Widespread up-regulation of N-methyl-D-aspartate receptors after focal photothrombotic lesion in rat brain.

abstract：:We examined whether bisphenol A (BPA) and 4-nonylphenol (NP) influenced staurosporine-induced neuronal cell death in primary cultured rat hippocampal and cortical neurons. In hippocampal neurons, 17beta-estradiol (E2) (1 nM and 10 microM) and BPA (10 microM) significantly inhibited the staurosporine-induced release of...

journal_title：Neuroscience letters

authors： Negishi T,Ishii Y,Kyuwa S,Kuroda Y,Yoshikawa Y

更新日期：2003-12-19 00:00:00

abstract：:Amyloid beta (A beta) is a normal proteolytic fragment of a large precursor protein (beta PP) which undergoes altered conformation, leading to fibril formation. Two main beta PP processing pathways have been described, and we are now reporting the characterization of a third beta PP pathway. A membrane-associated 16 k...

journal_title：Neuroscience letters

authors： Ghiso J,Gardella JE,Liem L,Gorevic PD,Frangione B

更新日期：1994-04-25 00:00:00

abstract：:GABAergic modulation of enkephalin, substance P and glutamic acid decarboxylase (GAD67) gene expression and the alterations induced by dopamine receptor blockade were studied in the rat striatum. Following subchronic treatment with the GABA-A agonist muscimol, the GABA-B agonist baclofen or the GABA transaminase inhib...

journal_title：Neuroscience letters

authors： Jolkkonen J,Jenner P,Marsden CD

更新日期：1994-10-24 00:00:00

abstract：:We have previously shown that glycine binding sites on presynaptic NMDA receptors (NMDA-Rs) can tonically regulate glutamate release in the rat visual cortex. In the present study, we investigated the subunit composition of these presynaptic NMDA-Rs. We recorded miniature a-amino-3-hydroxy-5-methyl-4-isoxazolepropioni...

journal_title：Neuroscience letters

authors： Li YH,Han TZ,Meng K

更新日期：2008-02-27 00:00:00

abstract：:Na+, K+-ATPase is one of major membrane proteins that has two subunits, alpha and beta. The alpha subunit has the ATPase activity and the ouabain binding site. Among four isoforms of the alpha subunit, expression of alpha1, alpha2, and alpha3, but not alpha4, is observed in matured rat brain. Ouabain is one of cardiac...

journal_title：Neuroscience letters

authors： Taguchi K,Kumanogoh H,Nakamura S,Maekawa S

更新日期：2007-02-08 00:00:00

abstract：AIMS:To test the hypothesis that uridine 5'-triphosphate (UTP) had a protective effect on cerebral ischemia reperfusion (IR) injury in rats. METHODS:Ischemia was induced by intraluminal suture of middle cerebral artery occlusion (MCAO). UTP solution was delivered through an indwelling tail venous catheter via microinf...

journal_title：Neuroscience letters

authors： Tian ML,Zou Z,Yuan HB,Wang CC,Zhu QF,Xu HT,Gao X,Shi XY

更新日期：2009-11-06 00:00:00

abstract：:The cellular localisation of benzodiazepine receptors was studied. Kainic acid induced neuronal lesions (2 x 0.25-2 x 2 micrograms; 2-26 days in rat cerebellum decreased specific binding of [3H]flunitrazepam down to 35% of controls. Specific binding of [3H]flunitrazepam was also decreased (to 80% of controls) in the c...

journal_title：Neuroscience letters

authors： Braestrup C,Nielsen M,Biggio G,Squires RF

更新日期：1979-08-01 00:00:00

abstract：:Approximately 8.5% of the unmyelinated and 2.5% of the myelinated primary afferent axons in lumbar dorsal roots of normal rats are immunostained for glutamate. Thus unmyelinated fibers are the predominantly immunostained population under the conditions of our experiments. The mean size of the unmyelinated fibers is gr...

journal_title：Neuroscience letters

authors： Westlund KN,McNeill DL,Coggeshall RE

更新日期：1989-01-02 00:00:00

abstract：:Whole-cell patch-clamp recordings were made from kidney-related neurons in the intermediolateral cell column (IML) in horizontal slices of thoracolumbar spinal cord from adult rats. Kidney-related neurons were identified in vitro subsequent to inoculation of the kidney with a fluorescent, retrograde, transynaptic pseu...

journal_title：Neuroscience letters

authors： Derbenev AV,Duale H,Rabchevsky AG,Smith BN

更新日期：2010-05-03 00:00:00

abstract：:Rats were injected (i.p.) once daily with either 1 mg/kg CGP 56999A, a gamma-aminobutyric acid(B) (GABA(B)) receptor antagonist, or an equivalent volume of saline beginning 7 days prior to, and continuing for 7 days following, a unilateral 6-hydroxydopamine lesion of the nigrostriatal dopamine (DA) pathway. At the end...

journal_title：Neuroscience letters

authors： Enna SJ,Reisman SA,Stanford JA

更新日期：2006-10-02 00:00:00

abstract：:Previous tracer studies have revealed the sacculus to be connected to the vestibular and cochlear nuclei in the guinea pig. Due to its own innervation pattern, an anterior and posterior part of the sacculus can be distinguished. The present study investigated whether the two parts differ concerning their fiber contrib...

journal_title：Neuroscience letters

authors： Gstoettner W,Burian M,Zundritsch R,Mayr R

更新日期：1991-01-28 00:00:00

abstract：:Treatment with acamprosate, a compound used for relapse prevention treatment of alcoholism, was recently shown to be associated with increased plasma concentration of beta-endorphin in rats selectively bred for high alcohol preference. The aim of our study was to prove this result in a comparative clinical study with ...

journal_title：Neuroscience letters

authors： Kiefer F,Jahn H,Otte C,Nakovics H,Wiedemann K

更新日期：2006-08-14 00:00:00

abstract：:This study examines the ultrastructural relationships established by the nigrostriatal dopaminergic and the corticostriatal afferent fibers with neuropeptide Y (NPY)-containing neurons in the rat striatum. By means of dual immunolabeling procedures using peroxidase conjugated F(ab) fragments and 125I-labeled protein A...

journal_title：Neuroscience letters

authors： Vuillet J,Kerkerian L,Kachidian P,Bosler O,Nieoullon A

更新日期：1989-05-22 00:00:00

abstract：:The effects of intracerebroventricular (i.c.v.) administration of dopamine receptor antagonists on the calcium-dependent brain function that reduces blood pressure were investigated. The systolic blood pressure of spontaneously hypertensive rats (SHR; male, 13 weeks of age) was reduced following i.c.v. administration ...

journal_title：Neuroscience letters

authors： Sutoo D,Akiyama K

更新日期：1999-07-16 00:00:00

abstract：:The possible involvement of 2-amino-4-phosphonobutyrate (APB) recognition sites in mechanisms enabling the maintenance of long-term potentiation (LTP) was investigated in rat hippocampal slices. The action of D(-)- and L(+)-isomers of APB was tested on orthodromic EPSP and spike responses recorded extracellularly from...

journal_title：Neuroscience letters

authors： Reymann KG,Matthies H

更新日期：1989-03-27 00:00:00

abstract：:To explore the possible cellular source and mechanism of apolipoprotein E (apoE) expression in mechanical injured neuronal cultures. Primary cultured mouse cortical neurons were subjected into mechanical injury by needle scratching. The conditioned medium of wild type (WT) primary mouse astrocytes was collected and ad...

journal_title：Neuroscience letters

authors： Yin C,Zhou S,Jiang L,Sun X

更新日期：2012-04-25 00:00:00

abstract：:We evaluated the modulation of baroreceptor reflex (BRR) response by locus coeruleus (LC) in adult, male Sprague-Dawley rats anesthetized with urethane (1.5 g/kg, i.p.). Under an electrical stimulation condition that did not appreciably alter the basal systemic arterial pressure and heart rate, the LC significantly su...

journal_title：Neuroscience letters

authors： Chan JY,Jang SF,Chan SH

更新日期：1992-09-14 00:00:00

abstract：:We studied the altered molecular species of lipids in brain and liver tissues, and fibroblasts from patients with Zellweger syndrome (ZS). ZS cerebellum samples contained a higher amount of sphingomyelin with shorter chain fatty acids compared to that in normal controls. The amount of phosphatidylethanolamine (PE) was...

journal_title：Neuroscience letters

authors： Miyazaki C,Saitoh M,Itoh M,Yamashita S,Miyagishi M,Takashima S,Moser AB,Iwamori M,Mizuguchi M

更新日期：2013-09-27 00:00:00

abstract：OBJECTIVE:Exploring the impact of glucocerebrosidase gene (GBA) polymorphisms and mutations on the pathogenesis of Parkinson's disease dementia (PDD) plays an important role in the diagnosis and treatment of this disease. This meta-analysis aimed to investigate the effects of GBA polymorphisms and mutations on the risk...

journal_title：Neuroscience letters

authors： Zhang Y,Chen J,Xu C,Feng J,Li J

更新日期：2020-01-01 00:00:00

abstract：:Ovariectomy in the rat abolishes alpha-bungarotoxin (alpha-BTX) binding within the suprachiasmatic nucleus (SCN), a putative circadian pacemaker, and markedly reduces cholinergic activation of SCN cells. Circadian rhythms of running wheel activity were monitored continuously in intact male and female and chronically o...

journal_title：Neuroscience letters

authors： Mistlberger RE,Rusak B

更新日期：1986-12-23 00:00:00

abstract：:We examined the rubrospinal projection to forelimb motoneurons (Mns) in cats, in comparison with the corticospinal projection. Under pentobarbital anesthesia, intracellular recordings were made from forelimb Mns following stimulation of the red nucleus (RN) and the cerebral peduncle (CP). Single pulse stimulation of t...

journal_title：Neuroscience letters

authors： Fujito Y,Imai T,Aoki M

更新日期：1991-06-10 00:00:00

abstract：:Parkin gene mutations are by far the most common mutations in both familial Parkinson's disease (PD) and sporadic PD. Approximately, 50% of parkin mutations is exon dosage mutations (i.e., deletions and duplications of entire exons). Here, we first established a MLPA assay for quick detection of parkin exon rearrangem...

journal_title：Neuroscience letters

authors： Guo JF,Dong XL,Xu Q,Li N,Yan XX,Xia K,Tang BS

更新日期：2015-09-14 00:00:00

abstract：:Doxorubicin, a fluorescent retrograde neurotoxin, killed neurons in the ventral tegmentum and thalamus that were afferent to the injection site in the caudate-putamen. The neurotoxic effects in the ventral tegmentum and thalamus were prevented by a large coronal knife cut caudal to the injection site in the striatum, ...

journal_title：Neuroscience letters

authors： van der Kooy D,Zito KA,Roberts DC

更新日期：1985-01-21 00:00:00

abstract：:The nucleus raphe magnus belongs to the thermoafferent system. Following iontophoretic choleratoxin b injections in its rostral part, a substantial to large number of anterogradely labeled varicose fibres were observed in the medial and lateral preoptic areas, the bed nucleus, the substantia innominata, the ventral pa...

journal_title：Neuroscience letters

authors： Hermann DM,Luppi PH,Peyron C,Hinckel P,Jouvet M

更新日期：1996-10-04 00:00:00

abstract：:Several clinical and epidemiological studies suggest that Alzheimer's disease (AD) and vascular dementia share common risk factors. Oxidative stress is one of these well recognized factors. It can result from an excess of free-radical activity and impaired antioxidant defenses. Paraoxonase (PON1), a component of high ...

journal_title：Neuroscience letters

authors： Helbecque N,Cottel D,Codron V,Berr C,Amouyel P

更新日期：2004-03-18 00:00:00

abstract：:Occurring at rates up to 6-7 syllables per second, speech perception and understanding involves rapid identification of speech sounds and pre-activation of morphemes and words. Using event-related potentials (ERPs) and functional magnetic resonance imaging (fMRI), we investigated the time-course and neural sources of ...

journal_title：Neuroscience letters

authors： Roll M,Söderström P,Frid J,Mannfolk P,Horne M

更新日期：2017-09-29 00:00:00

abstract：:Male and female eels were hypophysectomized by a buccal approach and examined either 2 and 7 weeks (males) or 4 and 5 months (females) later. Intact and sham-operated eels served as controls. Fish were killed by decapitation, and the brains fixed in sublimated Bouin-Hollande solution and embedded in paraffin wax. Fron...

journal_title：Neuroscience letters

authors： Olivereau M,Olivereau J

更新日期：1988-09-12 00:00:00

abstract：:We compared cerebrospinal fluid (CSF) and serum levels, and the CSF/serum ratio of alpha-tocopherol (vitamin E), measured by HPLC, in 36 patients with multiple sclerosis (MS) and 32 matched controls. The mean CSF vitamin E levels and the CSF/serum vitamin E ratio did not differ significantly between the two study grou...

journal_title：Neuroscience letters

authors： Jiménez-Jiménez FJ,de Bustos F,Molina JA,de Andrés C,Gasalla T,Ortí-Pareja M,Zurdo M,Porta J,Castellano-Millán F,Arenas J,Enríquez de Salamanca R

更新日期：1998-06-12 00:00:00

abstract：:Superoxide dismutase 1 (SOD1) aggregates are a histological and biochemical correlate of disease progression in neural tissues from mutant SOD1-linked forms of familial amyotrophic lateral sclerosis (FALS). In the present study, we assayed the monomeric and high molecular weight mutant SOD1 content of nervous, muscle ...

journal_title：Neuroscience letters

authors： Turner BJ,Lopes EC,Cheema SS

更新日期：2003-10-23 00:00:00

abstract：:N-omega-[18F]fluoroethylketanserin ([18F]FEK), an 18F-labeled analogue of the serotonin S2 antagonist ketanserin, was evaluated for use with positron emission tomography (PET). PET imaging of a baboon brain following injection of [18F]FEK indicated that the fluorinated ligand rapidly localized in vivo within S2 recept...

journal_title：Neuroscience letters

authors： Moerlein SM,Perlmutter JS

更新日期：1991-02-11 00:00:00