Glucocerebrosidase mutations are not a common risk factor for Parkinson disease in North Africa.

abstract：:Electrical stimulation delivered to the rostral pons induced well coordinated activity of the intralaryngeal muscles and the ventilatory muscles for vocalization in unanesthetized, decerebrate cats. The stimulation reset the normal respiratory rhythm and induced vocalization with a newly developed rhythm. Continuous o...

journal_title：Neuroscience letters

authors： Sakamoto T,Yamanaka Y,Wada K,Nakajima Y

更新日期：1993-08-06 00:00:00

abstract：:Both chronic pain and depression are debilitating diseases, which often coexist in clinic. However, current analgesics and antidepressants exhibit limited efficacy for this comorbidity. The present study aimed to investigate the effect of ketamine on the comorbidity of inflammatory pain and consequent depression-like ...

journal_title：Neuroscience letters

authors： Zhang GF,Wang J,Han JF,Guo J,Xie ZM,Pan W,Yang JJ,Sun KJ

更新日期：2016-09-19 00:00:00

abstract：:A method for the histochemical demonstration of cells with the capacity to synthesize the enzyme GABA-transaminase is described. Intraventricular injection of ethanolamine-O-sulfate irreversibly inhibits brain GABA-transaminase activity. Within 17 h after the injection sufficient new enzyme is synthesized to allow his...

journal_title：Neuroscience letters

authors： Vincent SR,Kimura H,McGeer EG

更新日期：1980-03-01 00:00:00

abstract：:Associations between PIN1 gene polymorphisms and Alzheimer's disease (AD) risk remain controversial, possibly because single studies often lack sufficient statistical power. In this study, we performed a meta-analysis to evaluate the association of two commonly studied PIN1 polymorphisms, -842G/C and -667T/C, with the...

journal_title：Neuroscience letters

authors： Cao L,Wang F,Ge H,Wu PC,Qu P,Chen GH,Gao ZL

更新日期：2013-02-22 00:00:00

abstract：:The pathogens of Alzheimer's disease (AD) are still unclear, while accumulating evidences have indicated that both genetic and environmental factors are involved in the pathogenesis of AD. Recent studies suggest that AD is primarily a vascular disorder and copper (Cu) may play an important role in AD pathology. Howeve...

journal_title：Neuroscience letters

authors： Mao X,Ye J,Zhou S,Pi R,Dou J,Zang L,Chen X,Chao X,Li W,Liu M,Liu P

更新日期：2012-06-14 00:00:00

abstract：:Propofol has been demonstrated as a drug of abuse in humans. Our previous study indicated that dexamethasone, a potent agonist of glucocorticoid receptor (GR), inhibited propofol-maintained rat self-administration behaviors by systematic injection. However, the direct effect of GR in the nucleus accumbens (NAc) on pro...

journal_title：Neuroscience letters

authors： Wu B,Lin W,Wang H,Abdullah T,Wang B,Su Y,Ge RS,Lian Q

更新日期：2018-01-01 00:00:00

abstract：:Emotions are at the core of human cognition and behavior. Traditionally, emotions have been classified dichotomously as being either positive or negative. However, recent behavioral research (An et al., 2017) suggests that emotions contain both positivity and negativity. The current work investigated neural correlates...

journal_title：Neuroscience letters

authors： An S,Han X,Wu B,Shi Z,Marks M,Wang S,Wu X,Han S

更新日期：2018-09-25 00:00:00

abstract：:Neuronal recording and neuroimaging studies have shown that the primary motor area (M1) not only participates in motor execution, but is also engaged during movement preparation. The purpose of the present study was to map the distribution of the preparation- and execution-related activity within the contralateral M1 ...

journal_title：Neuroscience letters

authors： Zang Y,Jia F,Weng X,Li E,Cui S,Wang Y,Hazeltine E,Ivry R

更新日期：2003-02-06 00:00:00

abstract：:Intracellular recordings were made from astrocytes of the hippocampal CA1 region in rat slice preparations. A single stimulus at the Schaffer collaterals with high intensities (>/=10 V), but not low intensities (<10 V), induced a slow depolarization similar to the evoked postsynaptic potentials observed in hippocampal...

journal_title：Neuroscience letters

authors： Hattori G,Tanaka E,Yokomizo Y,Shigemori M,Higashi H

更新日期：2003-06-05 00:00:00

abstract：:To determine the involvement of the medial prefrontal cortex (mPFC) in operant-type delayed alternation, microinjections of muscimol into the mPFC were used for temporal inactivation during behavioral tests in rats. The temporal mPFC inactivation showed effects related to both dorsal (decreased delay-dependent correct...

journal_title：Neuroscience letters

authors： Izaki Y,Maruki K,Hori K,Nomura M

更新日期：2001-11-27 00:00:00

abstract：:After spinal cord injury (SCI), a complex cascade of pathophysiological processes rapidly damages the nervous tissue. The initial damage spreads to the surrounding tissue by different mechanisms, including oxidative stress. We have recently reported that the induction of metallothionein (MT) protein is an endogenous r...

journal_title：Neuroscience letters

authors： Arellano-Ruiz S,Rios C,Salgado-Ceballos H,Méndez-Armenta M,Del Valle-Mondragón L,Nava-Ruiz C,Altagracia-Martínez M,Díaz-Ruiz A

更新日期：2012-04-11 00:00:00

abstract：:Amplitudes of contingent negative variation (CNV) as a slow cortical potential in migraine patients were recorded before and after migraine attacks. The level of CNV amplitudes, especially of the early component, showed a trend in rise of negativity 1 day before the attack, whereas amplitudes were normal for 2-3 days ...

journal_title：Neuroscience letters

authors： Kropp P,Gerber WD

更新日期：1998-11-27 00:00:00

abstract：:The effect of chronic salt loading on urocortin-like immunoreactivity (Ucn-IR) was investigated in the rat hypothalamo-neurohypophysial system. In control rats a few Ucn-IR neurons were observed scattered throughout the supraoptic nucleus (SON) and few in the paraventricular nucleus (PVN). A small number of Ucn-IR fib...

journal_title：Neuroscience letters

authors： Hara Y,Ueta Y,Isse T,Kabashima N,Shibuya I,Hattori Y,Yamashita H

更新日期：1997-05-16 00:00:00

abstract：:The localization of serotonin and non-serotonin-containing cell bodies in the interpeduncular nucleus of the rat that project to the hippocampal formation was studied using the technique of retrograde tracing of Granular Blue and immunohistochemistry on the same sections. The results indicate that the caudal magnocell...

journal_title：Neuroscience letters

authors： Groenewegen HJ,Steinbusch HW

更新日期：1984-09-28 00:00:00

abstract：:Using a combination of intracellular recording and morphological techniques, we describe the properties of a new cell type within layer II of the lateral entorhinal cortex. A thick and bifurcating apical dendrite and thinner basal dendrites extended from the pyramidal shaped cell body. The axon ramified within all sup...

journal_title：Neuroscience letters

authors： Empson RM,Gloveli T,Schmitz D,Heinemann U

更新日期：1995-07-07 00:00:00

abstract：:The modification of tuning properties in the cochlea has been studied by means of tuning curves from auditory nerve fibers in kittens of various ages. Comparison of tuning curves of three characteristic frequencies (CF) shows that the tuning of high CF units tends to approach adult values by the end of the second post...

journal_title：Neuroscience letters

authors： Romand R

更新日期：1983-03-14 00:00:00

abstract：:Abnormal neural activity generated at a site of nerve injury is thought to contribute to the development of dysaesthesia. Vanilloid receptor 1 (TRPV1), a transducer of noxious stimuli, may be involved in the initiation of this abnormal activity and could provide a useful therapeutic target. We investigated the effect ...

journal_title：Neuroscience letters

authors： Biggs JE,Yates JM,Loescher AR,Clayton NM,Robinson PP,Boissonade FM

更新日期：2008-09-26 00:00:00

abstract：:A previous study of brain activation in normal subjects during a phonological (Phonemes) task and a lexical semantic (Words) task using positron-emission tomography [3] is complemented by new data after a method for image realignment was applied [17]. The pattern of cerebral blood flow increases associated with Words ...

journal_title：Neuroscience letters

authors： Démonet JF,Price C,Wise R,Frackowiak RS

更新日期：1994-11-21 00:00:00

abstract：:Parkinson's disease (PD) is a progressive neurodegenerative disease. Majority of PD cases are sporadic, resulting from interaction of genetic and environmental factors. Accumulating evidence indicates that autophagy, which delivers alpha-synuclein to lysosomes for degradation, is involved in the PD pathogenesis. Some ...

journal_title：Neuroscience letters

authors： Wu G,Pang S,Feng X,Zhang A,Li J,Gu K,Huang J,Dong H,Yan B

更新日期：2011-08-01 00:00:00

abstract：:The objective of this study was to determine if yohimbine, a central norepinephrine enhancing drug, increases cortico-motoneuronal excitability in intact humans. Transcranial magnetic stimulation was used to assess excitability of the motor system reflected in the parameters motor threshold, recruitment curve, intraco...

journal_title：Neuroscience letters

authors： Plewnia C,Bartels M,Cohen L,Gerloff C

更新日期：2001-07-06 00:00:00

abstract：:The latency, duration of feeding and number of feeding periods recorded from rats after noradrenaline injection to the hippocampus show little change after unilateral 6-hydroxydopamine injections to the substantia nigra. It is suggested that 6-hydroxydopamine-induced weight losses result from non-specific effects of i...

journal_title：Neuroscience letters

authors： Oades RD

更新日期：1977-04-01 00:00:00

abstract：:Total RNA was purified from rat forebrain at different postnatal ages and analyzed by Northern blot using a specific neurotensin receptor RNA probe. The rat neurotensin receptor mRNA was present in high amount during the first 10 days of life. Thereafter, it rapidly decreased and was undetected after 20 days. [3H]neur...

journal_title：Neuroscience letters

authors： Hermans E,Jeanjean AP,Laduron PM,Octave JN,Maloteaux JM

更新日期：1993-07-09 00:00:00

abstract：:The distribution pattern of sialylated glycoproteins in the hippocampal formation of 9-week-old and 29-month-old rats was examined using Maackia amurensis lectin, specific for Sia alpha2-3Gal, and Sambucus sieboldiana agglutinin specific for Sia alpha2-6Gal(GalNAc), and a monoclonal antibody for a linear homopolymer o...

journal_title：Neuroscience letters

authors： Sato Y,Endo T

更新日期：1999-02-26 00:00:00

abstract：:Rats were treated with once-daily subcutaneous injections of atropine or normal saline for 10 days. Cryostat sections of fresh-frozen brain were subjected to quantitative muscarinic receptor ([3H]quinuclidinylbenzilate (QNB)) binding autoradiography, and quantitative in-situ hybridization autoradiography for beta-amyl...

journal_title：Neuroscience letters

authors： Beach TG,Walker DG,Cynader MS,Hughes LH

更新日期：1996-05-24 00:00:00

abstract：:In order to reveal neurodegeneration elicited by reactive oxygen intermediates (ROI), neuronally differentiated cells from mouse embryonal carcinoma P19 cell line were exposed to hydrogen peroxide (H2O2). Enhanced protein-phosphorylation on tyrosine residues was detectable within 5 min of exposure to H2O2, and gradual...

journal_title：Neuroscience letters

authors： Ishihara I,Minami Y,Nishizaki T,Matsuoka T,Yamamura H

更新日期：2000-01-28 00:00:00

abstract：:We have examined the morphology and distribution of nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-diaphorase) cells in the retina of the guinea pig. Two morphologically distinct classes of labelled cells were detected, one with larger, darkly labelled somata commonly located in the inner nuclear layer ...

journal_title：Neuroscience letters

authors： Cobcroft M,Vaccaro T,Mitrofanis J

更新日期：1989-08-14 00:00:00

abstract：:The synucleins are a family of small proteins expressed in nervous tissue, which have been implicated in neurodegeneration. Using single strand conformation polymorphism analysis we screened for polymorphisms and mutations in the gene encoding human persyn, a recently discovered member of the synuclein family, in cont...

journal_title：Neuroscience letters

authors： Flowers JM,Leigh PN,Davies AM,Ninkina NN,Buchman VL,Vaughan J,Wood NW,Powell JF

更新日期：1999-10-15 00:00:00

abstract：:Crayfish muscle fibres were voltage-clamped at E = -80 mV membrane potential and superfused for about 10 min with Li+ saline (Na+ replaced by Li+) which contained picrotoxin to block inhibitory post-synaptic currents. Addition of veratridine (100 mumol/l) caused intense fluctuations in the voltage clamp current within...

journal_title：Neuroscience letters

authors： Finger W,Martin C

更新日期：1987-12-16 00:00:00

abstract：:Restoration of cellular microenvironment is important in the treatment of neurodegenerative diseases for optimal functioning and survival of neurons. Oxidative stress has been proposed as one of the major pathogenic drivers in Parkinson's disease. Parkinson's model was developed by chronic administration of a pesticid...

journal_title：Neuroscience letters

authors： Bandookwala M,Sahu AK,Thakkar D,Sharma M,Khairnar A,Sengupta P

更新日期：2019-10-15 00:00:00

abstract：:The enzyme Fatty Acid Amide Hydrolase (FAAH) is a key regulator of the endogenous levels of a family of biologically active lipid mediators, the fatty acid amides. These include anandamide, oleoyl ethanolamide and palmitoyl ethanolamide, and their effects are mediated by a variety of downstream targets including canna...

journal_title：Neuroscience letters

authors： Webb M,Luo L,Ma JY,Tham CS

更新日期：2008-07-04 00:00:00