Effects of glucocerebrosidase gene polymorphisms and mutations on the risk of Parkinson's disease dementia: A meta-analysis.

abstract：:We aimed to compare immunoreactivity patterns of four different anti-α-syn antibodies in surgical specimens of the gastrointestinal tract of Parkinson disease and control cases. Surgical specimens from stomach, small and large bowel of 6 PD cases and 12 controls were studied. Primary antibodies: anti-α-syn clone KM51,...

journal_title：Neuroscience letters

authors： Aldecoa I,Navarro-Otano J,Stefanova N,Sprenger FS,Seppi K,Poewe W,Cuatrecasas M,Valldeoriola F,Gelpi E,Tolosa E

更新日期：2015-08-18 00:00:00

abstract：:Five monoclonal antibodies specific for rat monocytes/macrophages were used to characterize macrophages/microglia bulk isolated from neonatal and adult rat brain. The majority of brain macrophages was positive for all antibodies tested with minor differences between cultures derived from developing and mature central ...

journal_title：Neuroscience letters

authors： Graeber MB,Banati RB,Streit WJ,Kreutzberg GW

更新日期：1989-09-11 00:00:00

abstract：:The pattern and distribution of the cortical projections from intermediate parts of the cholinergic basal magnocellular nucleus were studied by anterogradely transported Phaseolus vulgaris-leucoagglutinin. This immunocytochemical tracing technique reveals the detailed morphology and distribution of efferents from this...

journal_title：Neuroscience letters

authors： Luiten PG,Spencer DG Jr,Traber J,Gaykema RP

更新日期：1985-06-12 00:00:00

abstract：:The mitochondrial transcription factor A (TFAM) has been recently shown to decrease reactive oxygen species (ROS) generation. It is also known that mitochondrial DNA (mtDNA) haplogroups might confer different coupling properties, resulting in different ROS levels. We hypothesized that potentially functional TFAM varia...

journal_title：Neuroscience letters

authors： Gaweda-Walerych K,Safranow K,Maruszak A,Bialecka M,Klodowska-Duda G,Czyzewski K,Slawek J,Rudzinska M,Styczynska M,Opala G,Drozdzik M,Kurzawski M,Szczudlik A,Canter JA,Barcikowska M,Zekanowski C

更新日期：2010-01-18 00:00:00

abstract：:The reverse transcriptase polymerase chain reaction (RT-PCR) technique was used to examine the changes of the expression of 5-hydroxytryptamine (5-HT) receptors in the rat lumbar dorsal root ganglion (DRG) following subcutaneous bee venom (BV) injection into the plantar surface of the unilateral hindpaw. In the DRG ip...

journal_title：Neuroscience letters

authors： Liu XY,Wu SX,Wang YY,Wang W,Zhou L,Li YQ

更新日期：2005-02-25 00:00:00

abstract：:To determine whether central alpha 1 and alpha 2-adrenergic mechanisms are involved in urinary sodium and potassium excretion and urine volume induced by angiotensin II (ANGII), these renal parameters were measured in volume-expanded Holtzman rats with cannulas implanted into lateral ventricle (LV) and lateral hypotha...

journal_title：Neuroscience letters

authors： Saad WA,Camargo LA,Renzi A,Menani JV,Saad WA

更新日期：1995-07-21 00:00:00

abstract：:Glutamic acid (Glu) participates in pain modulation of the central nervous system. The CA3 region of the hippocampal formation has been suggested to be involved in nociceptive perception. However, it is unknown whether Glu could modulate the electrical activities of pain-related neurons in the hippocampal CA3 region. ...

journal_title：Neuroscience letters

authors： Ma X,Shi TF,Zhang M,Lu XY,Yang CX,Zhu D,Shi DX,Yang Y,Wang CL,Zhang S,Xu MY

更新日期：2012-03-28 00:00:00

abstract：:Intracellular recordings from luminosity-type horizontal cells of the turtle retina were used to analyze the effects of steady and flickering background illumination on the size of their receptive fields. Both types of background illumination reduce the size of the receptive field to about the same extent. The reducti...

journal_title：Neuroscience letters

authors： Weiler R,Akopian A

更新日期：1992-06-08 00:00:00

abstract：:There is considerable evidence linking both genotype and coagulopathy to vascular complications of traumatic brain injury (TBI) and other cerebral insults. The authors explored a possible connection between the apolipoprotein E (Apo E) genotype, coagulopathy and intravascular microthombosis (IMT) in TBI. The predicted...

journal_title：Neuroscience letters

authors： Stein SC,Graham DI,Chen XH,Dunn L,Smith DH

更新日期：2005-10-14 00:00:00

abstract：:Using inside-out configuration of patch clamp techniques, actin cytoskeleton modulation of large conductance calcium-activated potassium (BK(Ca)) channels was studied in hippocampal CA1 pyramidal neurons from adult rat. Disruption of actin filament after brief treatment with cytochalasin D (CD) markedly decreased acti...

journal_title：Neuroscience letters

authors： Huang H,Rao Y,Sun P,Gong LW

更新日期：2002-10-31 00:00:00

abstract：:Strychnine blocked the vagal-induced cardiac inhibition in both perfused frog heart and dog's heart in situ. This effect was antagonized by eserine. The present results are consistent with our previous findings that strychnine blocks the cholinergic inhibitory mechanisms both in the central nervous system as well as i...

journal_title：Neuroscience letters

authors： Bhargava VK,Bhargava P,Tripathi KD

更新日期：1977-02-01 00:00:00

abstract：:Our aim was to investigate the neuromodulatory role of diadenosine tetraphosphate (Ap(4)A). Ap(4)A-binding sites were detected in striatum and hippocampus membranes using [(35)S]-ADP beta S as radioligand and Ap(4)A and epsilon-(Ap(4)A), di-ethenoadenosine tetraphosphate, as displacers. Effects of epsilon-(Ap(4)A) on ...

journal_title：Neuroscience letters

authors： Oaknin S,Rodríguez-Ferrer CR,Aguilar JS,Ramos A,Rotllán P

更新日期：2001-08-31 00:00:00

abstract：:Near-infrared spectroscopy (NIRS) is a non-invasive optical technique which has been successfully used to register substantial cerebral ischemia. There are indications that NIRS is sensible enough to detect also small metabolic changes during the performance of cognitive tasks. In the present study, two-channel NIRS o...

journal_title：Neuroscience letters

authors： Fallgatter AJ,Strik WK

更新日期：1997-02-21 00:00:00

abstract：:Basal forebrain (BF) lesions induced by ibotenic acid produced increases in the Bmax and Kd values of [3H]QNB binding sites in the frontal cortex, parietal cortex, and hippocampus. Twenty-eight-day successive administration of propentofylline (10 and 25 mg/kg, p.o.) significantly reduced the Kd values of [3H]QNB bindi...

journal_title：Neuroscience letters

authors： Fuji K,Hiramatsu M,Hayashi S,Kameyama T,Nabeshima T

更新日期：1993-02-05 00:00:00

abstract：:The objective of the present study was to characterize the trkB receptor immunoreactive (-ir) cells in the intermediolateral cell column (IML) of the upper thoracic spinal cord. Small trkB-ir cells (area=56.1+/-4.4 microm(2)) observed in the IML showed characteristics of oligodendrocytes and were frequently observed i...

journal_title：Neuroscience letters

authors： McCartney AM,Abejuela VL,Isaacson LG

更新日期：2008-08-01 00:00:00

abstract：:By the use of light microscopic immunohistochemistry it was shown that a significant population of small primary sensory afferents of guinea pig contains immunoreactivities to antisera directed against prodynorphin-opioid peptides, whereas immunoreactivities to antisera directed against opioid peptides exclusively con...

journal_title：Neuroscience letters

authors： Weihe E,Hartschuh W,Weber E

更新日期：1985-08-05 00:00:00

abstract：:Foxp2(R552H) knock-in (KI) mice carrying a mutation related to human speech-language disorder exhibit impaired ultrasonic vocalization and poor Purkinje cell development. Foxp2 is a forkhead domain-containing transcriptional repressor that associates with its co-repressor CtBP; Foxp2(R552H) displays reduced DNA bindin...

journal_title：Neuroscience letters

authors： Fujita E,Tanabe Y,Momoi MY,Momoi T

更新日期：2012-01-11 00:00:00

abstract：:[125I]Iodomelatonin ([125I]MEL) binding in chicken spinal cords was characterized. The specific binding of [125I]MEL to the membrane preparation of spinal cord was rapid, stable, saturable, reversible, specific and of high affinity. Scatchard analysis of the specific binding data indicated an equilibrium dissociation ...

journal_title：Neuroscience letters

authors： Wan Q,Pang SF

更新日期：1993-11-26 00:00:00

abstract：:The aim of the study was to investigate the characteristics of the oscillatory dynamics of brain activity during the perception of negative, positive, and neutral sentences in healthy individuals with differing severity of depressive symptoms at the preclinical stage. The study involved 34 healthy people (22 women). T...

journal_title：Neuroscience letters

authors： Bocharov AV,Savostyanov AN,Tamozhnikov SS,Merkulova EA,Saprigyn AE,Proshina EA,Knyazev GG

更新日期：2020-05-29 00:00:00

abstract：:Baclofen reduced the frequency and aborted the bursts of spontaneous paroxysmal discharges in rat neocortical slices maintained in magnesium-free medium. This action was prevented by pretreatment with barium or caesium, which each increased the ictaform burst frequency, amplitude and duration. 4-Amino-pyridine also in...

journal_title：Neuroscience letters

authors： Ong J,Kerr DI,Johnston GA

更新日期：1990-05-04 00:00:00

abstract：:The modification of tuning properties in the cochlea has been studied by means of tuning curves from auditory nerve fibers in kittens of various ages. Comparison of tuning curves of three characteristic frequencies (CF) shows that the tuning of high CF units tends to approach adult values by the end of the second post...

journal_title：Neuroscience letters

authors： Romand R

更新日期：1983-03-14 00:00:00

abstract：:Transcranial direct current stimulation (tDCS) is a non-invasive technique that moderates cognitive and motor function. The effects of tDCS on cognitive and motor tasks vary among individuals. However, the source of the inter-individual variability remains unknown. The purpose of the present study was to examine wheth...

journal_title：Neuroscience letters

authors： Kasahara K,Tanaka S,Hanakawa T,Senoo A,Honda M

更新日期：2013-06-17 00:00:00

abstract：:Neuronal voltage-dependent P/Q Ca2+ channels are genetically abnormal in many cases of familial hemiplegic migraine and possibly associated with the more common forms of migraine with and without aura. Besides the brain, these channels are found in motor nerve endings where they control stimulation-induced acetylcholi...

journal_title：Neuroscience letters

authors： Ambrosini A,de Noordhout AM,Alagona G,Dalpozzo F,Schoenen J

更新日期：1999-12-10 00:00:00

abstract：:Gap junctions between neurons contribute to synchronous neuronal firing and may play a role in the pathophysiology of epilepsy. We examined the expression of a number of gap junction subunits, including the neuronal gap junction forming protein connexin36 (Cx36), in the hippocampus at various time points following an ...

journal_title：Neuroscience letters

authors： McCracken CB,Roberts DC

更新日期：2006-09-11 00:00:00

abstract：:We have previously used antisense oligodeoxynucleotides (ODN) to the cloned delta opioid receptor (DOR) to inhibit the antinociceptive response to spinally administered delta opioid receptor selective agonists in mice. Here we have examined the effect of DOR antisense ODN treatment on the level of DOR expressed in NG ...

journal_title：Neuroscience letters

authors： Lai J,Riedl M,Stone LS,Arvidsson U,Bilsky EJ,Wilcox GL,Elde R,Porreca F

更新日期：1996-08-09 00:00:00

abstract：:We identified a 45-kDa protein by 2D electrophoresis that was enhanced following pentylenetetrazol (PTZ)-mediated seizures. Mass-spectrography of this protein revealed the beta subunit of Ca2+/calmodulin-dependent protein kinase II (CaMKIIbeta), although no evidence for increase in bulk CaMKIIbeta transcripts was obta...

journal_title：Neuroscience letters

authors： Matsu-ura T,Nakadai T,Oda Y,Nagasu T,Mikoshiba K,Tamura TA

更新日期：2002-04-12 00:00:00

abstract：:gamma-Aminobutyric acid (GABA)-mediated neurotransmission from the granule cells to CA3 is transiently expressed during the first 3 weeks of age in the rat. In the adult, seizures provoke this inhibitory signaling to reappear. To gain insight into the origin of GABA in these cells, we explored the expression of both i...

journal_title：Neuroscience letters

authors： Maqueda J,Ramírez M,Lamas M,Gutiérrez R

更新日期：2003-12-15 00:00:00

abstract：:The width of the attentional focus during the selection of one of two concurrent normal human participants was investigated using event-related potentials. Two stories were presented from virtual locations located 15° to the left and right azimuth by convolving the speech message by the appropriate head-related transf...

journal_title：Neuroscience letters

authors： Lambrecht J,Spring DK,Münte TF

更新日期：2011-02-01 00:00:00

abstract：:The effect of bifemelane hydrochloride (BFH) on the induction of heat shock protein (HSP) 70 and heat shock cognate protein (HSC) 70 mRNAs after transient global ischemia in gerbil brain was investigated by in situ hybridization using cloned cDNA probes selective for each mRNA species. Following 3.5 min of ischemia, H...

journal_title：Neuroscience letters

authors： Aoki M,Abe K,Liu XH,Lee TH,Kato H,Kogure K

更新日期：1993-05-14 00:00:00

abstract：:Chronic morphine administration induces neural plasticity followed by withdraw. And clinic observation indicates that obvious cognitive deficits are found during withdrawal. However, current neural substrates that regulate dysfunction in withdrawal are unknown. In our studies, chronic morphine administration was used ...

journal_title：Neuroscience letters

authors： Niu H,Zhang G,Li H,Zhang Q,Li T,Ding S,Wang L,Zhang Z,Qiao Y,Hu M

更新日期：2017-02-15 00:00:00