Abstract:
:The neuroprotective activity of riluzole has been studied on N-methyl-D-aspartate (NMDA)- or veratridine-induced toxicity in immature rat hippocampal slices. Neurodegeneration was assessed by the measurement of LDH release and histology. Veratridine-induced LDH release can be inhibited by 100 microM riluzole (-90% and by tetrodotoxin (1 microM). Riluzole markedly reduced (-59%) the NMDA-induced LDH release and this protective effect was confirmed by histology. Riluzole inhibited the NMDA-induced LDH release in the presence of tetrodotoxin. Moreover, a pretreatment with pertussis toxin (1 microgram/ml) abolished the effect of riluzole against NMDA-induced neurotoxicity. These results support the view that the neuroprotective properties of riluzole could be exerted via two distinct mechanisms of action.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Malgouris C,Daniel M,Doble Adoi
10.1016/0304-3940(94)90053-1subject
Has Abstractpub_date
1994-08-15 00:00:00pages
95-9issue
1-2eissn
0304-3940issn
1872-7972pii
0304-3940(94)90053-1journal_volume
177pub_type
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