Abstract:
:Bone mesenchymal stem cells (BMSCs) are an attractive donor graft source because of the potential of self-renewal and multi-direction differentiation. However, it is a great challenge to induce BMSCs to specifically differentiate to dopamine (DA) neurons for the treatment of Parkinson's disease. Because the striatum is the target tissue for the projection of DA neurons in the midbrain, we investigated whether its extracts could promote the dopaminergic differentiation of BMSCs. BMSCs were isolated from green fluorescent protein (GFP) transgenic mice. Flow cytometry was used to identify the expression of CD29 and CD11b in cultured BMSCs; and immunochemical staining was employed to determine the differentiation of BMSCs. Our results showed that striatal extracts could induce differentiation of BMSCs into both neurons and glia, especially the DA neurons. When transplanted to the rat striatum, GFP-BMSCs could differentiate into tyrosine hydroxylase positive neurons and demonstrate potential migration in the brain. Taking together, our results suggest that striatal extracts can specifically promote the dopaminergic differentiation of GFP-BMSCs, thereby providing a feasible strategy for the treatment of Parkinson's disease.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Yang S,Gao Q,Bao L,Zhang J,Hu Y,Bing L,Sun J,Hao J,Chen C,Li S,Poon WS,Sun J,Gao Ydoi
10.1016/j.neulet.2012.09.063subject
Has Abstractpub_date
2012-11-21 00:00:00pages
115-20issue
2eissn
0304-3940issn
1872-7972pii
S0304-3940(12)01328-6journal_volume
530pub_type
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