Abstract:
:The actions of agonists and antagonists of excitatory amino acid receptors were studied in the isolated ileal longitudinal muscle-myenteric plexus preparation of the guinea pig incubated 'in vitro', by recording the contraction of the longitudinal muscle. L-Glutamate, L-aspartate, quinolinate and N-methyl-D-aspartate (NMDA), in concentrations ranging from 10(-6) to 10(-4) M, induced a rapid contraction of this preparation while kainate and quisqualate were not active at a concentration of 10(-4) M. The excitatory amino acid responses were competitively antagonized by 2-amino-5-phosphonovalerate. They were also prevented by Mg2+ ions (0.1-1 mM), by tetrodotoxin 3 X 10(-6) M and by hyoscine 10(-7) M. The last observations suggest that the myenteric cholinergic interneurons are in some way involved in the glutamate-induced ileal contraction. These results demonstrate the existence of receptors for excitatory amino acids (possibly of NMDA type) in the myenteric plexus of the guinea pig.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Moroni F,Luzzi S,Franchi-Micheli S,Zilletti Ldoi
10.1016/0304-3940(86)90229-6subject
Has Abstractpub_date
1986-07-11 00:00:00pages
57-62issue
1eissn
0304-3940issn
1872-7972pii
0304-3940(86)90229-6journal_volume
68pub_type
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