Concurrent on-line analysis of striatal ascorbate, dopamine and dihydroxyphenylacetic acid concentrations by in vivo voltammetry.

Abstract:

:A new method for on-line analysis of in vivo differential normal pulse voltammograms is reported. They are fitted by least squares to an expression describing the contribution of different electroactive species and the baseline. Its validity for resolving ascorbate (AA), dopamine (DA) and DOPAC signals is evidenced by both in vitro testing and the changes recorded in the striatum of anesthetized rats following drug treatments having well-known effects on DA release and metabolism. Thus, pargyline and amphetamine treatments respectively increased and decreased DA and DOPAC, whereas they both were increased by haloperidol. AA levels followed those of DA except when haloperidol was given.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Gonzalez-Mora JL,Sanchez-Bruno JA,Mas M

doi

10.1016/0304-3940(88)90183-8

subject

Has Abstract

pub_date

1988-03-21 00:00:00

pages

61-6

issue

1

eissn

0304-3940

issn

1872-7972

pii

0304-3940(88)90183-8

journal_volume

86

pub_type

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