Abstract:
:A new method for on-line analysis of in vivo differential normal pulse voltammograms is reported. They are fitted by least squares to an expression describing the contribution of different electroactive species and the baseline. Its validity for resolving ascorbate (AA), dopamine (DA) and DOPAC signals is evidenced by both in vitro testing and the changes recorded in the striatum of anesthetized rats following drug treatments having well-known effects on DA release and metabolism. Thus, pargyline and amphetamine treatments respectively increased and decreased DA and DOPAC, whereas they both were increased by haloperidol. AA levels followed those of DA except when haloperidol was given.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Gonzalez-Mora JL,Sanchez-Bruno JA,Mas Mdoi
10.1016/0304-3940(88)90183-8subject
Has Abstractpub_date
1988-03-21 00:00:00pages
61-6issue
1eissn
0304-3940issn
1872-7972pii
0304-3940(88)90183-8journal_volume
86pub_type
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