(A) receptor partial agonist, were investigated on...

journal_title：Neuroscience letters

authors： Westh-Hansen SE,Noguchi K,Witt MR,Murai Y,Nielsen M,Akaike N

更新日期：1997-07-11 00:00:00

abstract：:Incorporation of the N-methyl-d-aspartate receptor (NMDAR) subunit NR3A into functional NMDARs results in reduced channel conductance and Ca(2+) permeability. To further investigate the function of NR3A, we have set out to characterize its intracellular binding partners. Here, we report a novel protein interaction bet...

journal_title：Neuroscience letters

authors： Eriksson M,Samuelsson H,Björklund S,Tortosa E,Avila J,Samuelsson EB,Benedikz E,Sundström E

更新日期：2010-05-07 00:00:00

abstract：:Intracellular and extracellular recordings were obtained from layers II-III of slices of adult rat neocortex maintained in vitro. Excitatory postsynaptic potentials (EPSPs) and epileptiform discharges (paroxysmal depolarizing shifts, PDSs) were evoked in the presence of bicuculline methiodide. Responses were monitored...

journal_title：Neuroscience letters

authors： Burke JP,Hablitz JJ

更新日期：1994-06-06 00:00:00

abstract：:Cocaethylene is an active cocaine metabolite that targets mammalian neural reward pathways and thus contributes to the reinforcing and addictive properties of ethanol and cocaine. Using gas chromatography-mass spectrometry, we find that fruit flies (Drosophila melanogaster) possess a cellular mechanism through which c...

journal_title：Neuroscience letters

authors： Torres G,Horowitz JM

更新日期：1999-03-26 00:00:00

abstract：:Partial depolarization of primary cerebellar neuronal cultures with K+ evoked the release of aspartate, glutamate, adenosine, serine, taurine, gamma-aminobutyric acid (GABA), alanine and proline. The dihydropyridine calcium channel agonist, BAY K 8644, significantly augmented the K+-induced release of adenosine, aspar...

journal_title：Neuroscience letters

authors： Philibert RA,Dutton GR

更新日期：1989-07-17 00:00:00

abstract：:Neural stem cells (NSCs) have been the focus of an intensive effort to direct their differentiation in vitro towards desired neuronal phenotypes for cell replacement therapies. It is thought that NSCs derived from older embryos have limited neurogenic capacity and are restricted towards an astroglial fate. This idea i...

journal_title：Neuroscience letters

authors： Hegarty SV,Spitere K,Sullivan AM,O'Keeffe GW

更新日期：2014-01-24 00:00:00

abstract：:We have investigated whether administration of staurosporine, which has been reported to induce differentiation in the human neuroblastoma cell in vitro, attenuates amnesia induced by basal forebrain lesion in rats. Multiple dosage of staurosporine at the doses of 0.05 and 0.1 mg/kg (i.p.) attenuated the impaired perf...

journal_title：Neuroscience letters

authors： Nabeshima T,Ogawa S,Nishimura H,Fuji K,Kameyama T,Sasaki Y

更新日期：1991-01-14 00:00:00

abstract：:When a tone-burst train with a short inter-burst interval is lateralized to the left and is followed by another tone-burst train lateralized to the right, listeners report a smooth shift of tone bursts along the intracranial axis from left to right (known as auditory saltation). When a sequence of tone bursts with a c...

journal_title：Neuroscience letters

authors： Kawabe T

更新日期：2010-01-14 00:00:00

abstract：:There is evidence to support that oxidative stress is increased in Parkinson's disease (PD) and contributes to the degeneration of dopaminergic neurons. Recent research has shown that higher blood urate concentrations have now been linked to decreased risks and progression rates of PD. However, the mechanisms about ur...

journal_title：Neuroscience letters

authors： Zhu TG,Wang XX,Luo WF,Zhang QL,Huang TT,Xu XS,Liu CF

更新日期：2012-01-11 00:00:00

abstract：:Methyl-CpG binding protein 2 (MECP2) is a chromosome-binding protein that regulates the development and maintenance of brain circuits. Altered function of the protein product of MECP2 plays an important role in the etiology of many neurodevelopmental disorders. Mutations involving a loss of function are implicated in ...

journal_title：Neuroscience letters

authors： Tropea D,Mortimer N,Bellini S,Molinos I,Sanfeliu A,Shovlin S,McAllister D,Gill M,Mitchell K,Corvin A

更新日期：2016-05-16 00:00:00

abstract：:Reactive oxygen species (ROS), such as superoxide and hydrogen peroxide, play essential roles in physiological plasticity and are also involved in the pathogenesis of persistent pain. Roles of peripheral and spinal ROS in pain have been well established, but much less is known about ROS in the amygdala, a brain region...

journal_title：Neuroscience letters

authors： Lu YF,Neugebauer V,Chen J,Li Z

更新日期：2016-04-21 00:00:00

abstract：:Most single fibers of the cochlear nerve (CN) in 22 cats exhibited effects of mechanical interaction in one cochlea between two sounds applied binaurally, similarly to results in two cats in which the contralateral CN was transected. In 11 of 189 fibers, the spontaneous and/or the sound-evoked activity was suppressed ...

journal_title：Neuroscience letters

authors： Murata K,Tanahashi T,Horikawa J,Funai H

更新日期：1980-07-01 00:00:00

abstract：:The act of tasting is the product of inseparable integrative behavior consisting of multi-sensory processing and orolingual motor coordination. Often tasting-induced brain activity is looked at in a reductionist manner as a set of isolated components. However, brain activity as a whole during tasting may not simply be...

journal_title：Neuroscience letters

authors： Okamoto M,Dan H,Clowney L,Yamaguchi Y,Dan I

更新日期：2009-02-20 00:00:00

abstract：:Anatomical relationships of hypothalamic cocaine- and amphetamine-regulated transcript (CART) with other hypothalamic neuropeptides were examined by using in situ hybridization histochemistry and immunohistochemistry. CART mRNA was found in various regions in rat hypothalamus, including the periventricular nucleus, pa...

journal_title：Neuroscience letters

authors： Li HY,Hwang HW,Hu YH

更新日期：2002-05-03 00:00:00

abstract：:Against the current concept of abortive regeneration of axotomized neurons in the mammalian central nervous system, the occurrence of remarkable axonal regeneration of cerebellothalamic projection neurons following transection of the decussation of the superior cerebellar peduncle was proved in kittens morphologically...

journal_title：Neuroscience letters

authors： Kawaguchi S,Miyata H,Kawamura M,Harada Y

更新日期：1981-08-07 00:00:00

abstract：:This study assessed the effect of the kappa opioid receptor agonist U50,488 administered into the rat temporomandibular joint (TMJ) on nociceptive behavioral responses evoked by formalin injected into the same site. Groups consisted of females, stratified into proestrus and diestrus phases of the estrous cycle, and ma...

journal_title：Neuroscience letters

authors： Clemente JT,Parada CA,Veiga MC,Gear RW,Tambeli CH

更新日期：2004-12-06 00:00:00

abstract：:Although the mechanisms of visual short term memory (VSTM) are extensively investigated in the recent decade, how we compare the representation stored in VSTM to the perceptual input to detect and process the mismatch information remains largely unclear. The current study explored whether there is an ERP component tra...

journal_title：Neuroscience letters

authors： Yin J,Gao Z,Jin X,Ye L,Shen M,Shui R

更新日期：2011-03-10 00:00:00

abstract：:The breakdown in brain ionic homeostasis during energy deprivation (anoxic depolarization [AD]) is intimately linked to neuronal injury. We studied the role of one particular route of Na+ influx, voltage-sensitive Na+ channels, in the AD induced by O2 and/or glucose deprivation. We recorded extracellular Na+ concentra...

journal_title：Neuroscience letters

authors： Fung ML,Croning MD,Haddad GG

更新日期：1999-11-05 00:00:00

abstract：:The structural specificity of alpha-PMTX, a novel peptide toxin derived from wasp venom has been studied on the neuromuscular synapse in the walking leg of the lobster. alpha-PMTX is known to induce repetitive action potentials in the presynaptic axon due to sodium channel inactivation. We synthesized 29 analogs of al...

journal_title：Neuroscience letters

authors： Konno K,Hisada M,Naoki H,Itagaki Y,Yasuhara T,Nakata Y,Miwa A,Kawai N

更新日期：2000-05-05 00:00:00

abstract：:The objective of the study was to investigate the presence and distribution of nerve cell bodies and small ganglia in the stroma of human submandibular gland. A retrospective immunohistochemical study in 13 human submandibular glands, fixed in neutral buffered formalin and embedded in paraffin wax, was undertaken. Six...

journal_title：Neuroscience letters

authors： Tosios KI,Nikolakis M,Prigkos AC,Diamanti S,Sklavounou A

更新日期：2010-05-07 00:00:00