Abstract:
:The neurotoxin 6-hydroxydopamine (6-OHDA) is used to induce dopaminergic cell death, resulting in insufficient striatal dopamine content in the basal ganglia and motor dysfunction typical of Parkinson's disease. Dopamine induces release of the neuropeptide substance P (SP) within the substantia nigra, whereas SP is able to potentiate striatal dopamine release, thus creating a positive feedback mechanism. Previous studies, however, have shown that elevated SP is detrimental to neuronal survival and motor function in acute brain injury. In the current study, we demonstrate that 6-OHDA increases SP production in meso-striatal organotypic co-culture. Moreover, there was a significant correlation between SP content and lactate dehydrogenase release, a marker of cell death, suggesting elevated SP production may contribute to 6-OHDA induced cell death in vitro.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Thornton E,Tran TT,Vink Rdoi
10.1016/j.neulet.2010.06.057subject
Has Abstractpub_date
2010-08-30 00:00:00pages
64-7issue
1eissn
0304-3940issn
1872-7972pii
S0304-3940(10)00831-1journal_volume
481pub_type
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