Abstract:
:Membrane currents of cultured human monocytes and rat microglia were recorded with the whole-cell patch clamp technique. Freshly isolated monocytes or resting (proliferating) microglia express only inwardly rectifying K+ channels. However, incubation in teflon bags leads to the expression of additional, outwardly rectifying K+ channels. The outward K+ conductance of microglial cells was inhibited by intracellular Cs+ and extracellular 4-aminopyridine or tetraethylammonium. Functional similarities with the microglial outwardly rectifying K+ channel were found in the Kn-channel of lymphocytes which has recently been cloned (RGK5). The polymerase chain reaction (PCR) was used to demonstrate the presence of RGK5-like mRNA in microglia.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Nörenberg W,Appel K,Bauer J,Gebicke-Haerter PJ,Illes Pdoi
10.1016/0304-3940(93)9001-0subject
Has Abstractpub_date
1993-09-17 00:00:00pages
69-72issue
1eissn
0304-3940issn
1872-7972pii
0304-3940(93)9001-0journal_volume
160pub_type
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