Abstract:
:The pineal product melatonin that acts on specific melatonin receptors has been implicated in pathobiological mechanisms of neuropsychiatric disorders including Alzheimer's disease. We used mice lacking melatonin MT(2) receptors (MT(2) knockouts) to investigate the role of these receptors in synaptic plasticity and learning-dependent behavior. In field CA1 of hippocampal slices from wild-type mice, theta burst stimulation induced robust and stable long-term potentiation that was smaller and decremental in slices from MT(2) knockouts. Tested in an elevated plus-maze on two consecutive days, wild-type mice showed shorter transfer latencies to enter a closed arm on the second day; this experience-dependent behavior did not occur in MT(2) knockouts. These results suggest that MT(2) receptors participate in hippocampal synaptic plasticity and in memory processes.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Larson J,Jessen RE,Uz T,Arslan AD,Kurtuncu M,Imbesi M,Manev Hdoi
10.1016/j.neulet.2005.09.040keywords:
subject
Has Abstractpub_date
2006-01-23 00:00:00pages
23-6issue
1eissn
0304-3940issn
1872-7972pii
S0304-3940(05)01098-0journal_volume
393pub_type
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