Abstract：
:Ciliary neurotrophic factor (CNTF) is known as a neuro-survival factor in the developing and developed CNS, as well as in the CNS following injury. However, little is known about the expression of CNTF or that of its receptor (CNTFR-alpha) in cases of intracerebral hemorrhage (ICH). We investigated the temporal and spatial profiles of CNTF and CNTFR-alpha expression using a collagenase-induced ICH rat model. CNTF expression was up-regulated from the day following ICH induction and reached a peak level at 5 to 14 days, with increased expression observed in brain tissue surrounding the hematoma lesion and white matter structures in association with astroglial proliferation. Further, CNTFR-alpha was transiently expressed in the cerebral cortex surrounding the hematoma, with a peak at 5 days. Administration of exogenous CNTF into the lesion following initiation of ICH resulted in a prolonged expression of CNTFR-alpha on cortical neurons neighboring the hematoma. Our findings suggest differential regulation of CNTF and CNTFR-alpha, and the possibility of a therapeutic strategy using CNTF administration for ICH.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Yokota H,Yoshikawa M,Hirabayashi H,Nakase H,Uranishi R,Nishimura F,Sugie Y,Ishizaka S,Sakaki Tdoi
10.1016/j.neulet.2004.11.093keywords:
subject
Has Abstractpub_date
2005-04-04 00:00:00pages
170-5issue
3eissn
0304-3940issn
1872-7972pii
S0304-3940(04)01505-8journal_volume
377pub_type
杂志文章abstract：:In control samples, intense acoustic "go" stimuli accelerate the central and peripheral motor processes that compose simple reaction time movements. The goal of the current study was to determine whether movements that are initiated to intense acoustic cues facilitate simple reaction times in (1) adults with chronic s...
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：1979-08-01 00:00:00
