Abstract:
:Cognitive impairment in Parkinson's disease is accompanied by a marked decrease of cerebrocortical nicotinic receptors. To study the putative site of impaired receptor synthesis, frontal cortices of Parkinson patients with cognitive dysfunction have been screened for the expression of the nicotinic receptor alpha 4 subunit gene. Quantitative assessment of alpha 4 mRNA-expressing neurons did not show significant differences between patients and controls. Therefore, decreased nicotinic receptor sites cannot be attributed to alterations at the transcriptional level of the alpha 4 gene. Alternative causes have to be searched for at the translational and/or postranslational level.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Schröder H,de Vos RA,Jansen EN,Birtsch C,Wevers A,Lobron C,Nowacki S,Schröder R,Maelicke Adoi
10.1016/0304-3940(95)11367-6subject
Has Abstractpub_date
1995-03-10 00:00:00pages
173-6issue
3eissn
0304-3940issn
1872-7972pii
0304394095113676journal_volume
187pub_type
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