Abstract：
:A valinomycin-based membrane phase for microelectrodes with relatively low electrical membrane resistances is described. Microelectrodes with tip diameters of about 1 micron exhibit resistances of about 10(10) omega. Extremely high K+ selectivities are obtained, e.g. a rejection of Na+ by a factor of 5000 and of acetylcholine by a factor of 3400. At a constant background of 140 and 500 mM Na+, the detection limit of the K+ sensor is at 1.6 X 10(-5) and at 2.5 X 10(-5) M K+, respectively.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Ammann D,Chao PS,Simon Wdoi
10.1016/0304-3940(87)90153-4subject
Has Abstractpub_date
1987-02-24 00:00:00pages
221-6issue
2eissn
0304-3940issn
1872-7972pii
0304-3940(87)90153-4journal_volume
74pub_type
杂志文章abstract：:The aim of the present experiment was to study how hypnotic susceptibility and hypnosis affect motoneuron excitability. In a first trial, human subjects were selected according to their hypnotic susceptibility. In a second trial, the Hoffmann (H) reflex amplitude of the soleus muscle was studied in 3 groups: (1) highl...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(89)90347-9
更新日期：1989-09-25 00:00:00
abstract：:Traumatic injury to the central nervous system (CNS) results in the breakdown of the blood-brain barrier and recruitment of hematogenous cells at the site of injury. The role of chemokines in this process has been well recognized and they have been regarded as promising targets for development of anti-inflammatory the...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(98)00268-7
更新日期：1998-05-08 00:00:00
abstract：:Alzheimer' disease is a neurodegenerative disorder characterized by the misfolding and aggregation of amyloid β (Aβ). This process is influenced through supply of cholesterol via apolipoproteins to neurons. In the present study, we used the transgenic Caenorhabditis elegans strain CL2006, which expresses Aβ1-42 under ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2014.05.059
更新日期：2014-07-25 00:00:00
abstract：:Sympathoexcitatory neurons in the C1 adrenergic area of the rostral ventrolateral medulla (RVL) are tonically inhibited by gamma-aminobutyric acid (GABA). To identify the source of this GABAergic input, the distribution of neurons containing glutamate decarboxylase (GAD) was determined immunocytochemically in rats tre...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(85)90333-7
更新日期：1985-07-04 00:00:00
abstract：:In this work, we attempt to extend to the schizophrenia's research the evidence that different frequency bands may emerge from different sources during early-stage visual processing, in a mental state-specific manner, while subjects are passively viewing a visual stimulus. We applied standard pattern reversal stimulat...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2008.10.109
更新日期：2009-01-23 00:00:00
abstract：:In neuro-inflammatory diseases, activated T cells are thought to drive the inflammatory process. In this study, we investigated the potential role of three T cell attracting chemokines (CK) in neuro-inflammation. For this purpose, we measured levels of CXCL16, CCL17 and CCL18 in matched serum and cerebrospinal fluid (...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2005.12.029
更新日期：2006-04-10 00:00:00
abstract：:We have assessed whether apolipoprotein E (ApoE) genotype influences the age of onset of dementia in a series of families with frontal temporal dementia with defined mutations in the tau gene. In contrast to the situation in Alzheimer's disease (AD), we could find no evidence that the age of onset of disease was influ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(98)00931-8
更新日期：1999-02-05 00:00:00
abstract：:We have studied the electrophysiological properties of enzymatically dissociated adult pigeon semicircular canal type I (chalice shaped) and type II (cylindrical shaped) hair cells using whole cell patch clamp techniques. Under current clamp conditions, type I hair cells often exhibit more hyperpolarized resting poten...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(90)90394-o
更新日期：1990-08-14 00:00:00
abstract：:By means of a new photographic method to quantitate catecholamine fluorescence in tissue sections it has been possible to demonstrate a high dopamine (DA) turnover within the DA cell bodies of the midbrain. The medially located small-sized DA cell bodies of the A10 DA cell group has a very high DA turnover which was s...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(80)90211-6
更新日期：1980-05-15 00:00:00
abstract：:Our previous work has shown that repetitive stimulation of Adelta-fibers depresses long-term potentiation (LTP) of C-fiber evoked field potentials in spinal dorsal horn. Here, we tested the effects of the Adelta stimulation on the spinal LTP at different time points following LTP induction. Fifteen minutes after LTP i...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(01)02343-6
更新日期：2001-11-23 00:00:00
abstract：:The effect of systemic morphine (5 mg/kg) on the C-fibre evoked activity in the dorsal horn of decerebrate spinalized rats has been investigated. Activity in units recorded from lamina 5 was inhibited in a naloxone-reversible fashion by morphine. However, morphine produced variable changes in the C-evoked activity of ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(81)90097-5
更新日期：1981-08-07 00:00:00
abstract：:On the basis of the recent cloning of the beta-secretase, the beta-site amyloid precursor protein (APP)-cleaving enzyme (BACE), (Science, 286 (1999) 735), digoxigenin-labelled riboprobes were generated to localize the cellular expression pattern of BACE mRNA in brain sections of transgenic Tg2576 mice, overexpressing ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(00)01452-x
更新日期：2000-10-06 00:00:00
abstract：:In addition to providing structural, metabolic and trophic support to neurons, glial cells of the central, peripheral and enteric nervous systems (CNS, PNS, ENS) respond to and regulate neural activity. One of the most well characterized features of this response is an increase of intracellular calcium. Astrocytes at ...
journal_title：Neuroscience letters
pub_type： 杂志文章,评审
doi：10.1016/j.neulet.2020.134959
更新日期：2020-06-11 00:00:00
abstract：:In an attempt to elucidate the possible mechanisms involved in the development of the thermoregulatory disturbances induced by systemic capsaicin treatment, the effects of 5-HT injected into the preoptic region or into the cisterna magna on the body temperature and on tail skin vasodilation were studied in control and...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(85)80124-5
更新日期：1985-02-28 00:00:00
abstract：:The depth and complexity of the non-coding transcriptome in nervous system tissues provides a rich substrate for adenosine de-amination acting on RNA (ADAR). Non-coding RNAs (ncRNAs) serve diverse regulatory and computational functions, coupling signal flow from the environment to evolutionarily coded analog and digit...
journal_title：Neuroscience letters
pub_type： 杂志文章,评审
doi：10.1016/j.neulet.2009.09.009
更新日期：2009-12-04 00:00:00
abstract：:The contribution of NMDA receptors to neuronal hyperexcitability following in vitro ethanol withdrawal was examined using afterdischarges (ADs) in rat dentate gyrus as a model system. ADs were evoked by high frequency stimuli and blocked by N-methyl-D-aspartate (NMDA) receptor antagonists. Ethanol (75 mM) inhibited AD...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(94)91055-3
更新日期：1994-02-14 00:00:00
abstract：:Stimulation of type-1 astrocytes, by a number of agonists, has been shown to increase cytosolic Ca2+ concentrations in an oscillatory manner. However, it is unknown how these are driven or altered by aging, injury or disease. Therefore, we characterized the signaling properties of rat type-1 astrocytes in monolayer cu...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2005.10.088
更新日期：2006-03-06 00:00:00
abstract：:Horseradish peroxidase (HRP) was injected into the thalamic ventral tier of squirrel monkey and the brainstem was examined for the presence of HRP-reactive cells in the external cuneate nucleus (ECN), nuclei Z and X, and the mesencephalic nucleus of the trigeminal nerve (MNV). Results indicate that the ECN, Z and X ha...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(83)90220-3
更新日期：1983-10-31 00:00:00
abstract：:Membrane currents of cultured human monocytes and rat microglia were recorded with the whole-cell patch clamp technique. Freshly isolated monocytes or resting (proliferating) microglia express only inwardly rectifying K+ channels. However, incubation in teflon bags leads to the expression of additional, outwardly rect...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(93)9001-0
更新日期：1993-09-17 00:00:00
abstract：BACKGROUND/AIM:Depressive disorders are multifactorial diseases, in which cognitive impairment is one of the characteristic feature. One of the molecules that regulate of various cognitive, emotional and behavioural processes is nitric oxide (NO), synthesized from l-arginine by a family of isoformic enzymes known as ni...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2012.01.018
更新日期：2012-02-29 00:00:00
abstract：:This paper presents additional evidence showing the persistent functional deficits in concussed athletes as revealed by altered movement-related cortical potentials (MRCP) preceding whole body postural movements at least 30 days post-injury. Eight student-athletes participated in this study (a) prior to injury; and (b...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2005.04.039
更新日期：2005-08-05 00:00:00
abstract：:Following unilateral transection of the medial forebrain bundle (MFB) within the anterior hypothalamic-preoptic region of cats, the biting attack upon a rat elicited by ipsilateral posterior hypothalamic or ventral midbrain stimulation is eliminated, although the cat continues to approach from 2.8 metres away to withi...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(81)90387-6
更新日期：1981-01-20 00:00:00
abstract：:Novel paired ependymal ridges (EPRS) have been identified in the ventrolateral wall of the cerebral aqueduct of the rat. Scanning electron microscopic techniques revealed that the dorsolateral and ventromedial ridges differ from each other in surface morphology. Using the PAP immunohistochemical technique, the EPRS de...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(81)90196-8
更新日期：1981-11-18 00:00:00
abstract：:Mutations in the glucocerebrosidase gene (GBA) have recently been associated with an increased risk of Parkinson disease (PD). GBA mutations have been observed to be particularly prevalent in the Ashkenazi Jewish population. Interestingly, this population also has a high incidence of the Lrrk2 p.G2019S mutation which ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2009.11.066
更新日期：2010-06-21 00:00:00
abstract：:The processing of sound information is mediated by the cochlea and the central auditory system. Among the central auditory system, the inferior colliculus (IC) has leading roles in the acoustic processing. In a previous study, we demonstrated psychiatric disorder-related behavioral abnormalities in a genetically modif...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2014.02.061
更新日期：2014-04-30 00:00:00
abstract：:The purpose of this study was to investigate how the recruitment gain, as derived from the Hoffmann (H)-reflex measurement, of antagonistic motoneurons is modulated during voluntary lengthening (LEN) and shortening (SHO) contractions in the human tibialis anterior (TA) muscle. To this end, the parameters of the ratios...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(03)00241-6
更新日期：2003-05-15 00:00:00
abstract：:Genetic polymorphism has been reported in the 3'-untranslated region (3'-UTR) of the human dopamine transporter (DAT) gene and the variable number of tandem repeat (VNTR) polymorphism has been proposed to be associated with normal personal traits or psychoneurological disorders. To assess the variation of this region ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(02)01125-4
更新日期：2002-12-16 00:00:00
abstract：:To clarify the possible involvement of protein kinase (PK) C activation in the excitation and sensitization of polymodal receptors (PMRs), the effects of phorbol 12,13-dibutyrate (PDBu) on PMRs were studied in canine testis-spermatic nerve preparations in vitro. Application of PDBu (10(-7), 10(-6), AND 10(-5) M) for 5...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(96)12414-9
更新日期：1996-03-08 00:00:00
abstract：:We have studied the electrophysiological properties of hippocampal neurons grown on surfaces of organic thin films formed on glass or silicon substrates and on microelectronic device surfaces in culture. Hippocampal neurons were dissociated from embryonic rats and plated on substrates chemically modified with laminin ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(97)13372-9
更新日期：1997-02-14 00:00:00
abstract：:Many experimental observations have demonstrated the modulatory role exerted by several neural structures and neurotransmitters on spontaneous and paroxysmal bioelectric activity of the hippocampus. Recently, the control exerted by locus coeruleus (LC) and its noradrenergic (NA) efferent pathway on different experimen...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(94)90364-6
更新日期：1994-03-14 00:00:00
